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The heteronuclear single quantum coherence or heteronuclear single quantum correlation experiment, normally abbreviated as HSQC, is used frequently in NMR spectroscopy of organic molecules and is of particular significance in the field of protein NMR. The experiment was first described by Geoffrey Bodenhausen and D. J. Ruben in 1980. The resulting…
Art, HSQC in protein NMR & General scheme
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hsqc protein nmr experiment 15n spectrum 1h peaks normally proton 13c also peak attached experiments used usually 31p residue structure
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| 1H | instance of | but is also applicable to other nuclei | 0.80 | text |
| structure determination | instance of | The assignment of the spectrum is essential for a meaningful interpretation of more advanced NMR experiments | 0.80 | text |
| relaxation analysis.Chemicals labelled with 15N isotope are relatively inexpensive | instance of | The assignment of the spectrum is essential for a meaningful interpretation of more advanced NMR experiments | 0.80 | text |
| and the 15N HSQC is a sensitive experiment whereby a spectrum can be acquired in a relatively short time | instance of | The assignment of the spectrum is essential for a meaningful interpretation of more advanced NMR experiments | 0.80 | text |
| the 15N HSQC is therefore often used to screen candidates for their suitability for structure determination by NMR | instance of | The assignment of the spectrum is essential for a meaningful interpretation of more advanced NMR experiments | 0.80 | text |
| as well as optimization of the sample conditions | instance of | The assignment of the spectrum is essential for a meaningful interpretation of more advanced NMR experiments | 0.80 | text |
| drugs | instance of | as well the interactions with ligands | 0.80 | text |
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