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EME1: Overview, Related Topics & Entities

Crossover junction endonuclease EME1 is an enzyme that is encoded by the EME1 gene in humans. It forms a complex with MUS81 which resolves Holliday junctions. In mammalian cells the EME1/MUS81 protein complex is redundant for DNA damage repair with GEN1 endonuclease. In mice, EME1/MUS81 and GEN1 redundantly contribute to Holliday junction processing.…

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EME1 topic overview

The analysis highlights Overview, Related Topics and Entities as prominent areas in the source structure around EME1.

Related topics
12
Source areas
1
Connected nodes
13
Extracted relationships
86
Concept neighborhoods
13
Bridge connections
13

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 12 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
EME1, MMS4L, SLX2A, essential meiotic structure-specific endonuclease 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2ZIU, 2ZIV, 2ZIW, 2ZIX, 4P0P, 4P0Q, 4P0R, 4P0S
Band
17q21.33 · 11|11 D
Bgee
tail of epididymis · corpus epididymis · tendon of biceps brachii · mucosa of ileum · pancreatic ductal cell
BioGPS
More reference expression data
Chr.
Chromosome 17 (human) · Chromosome 11 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How EME1 connects Entity context

The extracted context around EME1 shows recurring relationship patterns in the source. For example, EME1 → cellular response to DNA damage stimulus, crossover junction endodeoxyribonuclease activity, DNA binding, DNA recombination, DNA repair, double-strand break repair, endodeoxyribonuclease activity, endonuclease activity, Holliday junction resolvase complex, hydrolase activity, interstrand cross-link repair, metal ion binding, mitotic intra-S DNA damage checkpoint signaling, nuclease activity, nucleic acid phosphodiester bond hydrolysis, nucleolus, nucleoplasm, nucleus, protein binding, replication fork processing Another extracted example is EME1 → corpus epididymis, endothelial cell, epiblast, genital tubercle, lateral part of occipital bone, left testis, mandibular prominence, maxillary prominence, mucosa of ileum, oocyte, pancreatic ductal cell, right testis, secondary oocyte, somite, sphenoid bone, tail of embryo, tail of epididymis, tendon of biceps brachii, thyroid cartilage, yolk sac. Use these groups to spot repeated connection types before inspecting the individual relationships.

EME1

Top relations

Gene ontology · 22
EME1 → cellular response to DNA damage stimulus, crossover junction endodeoxyribonuclease activity, DNA binding, DNA recombination, DNA repair, double-strand break repair, endodeoxyribonuclease activity, endonuclease activity, Holliday junction resolvase complex, hydrolase activity, interstrand cross-link repair, metal ion binding, mitotic intra-S DNA damage checkpoint signaling, nuclease activity, nucleic acid phosphodiester bond hydrolysis, nucleolus, nucleoplasm, nucleus, protein binding, replication fork processing
Bgee · 20
EME1 → corpus epididymis, endothelial cell, epiblast, genital tubercle, lateral part of occipital bone, left testis, mandibular prominence, maxillary prominence, mucosa of ileum, oocyte, pancreatic ductal cell, right testis, secondary oocyte, somite, sphenoid bone, tail of embryo, tail of epididymis, tendon of biceps brachii, thyroid cartilage, yolk sac
RNA expression pattern · 20
EME1 → corpus epididymis, endothelial cell, epiblast, genital tubercle, lateral part of occipital bone, left testis, mandibular prominence, maxillary prominence, mucosa of ileum, oocyte, pancreatic ductal cell, right testis, secondary oocyte, somite, sphenoid bone, tail of embryo, tail of epididymis, tendon of biceps brachii, thyroid cartilage, yolk sac
Band · 2
EME1 → 11|11 D, 17q21.33
Chr. · 2
EME1 → Chromosome 11 (mouse), Chromosome 17 (human)
End · 2
EME1 → 50,381,483 bp, 94,544,790 bp
Aliases · 1
EME1 → EME1, MMS4L, SLX2A, essential meiotic structure-specific endonuclease 1
Available structures · 1
EME1 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2ZIU, 2ZIV, 2ZIW, 2ZIX, 4P0P, 4P0Q, 4P0R, 4P0S
BioGPS · 1
EME1 → More reference expression data
Databases · 1
EME1 → NCBI: entry; OMA: entry

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

gen1 dna bp mice chr repair human band endonuclease mus81 gene chromosome 17 redundant junction complex holliday meiotic homozygous mutations

EME1 relationships Subject–Predicate–Object triples

TTTA extracted 86 structured relationships around EME1. Examples in this analysis include EME1 → Aliases → EME1, MMS4L, SLX2A, essential meiotic structure-specific endonuclease 1 and EME1 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2ZIU, 2ZIV, 2ZIW, 2ZIX, 4P0P, 4P0Q, 4P0R, 4P0S. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
EME1AliasesEME1, MMS4L, SLX2A, essential meiotic structure-specific endonuclease 11.00infobox
EME1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2ZIU, 2ZIV, 2ZIW, 2ZIX, 4P0P, 4P0Q, 4P0R, 4P0S1.00infobox
EME1Band17q21.331.00infobox
EME1Band11|11 D1.00infobox
EME1Bgeetail of epididymis1.00infobox
EME1Bgeecorpus epididymis1.00infobox
EME1Bgeetendon of biceps brachii1.00infobox
EME1Bgeemucosa of ileum1.00infobox
EME1Bgeepancreatic ductal cell1.00infobox
EME1Bgeeoocyte1.00infobox
EME1Bgeeendothelial cell1.00infobox
EME1Bgeeright testis1.00infobox
EME1Bgeeleft testis1.00infobox
EME1Bgeesecondary oocyte1.00infobox
EME1Bgeelateral part of occipital bone1.00infobox
EME1Bgeegenital tubercle1.00infobox
EME1Bgeetail of embryo1.00infobox
EME1Bgeeepiblast1.00infobox
EME1Bgeesomite1.00infobox
EME1Bgeeyolk sac1.00infobox
EME1Bgeethyroid cartilage1.00infobox
EME1Bgeemaxillary prominence1.00infobox
EME1Bgeemandibular prominence1.00infobox
EME1Bgeesphenoid bone1.00infobox
EME1BioGPSMore reference expression data1.00infobox
EME1Chr.Chromosome 17 (human)1.00infobox
EME1Chr.Chromosome 11 (mouse)1.00infobox
EME1DatabasesNCBI: entry; OMA: entry1.00infobox
EME1End50,381,483 bp1.00infobox
EME1End94,544,790 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around EME1 bring nearby vocabulary together. In this analysis, examples include Endonuclease, Junction and Gen1. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • EME1
    • Endonuclease
    • Junction
    • Gen1
    • Gene
    • Repair
    • Dna
    • Damage
    • Processing
    • Protein
    • Search
    • Complex
    • Holliday
  • eme1
    • Endonuclease
    • Junction
    • Gen1
    • Gene
    • Repair
    • Dna
    • Damage
    • Processing
    • Protein
    • Search
    • Complex
    • Holliday
  • dna damage repair
    • Protein
    • Repair
    • Endonuclease
    • Gen1
    • Damage
    • Dna
    • Eme1
    • End
    • Mouse
    • Processing
    • Recombination
    • Redundant
  • dna damaging agents
    • Repair
    • Gen1
    • Damage
    • Protein
    • Eme1
    • Redundant
    • Endonuclease
    • Mice
    • Also
    • Emc1
    • End
    • Homozygous
  • holliday junctions
    • Processing
    • Junction
    • Mus81
    • Damage
    • End
    • Mouse
    • Protein
    • Recombination
    • Search
    • Location
    • Meiotic
    • Band
  • holliday junction
    • Processing
    • Junction
    • Mus81
    • Damage
    • End
    • Mouse
    • Protein
    • Recombination
    • Search
    • Location
    • Meiotic
    • Band
  • gene
    • Location
    • Chromosome
    • Human
    • Bp
    • Chr
    • End
    • Mouse
    • Search
    • Junction
    • Meiotic
    • Band
    • Damage
  • gen1
    • Mice
    • Redundant
    • Repair
    • Also
    • Emc1
    • Homozygous
    • Mutations
    • Mus81
    • Processing
    • Protein
    • Recombination
    • Holliday

Connections between topic areas Semantic bridges

Bridges highlight paths between different parts of the EME1 map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

Map overview Semantic statistics

EME1

Nodes14
Edges13
Triples86
Avg. degree1.86
Density0.142857
Components1

Source & methodology

TTTA analyzes the structure around EME1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Overview, Related Topics & Entities, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — EME1 · EN edition · Analysis: TopicsToTalkAbout

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