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Febuxostat: History & Applications

Febuxostat, sold under the brand name Uloric among others, is a medication used long-term to treat gout due to high uric acid levels. It is generally recommended only for people who cannot take allopurinol. It is taken by mouth.

Language: English [EN]
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Febuxostat topic overview

The analysis highlights History and Applications as prominent areas in the source structure around Febuxostat.

Related topics
44
Source areas
6
Connected nodes
50
Extracted relationships
89
Concept neighborhoods
19
Bridge connections
50

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Pharmacology · 19 topics
Overview · 12 topics
History · 7 topics
Drug interactions · 4 topics
Medical uses · 1 topics
Side effects · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
M04AA03 (WHO)
Bioavailability
≥84% absorbed
CAS Number
144060-53-7 N
ChEBI
CHEBI:31596

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Medical uses

Side effects

Drug interactions

Pharmacology

History

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Febuxostat connects Entity context

The extracted context around Febuxostat shows recurring relationship patterns in the source. For example, Febuxostat → Adenuric, Australia, Donifoxate, Egypt, Europe, Feburic, Goturic, Goutex, In Pakistan, Japan, Latin America, New Zealand, Pakistan, SJG, SOLACE Pharmaceuticals, Uloric, US Another extracted example is Febuxostat → April, Asia, Astellas, China, Europe, European, European Medicines Agency, FDA, February, Ipsen, Japanese, Menarini, Takeda, TAP Pharmaceuticals, Teijin, US. Use these groups to spot repeated connection types before inspecting the individual relationships.

Febuxostat

Top relations

related to Brand names · 17
Febuxostat → Adenuric, Australia, Donifoxate, Egypt, Europe, Feburic, Goturic, Goutex, In Pakistan, Japan, Latin America, New Zealand, Pakistan, SJG, SOLACE Pharmaceuticals, Uloric, US
related to history · 16
Febuxostat → April, Asia, Astellas, China, Europe, European, European Medicines Agency, FDA, February, Ipsen, Japanese, Menarini, Takeda, TAP Pharmaceuticals, Teijin, US
has effect · 8
Febuxostat → As, FDA, However, In November, Takeda, The, The FDA, These
related to Pharmacokinetics · 8
Febuxostat → After, CYP1A1, Elimination, One, P450, These, UGT1A1, When
related to Economics · 5
Febuxostat → In, NICE, UK, United States, US
Legal status · 3
Febuxostat → AU: S4 (Prescription only), EU: Rx-only, US: ℞-only
related to Mechanism of action · 3
Febuxostat → It, Thus, Xanthine
related to Medical uses · 3
Febuxostat → Clinical Excellence, Health, National Institute
3D model (JSmol) · 1
Febuxostat → Interactive image
AHFS/Drugs.com · 1
Febuxostat → Monograph

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

allopurinol drug xanthine acid oxidase effects uric recommended use approved side teijin heart-related people increased risk death compared 2009 include

Febuxostat relationships Subject–Predicate–Object triples

TTTA extracted 89 structured relationships around Febuxostat. Examples in this analysis include Febuxostat → 3D model (JSmol) → Interactive image and Febuxostat → AHFS/Drugs.com → Monograph. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Febuxostat3D model (JSmol)Interactive image1.00infobox
FebuxostatAHFS/Drugs.comMonograph1.00infobox
FebuxostatATC codeM04AA03 (WHO)1.00infobox
FebuxostatBioavailability≥84% absorbed1.00infobox
FebuxostatCAS Number144060-53-7 N1.00infobox
FebuxostatChEBICHEBI:315961.00infobox
FebuxostatChEMBLChEMBL1164729 Y1.00infobox
FebuxostatChemSpider118173 Y1.00infobox
FebuxostatCompTox Dashboard (EPA)DTXSID80486501.00infobox
FebuxostatDrugBankDB04854 N1.00infobox
FebuxostatECHA InfoCard100.207.3291.00infobox
FebuxostatElimination half-life~5–8 hours1.00infobox
FebuxostatExcretionUrine (~49%, mostly as metabolites, 3% as unchanged drug); feces (~45%, mostly as metabolites, 12% as unchanged drug)1.00infobox
FebuxostatFormulaC16H16N2O3S1.00infobox
FebuxostatIUPHAR/BPS68171.00infobox
FebuxostatKEGGD01206 Y1.00infobox
FebuxostatLegal statusAU: S4 (Prescription only)1.00infobox
FebuxostatLegal statusUS: ℞-only1.00infobox
FebuxostatLegal statusEU: Rx-only1.00infobox
FebuxostatLicense dataUS DailyMed: Febuxostat1.00infobox
FebuxostatMedlinePlusa6090201.00infobox
FebuxostatMetabolismvia CYP1A1, 1A2, 2C8, 2C9, UGT1A1, 1A8, 1A91.00infobox
FebuxostatMolar mass316.38 g·mol−11.00infobox
FebuxostatPregnancy categoryAU: B11.00infobox
FebuxostatProtein binding99.2% to albumin1.00infobox
FebuxostatPubChem CID1340181.00infobox
FebuxostatRoutes of administrationBy mouth1.00infobox
FebuxostatTrade namesUloric, Adenuric, others1.00infobox
FebuxostatUNII101V0R1N2E1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Febuxostat bring nearby vocabulary together. In this analysis, examples include Allopurinol, Clinical and Drug. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Febuxostat
    • Allopurinol
    • Clinical
    • Drug
    • Gout
    • Compared
    • Fda
    • Increased
    • Metabolites
    • People
    • Risk
    • Use
    • Heart-related
  • febuxostat
    • Allopurinol
    • Clinical
    • Drug
    • Gout
    • Compared
    • Fda
    • Increased
    • Metabolites
    • People
    • Risk
    • Use
    • Heart-related
  • allopurinol
    • Clinical
    • Compared
    • People
    • Cannot
    • Recommended
    • Risk
    • Febuxostat
    • Drug
    • Death
    • Fda
    • Increased
    • Heart-related
  • drug interactions
    • Gout
    • Clinical
    • Us
    • Febuxostat
    • Medical
    • Name
    • Names
    • Others
    • Pregnancy
    • Ipsen
    • Problems
    • Side
  • high uric acid levels
    • Uric
    • Xanthine
    • Brand
    • Name
    • Others
    • Oxidase
    • Gout
    • Inhibits
    • Uloric
    • Medical
    • Names
    • Pregnancy
  • uric acid
    • Uric
    • Xanthine
    • Brand
    • Name
    • Others
    • Oxidase
    • Gout
    • Inhibits
    • Uloric
    • Medical
    • Names
    • Pregnancy
  • dicarboxylic acid
    • Uric
    • Brand
    • Name
    • Others
    • Oxidase
    • Xanthine
    • Gout
    • Inhibits
    • Uloric
    • Medical
    • Names
    • Pregnancy
  • side effects
    • Include
    • Side
    • Increased
    • Medical
    • Name
    • Names
    • Others
    • Pregnancy
    • Uloric
    • Gout
    • Metabolites
    • Problems

Connections between topic areas Semantic bridges

For Febuxostat, one of the stronger structural bridges in this analysis connects Febuxostat with Pharmacology. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
FebuxostatPharmacology · splits 31 ⟂ 20
FebuxostatOverview · splits 38 ⟂ 13
FebuxostatHistory · splits 43 ⟂ 8
FebuxostatDrug interactions · splits 46 ⟂ 5

Map overview Semantic statistics

Febuxostat

Nodes51
Edges50
Triples89
Avg. degree1.96
Density0.039216
Components1

Source & methodology

TTTA analyzes the structure around Febuxostat to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History & Applications, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Febuxostat · EN edition · Analysis: TopicsToTalkAbout

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