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Febuxostat

Febuxostat, sold under the brand name Uloric among others, is a medication used long-term to treat gout due to high uric acid levels. It is generally recommended only for people who cannot take allopurinol. It is taken by mouth.

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
M04AA03 (WHO)
Bioavailability
≥84% absorbed
CAS Number
144060-53-7 N
ChEBI
CHEBI:31596

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Overview

Medical uses

Side effects

Drug interactions

Pharmacology

History

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Map overview Semantic statistics

Febuxostat

Nodes51
Edges50
Triples89
Avg. degree1.96
Density0.039216
Components1

How this topic connects Entity context

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Febuxostat

Top relations

related to Brand names · 17
Febuxostat → Adenuric, Australia, Donifoxate, Egypt, Europe, Feburic, Goturic, Goutex, In Pakistan, Japan, Latin America, New Zealand, Pakistan, SJG, SOLACE Pharmaceuticals, Uloric, US
related to history · 16
Febuxostat → April, Asia, Astellas, China, Europe, European, European Medicines Agency, FDA, February, Ipsen, Japanese, Menarini, Takeda, TAP Pharmaceuticals, Teijin, US
has effect · 8
Febuxostat → As, FDA, However, In November, Takeda, The, The FDA, These
related to Pharmacokinetics · 8
Febuxostat → After, CYP1A1, Elimination, One, P450, These, UGT1A1, When
related to Economics · 5
Febuxostat → In, NICE, UK, United States, US
Legal status · 3
Febuxostat → AU: S4 (Prescription only), EU: Rx-only, US: ℞-only
related to Mechanism of action · 3
Febuxostat → It, Thus, Xanthine
related to Medical uses · 3
Febuxostat → Clinical Excellence, Health, National Institute
3D model (JSmol) · 1
Febuxostat → Interactive image
AHFS/Drugs.com · 1
Febuxostat → Monograph

Important terminology Word statistics

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Important terminology

allopurinol drug xanthine acid oxidase effects uric recommended use approved side teijin heart-related people increased risk death compared 2009 include

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Febuxostat3D model (JSmol)Interactive image1.00infobox
FebuxostatAHFS/Drugs.comMonograph1.00infobox
FebuxostatATC codeM04AA03 (WHO)1.00infobox
FebuxostatBioavailability≥84% absorbed1.00infobox
FebuxostatCAS Number144060-53-7 N1.00infobox
FebuxostatChEBICHEBI:315961.00infobox
FebuxostatChEMBLChEMBL1164729 Y1.00infobox
FebuxostatChemSpider118173 Y1.00infobox
FebuxostatCompTox Dashboard (EPA)DTXSID80486501.00infobox
FebuxostatDrugBankDB04854 N1.00infobox
FebuxostatECHA InfoCard100.207.3291.00infobox
FebuxostatElimination half-life~5–8 hours1.00infobox
FebuxostatExcretionUrine (~49%, mostly as metabolites, 3% as unchanged drug); feces (~45%, mostly as metabolites, 12% as unchanged drug)1.00infobox
FebuxostatFormulaC16H16N2O3S1.00infobox
FebuxostatIUPHAR/BPS68171.00infobox
FebuxostatKEGGD01206 Y1.00infobox
FebuxostatLegal statusAU: S4 (Prescription only)1.00infobox
FebuxostatLegal statusUS: ℞-only1.00infobox
FebuxostatLegal statusEU: Rx-only1.00infobox
FebuxostatLicense dataUS DailyMed: Febuxostat1.00infobox
FebuxostatMedlinePlusa6090201.00infobox
FebuxostatMetabolismvia CYP1A1, 1A2, 2C8, 2C9, UGT1A1, 1A8, 1A91.00infobox
FebuxostatMolar mass316.38 g·mol−11.00infobox
FebuxostatPregnancy categoryAU: B11.00infobox
FebuxostatProtein binding99.2% to albumin1.00infobox
FebuxostatPubChem CID1340181.00infobox
FebuxostatRoutes of administrationBy mouth1.00infobox
FebuxostatTrade namesUloric, Adenuric, others1.00infobox
FebuxostatUNII101V0R1N2E1.00infobox

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