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Epistasis

Epistasis is a phenomenon in genetics in which the effect of a mutation on a trait is dependent on the presence or absence of mutations at different loci (locations on the genome), that may be on the same gene (intragenic) or on different genes, called modifier genes. In evolutionary genetics, epistasis occurs when the combined effect of two mutations is…

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Overview

History

Classification

Additivity

Genetic and molecular causes

Evolutionary consequences

Methods and model systems

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Map overview Semantic statistics

Epistasis

Nodes117
Edges116
Triples78
Avg. degree1.98
Density0.017094
Components1

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Epistasis

Top relations

related to history · 12
Epistasis → As, Because, Consequently, Florence Durham, For, However, In, Muriel Wheldale Onslow, Some, The, Understanding, William Bateson
related to Evolution of sex · 9
Epistasis → Alexey Kondrashov, Experimentally, However, In, It, Kondrashov, Negative, Over, This
related to External links · 8
Epistasis → Alevel, Epistasis High, GCSE, GeneticInteractions, GWIA, INTERSNP, Science Aid, SNP
related to Computational prediction · 7
Epistasis → Even, For, Hadamard, Many, MDR, Numerous, Several
related to Sign epistasis · 7
Epistasis → At, For, If, Mt Fuji, Reciprocal, Sign, The
related to Additivity · 5
Epistasis → For, However, It, Some, This
related to Classification · 5
Epistasis → Additionally, Confusion, In, Terminology, The
related to Double mutant cycles · 4
Epistasis → For, The, This, When
related to Magnitude epistasis · 4
Epistasis → Conversely, Negative, Positive, When
related to Epistasis between genes · 3
Epistasis → Alternatively, For, This

Important terminology Word statistics

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Important terminology

mutations fitness mutation two gene genes effects phenotype example different evolution genetics genetic landscape effect one deleterious may interactions loci

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Epistasiscausesa fitness landscape to be smooth0.90text
Epistasisis aphenomenon in genetics in which the effect of a mutation on a trait is dependent on the presence or absence of mutations at different loci0.90text
Epistasisis anecessary condition for ruggedness0.90text
linear regressioninstance ofMany of these rely on machine learning to detect non-additive effects that might be missed by statistical approaches0.80text
disease status in human populationsinstance ofwas designed specifically for nonparametric and model-free detection of combinations of genetic variants that are predictive of a phenotype0.80text
Epistasisrelated to AdditivityThis0.60section
Epistasisrelated to AdditivityFor0.60section
Epistasisrelated to AdditivityHowever0.60section
Epistasisrelated to AdditivitySome0.60section
Epistasisrelated to AdditivityIt0.60section
Epistasisrelated to ClassificationTerminology0.60section
Epistasisrelated to ClassificationAdditionally0.60section

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    Min side: 3
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