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CD23

CD23, also known as Fc epsilon RII, or FcεRII, is the "low-affinity" receptor for IgE, an antibody isotype involved in allergy and resistance to parasites, and is important in regulation of IgE levels. Unlike many of the antibody receptors, CD23 is a C-type lectin. It is found on mature B cells, activated macrophages, eosinophils, follicular dendritic…

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Aliases
FCER2, BLAST-2, CD23, CD23A, CLEC4J, FCE2, IGEBF, Fc fragment of IgE receptor II, FCErII, Fc epsilon receptor II
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4KI1, 1T8C, 1T8D, 2H2R, 2H2T, 4EZM, 4G96, 4G9A, 4GI0, 4GJ0, 4GJX, 4GK1, 4GKO, 4J6J, 4J6K, 4J6L, 4J6M, 4J6N,…
Band
19p13.2 · 8 A1.1|8 1.92 cM
Bgee
testicle · granulocyte · spleen · lymph node · appendix
BioGPS
More reference expression data
Chr.
Chromosome 19 (human) · Chromosome 8 (mouse)

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Clinical significance

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Map overview Semantic statistics

CD23

Nodes26
Edges25
Triples100
Avg. degree1.92
Density0.076923
Components1

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CD23

Top relations

Gene ontology · 18
CD23 → carbohydrate binding, cytokine-mediated signaling pathway, external side of plasma membrane, extracellular exosome, extracellular region, IgE binding, integral component of membrane, integral component of plasma membrane, integrin binding, membrane, metal ion binding, Notch signaling pathway, plasma membrane, positive regulation of humoral immune response mediated by circulating immunoglobulin, positive regulation of killing of cells of other organism, positive regulation of nitric-oxide synthase activity, positive regulation of nitric-oxide synthase biosynthetic process, protein binding
Bgee · 17
CD23 → appendix, blood, bone marrow cell, embryo, granulocyte, lymph node, mesenteric lymph nodes, monocyte, morula, mucosa of transverse colon, spleen, subcutaneous adipose tissue, testicle, thymus, tibiofemoral joint, tonsil, white adipose tissue
RNA expression pattern · 17
CD23 → appendix, blood, bone marrow cell, embryo, granulocyte, lymph node, mesenteric lymph nodes, monocyte, morula, mucosa of transverse colon, spleen, subcutaneous adipose tissue, testicle, thymus, tibiofemoral joint, tonsil, white adipose tissue
related to Clinical significance · 16
CD23 → As CD23, B-cell, B-cells, CD23-negative, CD23-positive, Der, Fc, IgE, In, Lymphomas, Paradoxically, Recent, Reed, RI, Sternberg, The
related to Function · 7
CD23 → Antigens, CD11c, CD4, IgE, The, The CD11c, The IgE
Band · 2
CD23 → 19p13.2, 8 A1.1|8 1.92 cM
Chr. · 2
CD23 → Chromosome 19 (human), Chromosome 8 (mouse)
End · 2
CD23 → 3,744,175 bp, 7,702,146 bp
Aliases · 1
CD23 → FCER2, BLAST-2, CD23, CD23A, CLEC4J, FCE2, IGEBF, Fc fragment of IgE receptor II, FCErII, Fc epsilon receptor II
Available structures · 1
CD23 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4KI1, 1T8C, 1T8D, 2H2R, 2H2T, 4EZM, 4G96, 4G9A, 4GI0, 4GJ0, 4GJX, 4GK1, 4GKO, 4J6J, 4J6K, 4J6L, 4J6M, 4J6N,…

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Important terminology

cells ige human bp chr band antibody chromosome 19 receptor fc epsilon gene location cd23a known follicular fcer2 also external

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
CD23AliasesFCER2, BLAST-2, CD23, CD23A, CLEC4J, FCE2, IGEBF, Fc fragment of IgE receptor II, FCErII, Fc epsilon receptor II1.00infobox
CD23Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4KI1, 1T8C, 1T8D, 2H2R, 2H2T, 4EZM, 4G96, 4G9A, 4GI0, 4GJ0, 4GJX, 4GK1, 4GKO, 4J6J, 4J6K, 4J6L, 4J6M, 4J6N,…1.00infobox
CD23Band19p13.21.00infobox
CD23Band8 A1.1|8 1.92 cM1.00infobox
CD23Bgeetesticle1.00infobox
CD23Bgeegranulocyte1.00infobox
CD23Bgeespleen1.00infobox
CD23Bgeelymph node1.00infobox
CD23Bgeeappendix1.00infobox
CD23Bgeeblood1.00infobox
CD23Bgeemonocyte1.00infobox
CD23Bgeemucosa of transverse colon1.00infobox
CD23Bgeebone marrow cell1.00infobox
CD23Bgeetonsil1.00infobox
CD23Bgeemesenteric lymph nodes1.00infobox
CD23Bgeesubcutaneous adipose tissue1.00infobox
CD23Bgeeembryo1.00infobox
CD23Bgeethymus1.00infobox
CD23Bgeetibiofemoral joint1.00infobox
CD23Bgeewhite adipose tissue1.00infobox
CD23Bgeemorula1.00infobox
CD23BioGPSMore reference expression data1.00infobox
CD23Chr.Chromosome 19 (human)1.00infobox
CD23Chr.Chromosome 8 (mouse)1.00infobox
CD23DatabasesNCBI: entry; OMA: entry1.00infobox
CD23End7,702,146 bp1.00infobox
CD23End3,744,175 bp1.00infobox
CD23EnsemblENSG000001049211.00infobox
CD23Entrez22081.00infobox
CD23External IDsOMIM: 151445; MGI: 95497; GeneCards: FCER21.00infobox

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