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Floxing

In genetic engineering, floxing refers to the insertion of a DNA sequence (which is then said to be floxed) between two LoxP sequences, creating an artificial gene cassette which can then be conditionally deleted (knocked out), translocated, or inverted in a process called Cre-Lox recombination. Recombination between LoxP sites is catalysed by Cre…

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Floxing

Nodes29
Edges28
Triples14
Avg. degree1.93
Density0.068966
Components1

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Floxing

Top relations

related to Mechanism of deletion · 6
Floxing → Cre-LoxP, Deletion, DNA, FRT/Flp, The, The Cre
related to Uses in research · 4
Floxing → Cre-Lox, In, The, This

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Important terminology

gene loxp cre recombinase genes recombination development sites expression cre-lox dna floxed allows used inverted using model researchers system specific

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
mice in order to study human diseasesinstance ofThe Cre-Lox system is widely used to manipulate gene expression in model organisms0.80text
drug developmentinstance ofThe Cre-Lox system is widely used to manipulate gene expression in model organisms0.80text
heat shock protein 70instance ofwhich leads to incorrect localization through its interactions with chaperone proteins0.80text
90instance ofwhich leads to incorrect localization through its interactions with chaperone proteins0.80text
Floxingrelated to Mechanism of deletionDeletion0.60section
Floxingrelated to Mechanism of deletionThe Cre0.60section
Floxingrelated to Mechanism of deletionDNA0.60section
Floxingrelated to Mechanism of deletionThe0.60section
Floxingrelated to Mechanism of deletionCre-LoxP0.60section
Floxingrelated to Mechanism of deletionFRT/Flp0.60section
Floxingrelated to Uses in researchCre-Lox0.60section
Floxingrelated to Uses in researchThe0.60section

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