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Heteronuclear single quantum coherence spectroscopy: Art, HSQC in protein NMR & General scheme

The heteronuclear single quantum coherence or heteronuclear single quantum correlation experiment, normally abbreviated as HSQC, is used frequently in NMR spectroscopy of organic molecules and is of particular significance in the field of protein NMR. The experiment was first described by Geoffrey Bodenhausen and D. J. Ruben in 1980. The resulting…

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Heteronuclear single quantum coherence spectroscopy topic overview

The analysis highlights Art, HSQC in protein NMR and General scheme as prominent areas in the source structure around Heteronuclear single quantum coherence spectroscopy.

Related topics
29
Source areas
3
Connected nodes
32
Extracted relationships
7
Related term clusters
10
Bridge connections
32

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

HSQC in protein NMR · 20 topics
Overview · 6 topics
General scheme · 3 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

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Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

General scheme

HSQC in protein NMR

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Advanced semantic analysis

How Heteronuclear single quantum coherence spectroscopy connects Entity context

See recurring relationship patterns around Heteronuclear single quantum coherence spectroscopy before inspecting the individual extracted relationships.

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

hsqc protein nmr experiment 15n spectrum 1h peaks normally proton 13c also peak attached experiments used usually 31p residue structure

Heteronuclear single quantum coherence spectroscopy relationships Subject–Predicate–Object triples

TTTA extracted 7 structured relationships around Heteronuclear single quantum coherence spectroscopy. Examples in this analysis include 1H → instance of → but is also applicable to other nuclei and structure determination → instance of → The assignment of the spectrum is essential for a meaningful interpretation of more advanced NMR experiments. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
1Hinstance ofbut is also applicable to other nuclei0.80text
structure determinationinstance ofThe assignment of the spectrum is essential for a meaningful interpretation of more advanced NMR experiments0.80text
relaxation analysis.Chemicals labelled with 15N isotope are relatively inexpensiveinstance ofThe assignment of the spectrum is essential for a meaningful interpretation of more advanced NMR experiments0.80text
and the 15N HSQC is a sensitive experiment whereby a spectrum can be acquired in a relatively short timeinstance ofThe assignment of the spectrum is essential for a meaningful interpretation of more advanced NMR experiments0.80text
the 15N HSQC is therefore often used to screen candidates for their suitability for structure determination by NMRinstance ofThe assignment of the spectrum is essential for a meaningful interpretation of more advanced NMR experiments0.80text
as well as optimization of the sample conditionsinstance ofThe assignment of the spectrum is essential for a meaningful interpretation of more advanced NMR experiments0.80text
drugsinstance ofas well the interactions with ligands0.80text

Related concept clusters Related term clusters

The concept neighborhoods around Heteronuclear single quantum coherence spectroscopy bring nearby vocabulary together. In this analysis, examples include Protein, Structure and 15n. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • nmr
    • Protein
    • Structure
    • 15n
    • Used
    • Experiments
    • Normally
    • Sample
    • Spectrum
    • Determination
    • Also
    • 2d
    • One
  • protein nmr
    • Protein
    • Structure
    • 15n
    • Used
    • Experiments
    • Normally
    • Sample
    • Peaks
    • Spectrum
    • Determination
    • Also
    • One
  • 13c
    • 1h
    • 15n
    • Signal
    • 31p
    • Experiment
    • Proton
    • 2d
    • Heteronucleus
    • Magnetization
    • One
    • Constant
    • May
  • 15n
    • Experiment
    • Hsqc
    • Proteins
    • Nmr
    • Spectrum
    • Used
    • 1h
    • Experiments
    • Protein
    • One
    • Particular
    • 31p
  • protein
    • 15n
    • Peaks
    • One
    • Proteins
    • Residue
    • Amide
    • Used
    • Usually
    • Spectrum
    • 31p
    • Assignment
    • May
  • hsqc in protein nmr
    • Protein
    • 15n
    • Nmr
    • Used
    • Structure
    • Normally
    • Experiments
    • Spectrum
    • Also
    • 1h
    • Sample
    • Peaks
  • triple resonance experiments
    • Recorded
    • Assignment
    • Nmr
    • Hsqc
    • Spectrum
    • One
    • Particular
    • Signal
    • Determination
    • Proteins
    • Resonances
    • Structure
  • ionization constant
    • Time
    • Used
    • Magnetization
    • Signal
    • Determination
    • May
    • Proteins
    • Due
    • Hsqc
    • Normally
    • Experiment

Connections between topic areas Semantic bridges

For Heteronuclear single quantum coherence spectroscopy, one of the stronger structural bridges in this analysis connects Heteronuclear single quantum coherence spectroscopy with HSQC in protein NMR. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Heteronuclear single quantum coherence spectroscopy — HSQC in protein NMR · splits 12 ⟂ 21
Heteronuclear single quantum coherence spectroscopy — Overview · splits 26 ⟂ 7
Heteronuclear single quantum coherence spectroscopy — General scheme · splits 29 ⟂ 4

Map overview Semantic statistics

Heteronuclear single quantum coherence spectroscopy

Nodes33
Edges32
Triples7
Avg. degree1.94
Density0.060606
Components1

Source & methodology

TTTA analyzes the structure around Heteronuclear single quantum coherence spectroscopy to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Art, HSQC in protein NMR & General scheme, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Heteronuclear single quantum coherence spectroscopy · EN edition · Analysis: TopicsToTalkAbout

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