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Humanin

Humanin is a micropeptide encoded in the mitochondrial genome by the 16S ribosomal RNA gene, MT-RNR2. Its structure contains a three-turn α-helix, and no symmetry.

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Aliases
RNR2, mitochondrially encoded 16S RNA, MTRNR2
Available structures
Available structuresPDBHuman UniProt search: PDBe RCSB List of PDB id codes1Y32, 2GD3, 5GIW
Databases
NCBI: entry; OMA: entry
Ensembl
ENSG00000210082
Entrez
4550
External IDs
OMIM: 561010; MGI: 102492; GeneCards: RNR2

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Overview

Gene

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Function

Interactions

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Research

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Map overview Semantic statistics

Humanin

Nodes48
Edges47
Triples76
Avg. degree1.96
Density0.041667
Components1

How this topic connects Entity context

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Humanin

Top relations

Gene ontology · 15
Humanin → apoptotic process, cellular iron ion homeostasis, cytoplasm, extracellular negative regulation of signal transduction, extracellular region, G protein-coupled receptor signaling pathway, leukocyte chemotaxis, mitochondrion, negative regulation of apoptotic process, negative regulation of execution phase of apoptosis, negative regulation of signaling receptor activity, perinuclear region of cytoplasm, protein binding, receptor antagonist activity, signaling receptor binding
related to Discovery · 8
Humanin → Alzheimer's, Bax, Bcl-2-associated, IGFBP3, Nishimoto, The, The Pinchas Cohen, The Reed
related to Interactions · 7
Humanin → BAX, CNTFR, Extracellular, IGFBP3, Intracellular, TRIM11, WSX1
related to Other species · 7
Humanin → C0HLU6, Caenorhabditis, Humanin-like, Of, Overexpression, Rattus, The
related to Gene · 6
Humanin → DNA, It, MT-RNR2, MTRNR2L, Multiple, RNA
related to Research · 5
Humanin → Alzheimer's, Experiments, Huntington's, In, Studies
see also · 4
Humanin → MOTS-c, PEPITEM, Small, Thymosin
related to Function · 3
Humanin → Alzheimer's, Huntington's, Parkinson's
Aliases · 1
Humanin → RNR2, mitochondrially encoded 16S RNA, MTRNR2
Available structures · 1
Humanin → Available structuresPDBHuman UniProt search: PDBe RCSB List of PDB id codes1Y32, 2GD3, 5GIW

Important terminology Word statistics

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Important terminology

effects found peptide amino mitochondrial gene also neuroprotective peptides alzheimer's disease activity 16s protein sequence genome models cytoprotective mt-rnr2 encoded

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
HumaninAliasesRNR2, mitochondrially encoded 16S RNA, MTRNR21.00infobox
HumaninAvailable structuresAvailable structuresPDBHuman UniProt search: PDBe RCSB List of PDB id codes1Y32, 2GD3, 5GIW1.00infobox
HumaninDatabasesNCBI: entry; OMA: entry1.00infobox
HumaninEnsemblENSG000002100821.00infobox
HumaninEntrez45501.00infobox
HumaninExternal IDsOMIM: 561010; MGI: 102492; GeneCards: RNR21.00infobox
HumaninGene ontologysignaling receptor binding1.00infobox
HumaninGene ontologyprotein binding1.00infobox
HumaninGene ontologyreceptor antagonist activity1.00infobox
HumaninGene ontologycytoplasm1.00infobox
HumaninGene ontologyperinuclear region of cytoplasm1.00infobox
HumaninGene ontologyextracellular region1.00infobox
HumaninGene ontologymitochondrion1.00infobox
HumaninGene ontologynegative regulation of apoptotic process1.00infobox
HumaninGene ontologyleukocyte chemotaxis1.00infobox
HumaninGene ontologycellular iron ion homeostasis1.00infobox
HumaninGene ontologyapoptotic process1.00infobox
HumaninGene ontologyextracellular negative regulation of signal transduction1.00infobox
HumaninGene ontologyG protein-coupled receptor signaling pathway1.00infobox
HumaninGene ontologynegative regulation of execution phase of apoptosis1.00infobox
HumaninGene ontologynegative regulation of signaling receptor activity1.00infobox
HumaninList of PDB id codesList of PDB id codes1Y32, 2GD3, 5GIW1.00infobox
HumaninLocation (UCSC)n/a1.00infobox
HumaninOrthologsOrthologsDatabasesNCBI: entry; OMA: entrySpeciesHumanMouseEntrez455017725EnsemblENSG00000210082ENSMUSG00000064339UniProtQ8IVG9n/aRefSeq (mRNA)n/an/aRefSeq (protein)n/an/aLocatio…1.00infobox
HumaninPDBHuman UniProt search: PDBe RCSB1.00infobox
HumaninRefSeq (mRNA)n/a1.00infobox
HumaninRefSeq (protein)n/a1.00infobox
HumaninSpeciesHuman1.00infobox
HumaninUniProtQ8IVG91.00infobox
Humaninis amicropeptide encoded in the mitochondrial genome by the 16S ribosomal RNA gene0.90text

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