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High-content screening

High-content screening (HCS), also known as high-content analysis (HCA) or cellomics, is a method that is used in biological research and drug discovery to identify substances such as small molecules, peptides, or RNAi that alter the phenotype of a cell in a desired manner. Hence high content screening is a type of phenotypic screen conducted in cells…

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General principles

Instrumentation

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High-content screening

Nodes48
Edges47
Triples32
Avg. degree1.96
Density0.041667
Components1

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High-content screening

Top relations

related to General principles · 11
High-content screening → Activation, Cells, Changes, For, G-protein, GPCRs, HCS, High, High-content, RNAi, The
related to Instrumentation · 6
High-content screening → HCS, High-content, IT-systems, Spatially, These, This
related to history · 3
High-content screening → First, For, High-content

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Important terminology

cell screening analysis cells used automated hcs high high-content image changes fluorescent content biological microscopy biology technology drug using data

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
small moleculesinstance ofis a method that is used in biological research and drug discovery to identify substances0.80text
peptidesinstance ofis a method that is used in biological research and drug discovery to identify substances0.80text
or RNAi that alter the phenotype of a cell in a desired mannerinstance ofis a method that is used in biological research and drug discovery to identify substances0.80text
proteins and/or changes in the morphologyinstance ofPhenotypic changes may include increases or decreases in the production of cellular products0.80text
the green fluorescent proteins fused to endogenous proteinsinstance ofChanges in the amounts of proteins synthesized by cells are measured using a variety of techniques0.80text
or by fluorescent antibodies.The technology may be used to determine whether a potential drug is disease modifyinginstance ofChanges in the amounts of proteins synthesized by cells are measured using a variety of techniques0.80text
confocalinstance ofand additional imaging modes0.80text
bright fieldinstance ofand additional imaging modes0.80text
phase contrastinstance ofand additional imaging modes0.80text
FRETinstance ofand additional imaging modes0.80text
how much protein is in the nucleusinstance ofcameras for research created the opportunity to measure features in pictures of cells-0.80text
how much is outsideinstance ofcameras for research created the opportunity to measure features in pictures of cells-0.80text

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