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DYNC1H1: Clinical relevance, Interactions & Overview

Cytoplasmic dynein 1 heavy chain 1 is a protein that in humans is encoded by the DYNC1H1 gene. Dynein is a molecular motor protein that is responsible for the transport of numerous cellular cargoes to minus ends of microtubules, which are typically found in the center of a cell, or the cell body of neurons. It is located on the 14th chromosome at…

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DYNC1H1 topic overview

The analysis highlights Clinical relevance, Interactions and Overview as prominent areas in the source structure around DYNC1H1.

Related topics
13
Source areas
3
Connected nodes
16
Extracted relationships
133
Related term clusters
8
Bridge connections
16

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Clinical relevance · 5 topics
Interactions · 4 topics
Overview · 4 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
DYNC1H1, DHC1, DHC1a, DNCH1, DNCL, DNECL, DYHC, Dnchc1, HL-3, SMALED1, p22, CMT2O, dynein cytoplasmic 1 heavy chain 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2BOR, 2BOT
Band
14q32.31 · 12 F1|12 60.7 cM
Bgee
ganglionic eminence · ventricular zone · prefrontal cortex · stromal cell of endometrium · right frontal lobe
BioGPS
More reference expression data
Chr.
Chromosome 14 (human) · Chromosome 12 (mouse)

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Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Interactions

Clinical relevance

For the semantics nerds

You can skip this section if you’re here for content ideas and keyword inspiration.

Advanced semantic analysis

How DYNC1H1 connects Entity context

The extracted context around DYNC1H1 shows recurring relationship patterns in the source. For example, DYNC1H1 → antigen processing and presentation of exogenous peptide antigen via MHC class II, ATP binding, ATPase activity, axon cytoplasm, azurophil granule lumen, cell cortex, cell cycle, cell division, centrosome, ciliary basal body-plasma membrane docking, cytoplasm, cytoplasmic dynein complex, cytoplasmic microtubule, cytoplasmic microtubule organization, cytoskeletal motor activity, cytoskeleton, cytosol, dynein complex, dynein intermediate chain binding, dynein light chain binding Another extracted example is DYNC1H1 → Brodmann area 9, C1 segment, CA3 field, central gray substance of midbrain, dentate gyrus of hippocampal formation granule cell, entorhinal cortex, external carotid artery, facial motor nucleus, ganglionic eminence, lateral nuclear group of thalamus, perirhinal cortex, postcentral gyrus, prefrontal cortex, primary visual cortex, right frontal lobe, right hemisphere of cerebellum, stromal cell of endometrium, superior frontal gyrus, ventricular zone. Use these groups to spot repeated connection types before inspecting the individual relationships.

DYNC1H1

Top relations

Gene ontology · 52
DYNC1H1 → antigen processing and presentation of exogenous peptide antigen via MHC class II, ATP binding, ATPase activity, axon cytoplasm, azurophil granule lumen, cell cortex, cell cycle, cell division, centrosome, ciliary basal body-plasma membrane docking, cytoplasm, cytoplasmic dynein complex, cytoplasmic microtubule, cytoplasmic microtubule organization, cytoskeletal motor activity, cytoskeleton, cytosol, dynein complex, dynein intermediate chain binding, dynein light chain binding
Bgee · 19
DYNC1H1 → Brodmann area 9, C1 segment, CA3 field, central gray substance of midbrain, dentate gyrus of hippocampal formation granule cell, entorhinal cortex, external carotid artery, facial motor nucleus, ganglionic eminence, lateral nuclear group of thalamus, perirhinal cortex, postcentral gyrus, prefrontal cortex, primary visual cortex, right frontal lobe, right hemisphere of cerebellum, stromal cell of endometrium, superior frontal gyrus, ventricular zone
RNA expression pattern · 19
DYNC1H1 → Brodmann area 9, C1 segment, CA3 field, central gray substance of midbrain, dentate gyrus of hippocampal formation granule cell, entorhinal cortex, external carotid artery, facial motor nucleus, ganglionic eminence, lateral nuclear group of thalamus, perirhinal cortex, postcentral gyrus, prefrontal cortex, primary visual cortex, right frontal lobe, right hemisphere of cerebellum, stromal cell of endometrium, superior frontal gyrus, ventricular zone
related to Clinical relevance · 14
DYNC1H1 → Amyotrophic, Another, Autosomal, Charcot-Marie-Tooth, Defects, Due, DYNC1H1-related, DYNC1H1-Related Disorders, Given, Mutations, Prior, Recent, September, SMA-LED1
related to Interactions · 4
DYNC1H1 → CDC5L, Dynactin, MDa, PAFAH1B1
Band · 2
DYNC1H1 → 12 F1|12 60.7 cM, 14q32.31
Chr. · 2
DYNC1H1 → Chromosome 12 (mouse), Chromosome 14 (human)
End · 2
DYNC1H1 → 102,056,443 bp, 110,633,379 bp
related to Society and Culture · 2
DYNC1H1 → DYNC1H1-related, The DYNC1H1 Association
Aliases · 1
DYNC1H1 → DYNC1H1, DHC1, DHC1a, DNCH1, DNCL, DNECL, DYHC, Dnchc1, HL-3, SMALED1, p22, CMT2O, dynein cytoplasmic 1 heavy chain 1

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

dynein gene bp cytoplasmic chain chromosome heavy chr human band protein disorders 14 cell dync1h1-related transport external motor location symptoms

DYNC1H1 relationships Subject–Predicate–Object triples

TTTA extracted 133 structured relationships around DYNC1H1. Examples in this analysis include DYNC1H1 → Aliases → DYNC1H1, DHC1, DHC1a, DNCH1, DNCL, DNECL, DYHC, Dnchc1, HL-3, SMALED1, p22, CMT2O, dynein cytoplasmic 1 heavy chain 1 and DYNC1H1 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2BOR, 2BOT. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
DYNC1H1AliasesDYNC1H1, DHC1, DHC1a, DNCH1, DNCL, DNECL, DYHC, Dnchc1, HL-3, SMALED1, p22, CMT2O, dynein cytoplasmic 1 heavy chain 11.00infobox
DYNC1H1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2BOR, 2BOT1.00infobox
DYNC1H1Band14q32.311.00infobox
DYNC1H1Band12 F1|12 60.7 cM1.00infobox
DYNC1H1Bgeeganglionic eminence1.00infobox
DYNC1H1Bgeeventricular zone1.00infobox
DYNC1H1Bgeeprefrontal cortex1.00infobox
DYNC1H1Bgeestromal cell of endometrium1.00infobox
DYNC1H1Bgeeright frontal lobe1.00infobox
DYNC1H1Bgeeright hemisphere of cerebellum1.00infobox
DYNC1H1BgeeBrodmann area 91.00infobox
DYNC1H1Bgeepostcentral gyrus1.00infobox
DYNC1H1Bgeelateral nuclear group of thalamus1.00infobox
DYNC1H1BgeeC1 segment1.00infobox
DYNC1H1Bgeedentate gyrus of hippocampal formation granule cell1.00infobox
DYNC1H1Bgeeprimary visual cortex1.00infobox
DYNC1H1BgeeCA3 field1.00infobox
DYNC1H1Bgeeentorhinal cortex1.00infobox
DYNC1H1Bgeesuperior frontal gyrus1.00infobox
DYNC1H1Bgeeperirhinal cortex1.00infobox
DYNC1H1Bgeeexternal carotid artery1.00infobox
DYNC1H1Bgeecentral gray substance of midbrain1.00infobox
DYNC1H1Bgeefacial motor nucleus1.00infobox
DYNC1H1BioGPSMore reference expression data1.00infobox
DYNC1H1Chr.Chromosome 14 (human)1.00infobox
DYNC1H1Chr.Chromosome 12 (mouse)1.00infobox
DYNC1H1DatabasesNCBI: entry; OMA: entry1.00infobox
DYNC1H1End102,056,443 bp1.00infobox
DYNC1H1End110,633,379 bp1.00infobox
DYNC1H1EnsemblENSG000001971021.00infobox

Related concept clusters Related term clusters

The concept neighborhoods around DYNC1H1 bring nearby vocabulary together. In this analysis, examples include Gene, External and Location. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • DYNC1H1
    • Gene
    • External
    • Location
    • Human
    • Protein
    • Dynein
    • Bp
    • Chr
    • Chromosome
    • Dync1h1-related
    • Heavy
    • Disorders
  • dync1h1
    • Gene
    • External
    • Location
    • Human
    • Protein
    • Dynein
    • Bp
    • Chr
    • Chromosome
    • Dync1h1-related
    • Heavy
    • Disorders
  • gene
    • Location
    • Human
    • Bp
    • Chr
    • Chromosome
    • External
    • Mouse
    • Large
    • Band
    • Protein
    • Heavy
    • 14q32
  • dynein
    • Heavy
    • Protein
    • Cell
    • Motor
    • Transport
    • Dync1h1
    • Along
    • Atp
    • Axon
    • Binds
    • Body
    • Cargoes
  • motor protein
    • Protein
    • Large
    • Transport
    • Along
    • Atp
    • Axon
    • External
    • Mouse
    • Q14204
    • Retrograde
    • Uniprot
    • Via
  • protein
    • Large
    • Transport
    • Along
    • Atp
    • Axon
    • External
    • Mouse
    • Q14204
    • Retrograde
    • Uniprot
    • Via
    • Location
  • protein complex
    • Large
    • Transport
    • Along
    • Atp
    • Axon
    • External
    • Mouse
    • Q14204
    • Retrograde
    • Uniprot
    • Via
    • Location
  • axonal transport
    • Q14204
    • Retrograde
    • Uniprot
    • Via

Connections between topic areas Semantic bridges

For DYNC1H1, one of the stronger structural bridges in this analysis connects DYNC1H1 with Clinical relevance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
DYNC1H1 — Clinical relevance · splits 11 ⟂ 6
DYNC1H1 — Overview · splits 12 ⟂ 5
DYNC1H1 — Interactions · splits 12 ⟂ 5

Map overview Semantic statistics

DYNC1H1

Nodes17
Edges16
Triples133
Avg. degree1.88
Density0.117647
Components1

Source & methodology

TTTA analyzes the structure around DYNC1H1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Clinical relevance, Interactions & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — DYNC1H1 · EN edition · Analysis: TopicsToTalkAbout

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