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KN-62

KN-62 is a derivative of isoquinolinesulfonamide, it is a selective, specific and cell permeable inhibitor of Ca2+/calmodulin-dependent kinase type II (CaMK II) with IC50 of 900nM, charactered by hydrophobicity. KN-62 also potently inhibits the purinergic receptor P2X7.

Standards, Inhibitory mechanism on CaMK II & Overview

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Overview

Inhibitory mechanism on CaMK II

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Map overview Semantic statistics

KN-62

Nodes14
Edges13
Triples9
Avg. degree1.86
Density0.142857
Components1

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KN-62

Top relations

related to Inhibitory mechanism on CaMK II · 8
KN-62 → Besides, CaM, CaMK II, CaMK II's, IC50, Kinetic, P2RX7, Since KN-62
is a · 1
KN-62 → derivative of isoquinolinesulfonamide

Important terminology Word statistics

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Important terminology

ii camk calmodulin ic50 references also purinergic receptor standard state inhibitory hydrophobicity p2x7 binding site derivative isoquinolinesulfonamide selective specific cell

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
KN-62is aderivative of isoquinolinesulfonamide0.90text
KN-62related to Inhibitory mechanism on CaMK IICaM0.60section
KN-62related to Inhibitory mechanism on CaMK IICaMK II0.60section
KN-62related to Inhibitory mechanism on CaMK IICaMK II's0.60section
KN-62related to Inhibitory mechanism on CaMK IIKinetic0.60section
KN-62related to Inhibitory mechanism on CaMK IISince KN-620.60section
KN-62related to Inhibitory mechanism on CaMK IIBesides0.60section
KN-62related to Inhibitory mechanism on CaMK IIP2RX70.60section
KN-62related to Inhibitory mechanism on CaMK IIIC500.60section

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