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Glutathione peroxidase 1

Glutathione peroxidase 1, also known as GPx1, is an enzyme that in humans is encoded by the GPX1 gene on chromosome 3. This gene encodes a member of the glutathione peroxidase family. Glutathione peroxidase functions in the detoxification of hydrogen peroxide, and is one of the most important antioxidant enzymes in humans.

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1.11.1.12
↗
1.11.1.9
↗
Aliases
GPX1, GPXD, GSHPX1, glutathione peroxidase 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2F8A
Band
3p21.31 · 9 F2|9 59.24 cM
Bgee
monocyte · blood · granulocyte · right adrenal gland · right adrenal cortex

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Glutathione peroxidase 1

Nodes49
Edges48
Triples119
Avg. degree1.96
Density0.040816
Components1

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Glutathione peroxidase 1

Top relations

Gene ontology · 57
Glutathione peroxidase 1 → angiogenesis involved in wound healing, apoptotic process, biological process involved in interaction with symbiont, blood vessel endothelial cell migration, cell population proliferation, cell redox homeostasis, cellular oxidant detoxification, cellular response to oxidative stress, cytoplasm, cytosol, endothelial cell development, fat cell differentiation, glutathione metabolic process, glutathione peroxidase activity, hearing, heart contraction, hydrogen peroxide catabolic process, intrinsic apoptotic signaling pathway in response to oxidative stress, Lewy body, lipid metabolism
Bgee · 18
Glutathione peroxidase 1 → blood, bone marrow, cervix, fetal liver hematopoietic progenitor cell, gonad, granulocyte, human fetus, left adrenal cortex, left lobe of liver, monocyte, right adrenal cortex, right adrenal gland, right kidney, right lung, spleen, subcutaneous adipose tissue, submandibular gland, tibiofemoral joint
RNA expression pattern · 18
Glutathione peroxidase 1 → blood, bone marrow, cervix, fetal liver hematopoietic progenitor cell, gonad, granulocyte, human fetus, left adrenal cortex, left lobe of liver, monocyte, right adrenal cortex, right adrenal gland, right kidney, right lung, spleen, subcutaneous adipose tissue, submandibular gland, tibiofemoral joint
Band · 2
Glutathione peroxidase 1 → 3p21.31, 9 F2|9 59.24 cM
Chr. · 2
Glutathione peroxidase 1 → Chromosome 3 (human), Chromosome 9 (mouse)
End · 2
Glutathione peroxidase 1 → 108,217,542 bp, 49,358,353 bp
1.11.1.12 · 1
Glutathione peroxidase 1 → ↗
1.11.1.9 · 1
Glutathione peroxidase 1 → ↗
Aliases · 1
Glutathione peroxidase 1 → GPX1, GPXD, GSHPX1, glutathione peroxidase 1
Available structures · 1
Glutathione peroxidase 1 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2F8A

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Important terminology

gpx1 glutathione gene peroxidase expression cells oxidative bp stress human endothelial chromosome chr band cancer humans protein mitochondria polymorphism allele

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Glutathione peroxidase 11.11.1.12↗1.00infobox
Glutathione peroxidase 11.11.1.9↗1.00infobox
Glutathione peroxidase 1AliasesGPX1, GPXD, GSHPX1, glutathione peroxidase 11.00infobox
Glutathione peroxidase 1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2F8A1.00infobox
Glutathione peroxidase 1Band3p21.311.00infobox
Glutathione peroxidase 1Band9 F2|9 59.24 cM1.00infobox
Glutathione peroxidase 1Bgeemonocyte1.00infobox
Glutathione peroxidase 1Bgeeblood1.00infobox
Glutathione peroxidase 1Bgeegranulocyte1.00infobox
Glutathione peroxidase 1Bgeeright adrenal gland1.00infobox
Glutathione peroxidase 1Bgeeright adrenal cortex1.00infobox
Glutathione peroxidase 1Bgeeleft adrenal cortex1.00infobox
Glutathione peroxidase 1Bgeegonad1.00infobox
Glutathione peroxidase 1Bgeeright lung1.00infobox
Glutathione peroxidase 1Bgeespleen1.00infobox
Glutathione peroxidase 1Bgeesubcutaneous adipose tissue1.00infobox
Glutathione peroxidase 1Bgeefetal liver hematopoietic progenitor cell1.00infobox
Glutathione peroxidase 1Bgeeright kidney1.00infobox
Glutathione peroxidase 1Bgeeleft lobe of liver1.00infobox
Glutathione peroxidase 1Bgeetibiofemoral joint1.00infobox
Glutathione peroxidase 1Bgeehuman fetus1.00infobox
Glutathione peroxidase 1Bgeecervix1.00infobox
Glutathione peroxidase 1Bgeesubmandibular gland1.00infobox
Glutathione peroxidase 1Bgeebone marrow1.00infobox
Glutathione peroxidase 1BioGPSn/a1.00infobox
Glutathione peroxidase 1Chr.Chromosome 3 (human)1.00infobox
Glutathione peroxidase 1Chr.Chromosome 9 (mouse)1.00infobox
Glutathione peroxidase 1DatabasesNCBI: entry; OMA: entry1.00infobox
Glutathione peroxidase 1End49,358,353 bp1.00infobox
Glutathione peroxidase 1End108,217,542 bp1.00infobox

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