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Crossover junction endonuclease EME1 is an enzyme that is encoded by the EME1 gene in humans. It forms a complex with MUS81 which resolves Holliday junctions. In mammalian cells the EME1/MUS81 protein complex is redundant for DNA damage repair with GEN1 endonuclease. In mice, EME1/MUS81 and GEN1 redundantly contribute to Holliday junction processing.…
The analysis highlights Overview, Related Topics and Entities as prominent areas in the source structure around EME1.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around EME1 shows recurring relationship patterns in the source. For example, EME1 → cellular response to DNA damage stimulus, crossover junction endodeoxyribonuclease activity, DNA binding, DNA recombination, DNA repair, double-strand break repair, endodeoxyribonuclease activity, endonuclease activity, Holliday junction resolvase complex, hydrolase activity, interstrand cross-link repair, metal ion binding, mitotic intra-S DNA damage checkpoint signaling, nuclease activity, nucleic acid phosphodiester bond hydrolysis, nucleolus, nucleoplasm, nucleus, protein binding, replication fork processing Another extracted example is EME1 → corpus epididymis, endothelial cell, epiblast, genital tubercle, lateral part of occipital bone, left testis, mandibular prominence, maxillary prominence, mucosa of ileum, oocyte, pancreatic ductal cell, right testis, secondary oocyte, somite, sphenoid bone, tail of embryo, tail of epididymis, tendon of biceps brachii, thyroid cartilage, yolk sac. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
gen1 dna bp mice chr repair human band endonuclease mus81 gene chromosome 17 redundant junction complex holliday meiotic homozygous mutations
TTTA extracted 86 structured relationships around EME1. Examples in this analysis include EME1 → Aliases → EME1, MMS4L, SLX2A, essential meiotic structure-specific endonuclease 1 and EME1 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2ZIU, 2ZIV, 2ZIW, 2ZIX, 4P0P, 4P0Q, 4P0R, 4P0S. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| EME1 | Aliases | EME1, MMS4L, SLX2A, essential meiotic structure-specific endonuclease 1 | 1.00 | infobox |
| EME1 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2ZIU, 2ZIV, 2ZIW, 2ZIX, 4P0P, 4P0Q, 4P0R, 4P0S | 1.00 | infobox |
| EME1 | Band | 17q21.33 | 1.00 | infobox |
| EME1 | Band | 11|11 D | 1.00 | infobox |
| EME1 | Bgee | tail of epididymis | 1.00 | infobox |
| EME1 | Bgee | corpus epididymis | 1.00 | infobox |
| EME1 | Bgee | tendon of biceps brachii | 1.00 | infobox |
| EME1 | Bgee | mucosa of ileum | 1.00 | infobox |
| EME1 | Bgee | pancreatic ductal cell | 1.00 | infobox |
| EME1 | Bgee | oocyte | 1.00 | infobox |
| EME1 | Bgee | endothelial cell | 1.00 | infobox |
| EME1 | Bgee | right testis | 1.00 | infobox |
| EME1 | Bgee | left testis | 1.00 | infobox |
| EME1 | Bgee | secondary oocyte | 1.00 | infobox |
| EME1 | Bgee | lateral part of occipital bone | 1.00 | infobox |
| EME1 | Bgee | genital tubercle | 1.00 | infobox |
| EME1 | Bgee | tail of embryo | 1.00 | infobox |
| EME1 | Bgee | epiblast | 1.00 | infobox |
| EME1 | Bgee | somite | 1.00 | infobox |
| EME1 | Bgee | yolk sac | 1.00 | infobox |
| EME1 | Bgee | thyroid cartilage | 1.00 | infobox |
| EME1 | Bgee | maxillary prominence | 1.00 | infobox |
| EME1 | Bgee | mandibular prominence | 1.00 | infobox |
| EME1 | Bgee | sphenoid bone | 1.00 | infobox |
| EME1 | BioGPS | More reference expression data | 1.00 | infobox |
| EME1 | Chr. | Chromosome 17 (human) | 1.00 | infobox |
| EME1 | Chr. | Chromosome 11 (mouse) | 1.00 | infobox |
| EME1 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| EME1 | End | 50,381,483 bp | 1.00 | infobox |
| EME1 | End | 94,544,790 bp | 1.00 | infobox |
The concept neighborhoods around EME1 bring nearby vocabulary together. In this analysis, examples include Endonuclease, Junction and Gen1. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
Bridges highlight paths between different parts of the EME1 map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around EME1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Overview, Related Topics & Entities, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — EME1 · EN edition · Analysis: TopicsToTalkAbout