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Fukutin: Clinical significance, Function & Structure

Fukutin is a protein that in humans is encoded by the FKTN gene. It is necessary for the maintenance of muscle integrity, cortical histogenesis, and normal ocular development. In humans this protein is encoded by the FCMD gene (also named FKTN), located on chromosome9q31. The FKTN gene encodes a type II transmembrane protein that is central to the Golgi…

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Fukutin topic overview

The analysis highlights Clinical significance, Function and Structure as prominent areas in the source structure around Fukutin.

Related topics
34
Source areas
5
Connected nodes
39
Extracted relationships
157
Concept neighborhoods
16
Bridge connections
39

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Clinical significance · 12 topics
Function · 8 topics
Overview · 8 topics
Structure · 5 topics
Discovery · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
FKTN, CMD1X, FCMD, LGMD2M, MDDGA4, MDDGB4, MDDGC4, fukutin, LGMDR13
Band
9q31.2 · 4 B2|4 28.74 cM
Bgee
Achilles tendon · germinal epithelium · testicle · ventricular zone · skin of hip
BioGPS
n/a
Chr.
Chromosome 9 (human) · Chromosome 4 (mouse)
Databases
NCBI: entry; OMA: entry

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Discovery

Function

Structure

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Fukutin connects Entity context

The extracted context around Fukutin shows recurring relationship patterns in the source. For example, Fukutin → Achilles tendon, body of pancreas, corpus callosum, Epithelium of choroid plexus, epithelium of lens, germinal epithelium, interventricular septum, mucosa of paranasal sinus, olfactory epithelium, Region I of hippocampus proper, Rostral migratory stream, seminal vesicula, skin of hip, spermatocyte, stromal cell of endometrium, substantia nigra, testicle, trigeminal ganglion, ventricular zone, vestibular membrane of cochlear duct Another extracted example is Fukutin → cis-Golgi network, cytoplasm, endoplasmic reticulum, extracellular space, Golgi apparatus, Golgi membrane, integral component of Golgi membrane, integral component of membrane, membrane, muscle organ development, negative regulation of cell population proliferation, negative regulation of JNK cascade, nervous system development, nucleus, protein binding, protein glycosylation, protein O-linked glycosylation, protein O-linked mannosylation, regulation of protein glycosylation, transferase activity. Use these groups to spot repeated connection types before inspecting the individual relationships.

Fukutin

Top relations

Bgee · 20
Fukutin → Achilles tendon, body of pancreas, corpus callosum, Epithelium of choroid plexus, epithelium of lens, germinal epithelium, interventricular septum, mucosa of paranasal sinus, olfactory epithelium, Region I of hippocampus proper, Rostral migratory stream, seminal vesicula, skin of hip, spermatocyte, stromal cell of endometrium, substantia nigra, testicle, trigeminal ganglion, ventricular zone, vestibular membrane of cochlear duct
Gene ontology · 20
Fukutin → cis-Golgi network, cytoplasm, endoplasmic reticulum, extracellular space, Golgi apparatus, Golgi membrane, integral component of Golgi membrane, integral component of membrane, membrane, muscle organ development, negative regulation of cell population proliferation, negative regulation of JNK cascade, nervous system development, nucleus, protein binding, protein glycosylation, protein O-linked glycosylation, protein O-linked mannosylation, regulation of protein glycosylation, transferase activity
RNA expression pattern · 20
Fukutin → Achilles tendon, body of pancreas, corpus callosum, Epithelium of choroid plexus, epithelium of lens, germinal epithelium, interventricular septum, mucosa of paranasal sinus, olfactory epithelium, Region I of hippocampus proper, Rostral migratory stream, seminal vesicula, skin of hip, spermatocyte, stromal cell of endometrium, substantia nigra, testicle, trigeminal ganglion, ventricular zone, vestibular membrane of cochlear duct
related to Clinical significance · 18
Fukutin → AP-1, CK, CMD1X, Cyclin D1, Defects, FKRP, Fukutin Related Protein, Fukutin- Related Protein, Fukuyama, LGMD2I/R9, LGMD2M, Limb- Girdle Muscular Dystrophy, R9, Suppressing, Type, Walker-Warburg, Walker-Warburg Syndrome, While
related to Discovery · 14
Fukutin → Atsuo Sasaki, FCMD, FKTN, Fukuyama, In, Japan, Japanese, Kazuhiro Kobayashi, Northern, Researchers, RT-PCR, Tatsushi Toda, The, They
related to Other disorders · 14
Fukutin → Absence, Defective, FKTN, Fukuyama, Japan, Lack, LGMD2M, Limb, Mutations, Progressive, The, These, This, Walker-Warburg
related to Function · 10
Fukutin → Although, AP-1, D1, DG, During, Golgi, It, Taken, The, This
related to Structure · 9
Fukutin → As, Fukutin's, Fukutins, Instead, Mg2, Regarding, Ribitol, The, This
related to Neurodegeneration · 4
Fukutin → GSK-3β, It, Suppression, This
is a · 3
Fukutin → crucial enzyme involved in modifying proteins, protein that in humans is encoded by the FKTN gene, putative transmembrane protein that is ubiquitously expressed

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

protein gene muscle fktn may function muscular glycosylation also dystroglycan brain dystrophy cell bp development human congenital expression chr band

Fukutin relationships Subject–Predicate–Object triples

TTTA extracted 157 structured relationships around Fukutin. Examples in this analysis include Fukutin → Aliases → FKTN, CMD1X, FCMD, LGMD2M, MDDGA4, MDDGB4, MDDGC4, fukutin, LGMDR13 and Fukutin → Band → 9q31.2. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
FukutinAliasesFKTN, CMD1X, FCMD, LGMD2M, MDDGA4, MDDGB4, MDDGC4, fukutin, LGMDR131.00infobox
FukutinBand9q31.21.00infobox
FukutinBand4 B2|4 28.74 cM1.00infobox
FukutinBgeeAchilles tendon1.00infobox
FukutinBgeegerminal epithelium1.00infobox
FukutinBgeetesticle1.00infobox
FukutinBgeeventricular zone1.00infobox
FukutinBgeeskin of hip1.00infobox
FukutinBgeeRegion I of hippocampus proper1.00infobox
FukutinBgeemucosa of paranasal sinus1.00infobox
FukutinBgeestromal cell of endometrium1.00infobox
FukutinBgeebody of pancreas1.00infobox
FukutinBgeecorpus callosum1.00infobox
FukutinBgeeepithelium of lens1.00infobox
FukutinBgeeseminal vesicula1.00infobox
FukutinBgeeRostral migratory stream1.00infobox
FukutinBgeeEpithelium of choroid plexus1.00infobox
FukutinBgeeinterventricular septum1.00infobox
FukutinBgeetrigeminal ganglion1.00infobox
FukutinBgeeolfactory epithelium1.00infobox
FukutinBgeespermatocyte1.00infobox
FukutinBgeevestibular membrane of cochlear duct1.00infobox
FukutinBgeesubstantia nigra1.00infobox
FukutinBioGPSn/a1.00infobox
FukutinChr.Chromosome 9 (human)1.00infobox
FukutinChr.Chromosome 4 (mouse)1.00infobox
FukutinDatabasesNCBI: entry; OMA: entry1.00infobox
FukutinEnd105,653,820 bp1.00infobox
FukutinEnd53,777,890 bp1.00infobox
FukutinEnsemblENSG000001066921.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Fukutin bring nearby vocabulary together. In this analysis, examples include Gene, Protein and Function. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Fukutin
    • Gene
    • Protein
    • Function
    • May
    • Cell
    • Also
    • Glycosylation
    • Expression
    • Muscular
    • Muscle
    • Role
    • Fktn
  • fukutin
    • Gene
    • Protein
    • Function
    • May
    • Cell
    • Also
    • Glycosylation
    • Expression
    • Muscular
    • Muscle
    • Role
    • Fktn
  • protein
    • Function
    • Muscular
    • Congenital
    • Glycosylation
    • Dystrophy
    • Golgi
    • Researchers
    • Transmembrane
    • Fukuyama
    • Cell
    • May
    • Type
  • gene
    • Protein
    • Muscular
    • Dystrophy
    • Fukuyama
    • Congenital
    • Researchers
    • Also
    • Chromosome
    • Cell
    • Fcmd
    • Muscle
    • Bp
  • muscle
    • Alpha-
    • Dystroglycan
    • Matrix
    • Development
    • Glycosylation
    • Brain
    • Function
    • Muscular
    • May
    • Protein
    • Chromosome
    • Normal
  • chromosome
    • Bp
    • Human
    • Band
    • Mouse
    • Fktn
    • Researchers
    • Gene
    • Function
    • Encoded
    • Fcmd
    • Golgi
    • Membrane
  • fukuyama congenital muscular dystrophy
    • Muscular
    • Dystrophy
    • Congenital
    • Fukuyama
    • Type
    • Gene
    • Defects
    • Protein
    • Researchers
    • Fktn
    • Glycosylation
    • Mouse
  • fukutin- related protein
    • Function
    • Muscular
    • Congenital
    • Glycosylation
    • Dystrophy
    • Golgi
    • Researchers
    • Transmembrane
    • Fukuyama
    • Cell
    • May
    • Type

Connections between topic areas Semantic bridges

For Fukutin, one of the stronger structural bridges in this analysis connects Fukutin with Clinical significance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
FukutinClinical significance · splits 27 ⟂ 13
FukutinOverview · splits 31 ⟂ 9
FukutinFunction · splits 31 ⟂ 9
FukutinStructure · splits 34 ⟂ 6

Map overview Semantic statistics

Fukutin

Nodes40
Edges39
Triples157
Avg. degree1.95
Density0.05
Components1

Source & methodology

TTTA analyzes the structure around Fukutin to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Clinical significance, Function & Structure, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Fukutin · EN edition · Analysis: TopicsToTalkAbout

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