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Estrone sulfate (medication): Pharmacology, Chemistry & Overview

Estrone sulfate (E1S) is an estrogen medication and naturally occurring steroid hormone. It is used in menopausal hormone therapy among other indications. As the sodium salt (sodium estrone sulfate), it is the major estrogen component of conjugated estrogens (Premarin) and esterified estrogens (Estratab, Menest). In addition, E1S is used on its own as…

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Estrone sulfate (medication) topic overview

The analysis highlights Pharmacology, Chemistry and Overview as prominent areas in the source structure around Estrone sulfate (medication).

Related topics
49
Source areas
3
Connected nodes
52
Extracted relationships
21
Related term clusters
34
Bridge connections
52

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Pharmacology · 21 topics
Overview · 17 topics
Chemistry · 11 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
CAS Number
481-97-0 Y 438-67-5 (sodium) 7280-37-7 (piperazine)
ChEBI
CHEBI:17474 Y
ChEMBL
ChEMBL494753 Y
ChemSpider
2272513 Y
Drug class
Estrogen; Estrogen ester

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Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Pharmacology

Chemistry

For the semantics nerds

You can skip this section if you’re here for content ideas and keyword inspiration.

Advanced semantic analysis

How Estrone sulfate (medication) connects Entity context

The extracted context around Estrone sulfate (medication) shows recurring relationship patterns in the source. For example, Estrone sulfate (medication) → Interactive image Another extracted example is Estrone sulfate (medication) → 481-97-0 Y 438-67-5 (sodium) 7280-37-7 (piperazine). Use these groups to spot repeated connection types before inspecting the individual relationships.

Estrone sulfate (medication)

Top relations

3D model (JSmol) · 1
Estrone sulfate (medication) → Interactive image
CAS Number · 1
Estrone sulfate (medication) → 481-97-0 Y 438-67-5 (sodium) 7280-37-7 (piperazine)
ChEBI · 1
Estrone sulfate (medication) → CHEBI:17474 Y
ChEMBL · 1
Estrone sulfate (medication) → ChEMBL494753 Y
ChemSpider · 1
Estrone sulfate (medication) → 2272513 Y
Drug class · 1
Estrone sulfate (medication) → Estrogen; Estrogen ester
DrugBank · 1
Estrone sulfate (medication) → DB04574 Y
Elimination half-life · 1
Estrone sulfate (medication) → 12 hours
Formula · 1
Estrone sulfate (medication) → C18H22O5S
IUPHAR/BPS · 1
Estrone sulfate (medication) → 4749

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

estrone estrogen e1s sulfate estradiol also steroid used sodium piperazine hormone premarin salt medication estrogens major estropipate parenteral metabolism half-life

Estrone sulfate (medication) relationships Subject–Predicate–Object triples

TTTA extracted 21 structured relationships around Estrone sulfate (medication). Examples in this analysis include Estrone sulfate (medication) → 3D model (JSmol) → Interactive image and Estrone sulfate (medication) → CAS Number → 481-97-0 Y 438-67-5 (sodium) 7280-37-7 (piperazine). The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Estrone sulfate (medication)3D model (JSmol)Interactive image1.00infobox
Estrone sulfate (medication)CAS Number481-97-0 Y 438-67-5 (sodium) 7280-37-7 (piperazine)1.00infobox
Estrone sulfate (medication)ChEBICHEBI:17474 Y1.00infobox
Estrone sulfate (medication)ChEMBLChEMBL494753 Y1.00infobox
Estrone sulfate (medication)ChemSpider2272513 Y1.00infobox
Estrone sulfate (medication)Drug classEstrogen; Estrogen ester1.00infobox
Estrone sulfate (medication)DrugBankDB04574 Y1.00infobox
Estrone sulfate (medication)Elimination half-life12 hours1.00infobox
Estrone sulfate (medication)FormulaC18H22O5S1.00infobox
Estrone sulfate (medication)IUPHAR/BPS47491.00infobox
Estrone sulfate (medication)MetabolismSulfation (via STSTooltip steroid sulfatase)1.00infobox
Estrone sulfate (medication)Metabolites• Estrone • Estradiol1.00infobox
Estrone sulfate (medication)Molar mass350.43 g·mol−11.00infobox
Estrone sulfate (medication)Other namesE1S; Oestrone sulfate; Estrone 3-sulfate; Estra-1,3,5(10)-trien-17-one 3-sulfate1.00infobox
Estrone sulfate (medication)Protein binding90%, to albumin, and not to SHBGTooltip sex hormone-binding globulin1.00infobox
Estrone sulfate (medication)PubChem CID30010281.00infobox
Estrone sulfate (medication)Routes of administrationBy mouth, others1.00infobox
Estrone sulfate (medication)UNIIQTL48N278K1.00infobox

Related concept clusters Related term clusters

The concept neighborhoods around Estrone sulfate (medication) bring nearby vocabulary together. In this analysis, examples include Sulfate, Estrogen and E1s. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Estrone sulfate (medication)
    • Sulfate
    • Estrogen
    • E1s
    • Steroid
    • Among
    • Estradiol
    • Indications
    • Menopausal
    • Prodrug
    • Estrogens
    • Piperazine
    • Sodium
  • estrone sulfate (medication)
    • Sulfate
    • Hormone
    • Estrogen
    • E1s
    • Steroid
    • Used
    • Among
    • Ester
    • Estradiol
    • Indications
    • Menopausal
    • Mouth
  • estrogen (medication)
    • Hormone
    • Estrone
    • Steroid
    • Sulfate
    • Used
    • Estradiol
    • Among
    • Ester
    • Half-life
    • Indications
    • Menopausal
    • Mouth
  • estradiol (medication)
    • Hormone
    • Steroid
    • Used
    • Glucuronide
    • Half-life
    • Metabolism
    • Oral
    • Reservoir
    • Estrogen
    • Among
    • Ester
    • Estrone
  • estrone (medication)
    • Sulfate
    • Hormone
    • Estrogen
    • E1s
    • Steroid
    • Used
    • Among
    • Ester
    • Estradiol
    • Indications
    • Menopausal
    • Mouth
  • estrogen receptor
    • Estrone
    • Sulfate
    • Estradiol
    • Half-life
    • Oral
    • Steroid
    • Ester
    • Pharmacokinetics
    • Estrogens
    • Glucuronide
    • Hormone
    • Medication
  • estrogen sulfotransferase
    • Estrone
    • Sulfate
    • Estradiol
    • Half-life
    • Oral
    • Steroid
    • Ester
    • Pharmacokinetics
    • Estrogens
    • Glucuronide
    • Hormone
    • Medication
  • estradiol glucuronide
    • Oral
    • Glucuronide
    • Half-life
    • Metabolism
    • Reservoir
    • Estrogen
    • Estrone
    • Important
    • Parenteral
    • Pharmacokinetics
    • Prodrug
    • Medication

Connections between topic areas Semantic bridges

For Estrone sulfate (medication), one of the stronger structural bridges in this analysis connects Estrone sulfate (medication) with Pharmacology. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Estrone sulfate (medication) — Pharmacology · splits 31 ⟂ 22
Estrone sulfate (medication) — Overview · splits 35 ⟂ 18
Estrone sulfate (medication) — Chemistry · splits 41 ⟂ 12

Map overview Semantic statistics

Estrone sulfate (medication)

Nodes53
Edges52
Triples21
Avg. degree1.96
Density0.037736
Components1

Source & methodology

TTTA analyzes the structure around Estrone sulfate (medication) to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Pharmacology, Chemistry & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Estrone sulfate (medication) · EN edition · Analysis: TopicsToTalkAbout

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