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Cytoplasmic dynein 1 heavy chain 1 is a protein that in humans is encoded by the DYNC1H1 gene. Dynein is a molecular motor protein that is responsible for the transport of numerous cellular cargoes to minus ends of microtubules, which are typically found in the center of a cell, or the cell body of neurons. It is located on the 14th chromosome at…
The analysis highlights Clinical relevance, Interactions and Overview as prominent areas in the source structure around DYNC1H1.
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The extracted context around DYNC1H1 shows recurring relationship patterns in the source. For example, DYNC1H1 → antigen processing and presentation of exogenous peptide antigen via MHC class II, ATP binding, ATPase activity, axon cytoplasm, azurophil granule lumen, cell cortex, cell cycle, cell division, centrosome, ciliary basal body-plasma membrane docking, cytoplasm, cytoplasmic dynein complex, cytoplasmic microtubule, cytoplasmic microtubule organization, cytoskeletal motor activity, cytoskeleton, cytosol, dynein complex, dynein intermediate chain binding, dynein light chain binding Another extracted example is DYNC1H1 → Brodmann area 9, C1 segment, CA3 field, central gray substance of midbrain, dentate gyrus of hippocampal formation granule cell, entorhinal cortex, external carotid artery, facial motor nucleus, ganglionic eminence, lateral nuclear group of thalamus, perirhinal cortex, postcentral gyrus, prefrontal cortex, primary visual cortex, right frontal lobe, right hemisphere of cerebellum, stromal cell of endometrium, superior frontal gyrus, ventricular zone. Use these groups to spot repeated connection types before inspecting the individual relationships.
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dynein gene bp cytoplasmic chain chromosome heavy chr human band protein disorders 14 cell dync1h1-related transport external motor location symptoms
TTTA extracted 133 structured relationships around DYNC1H1. Examples in this analysis include DYNC1H1 → Aliases → DYNC1H1, DHC1, DHC1a, DNCH1, DNCL, DNECL, DYHC, Dnchc1, HL-3, SMALED1, p22, CMT2O, dynein cytoplasmic 1 heavy chain 1 and DYNC1H1 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2BOR, 2BOT. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| DYNC1H1 | Aliases | DYNC1H1, DHC1, DHC1a, DNCH1, DNCL, DNECL, DYHC, Dnchc1, HL-3, SMALED1, p22, CMT2O, dynein cytoplasmic 1 heavy chain 1 | 1.00 | infobox |
| DYNC1H1 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2BOR, 2BOT | 1.00 | infobox |
| DYNC1H1 | Band | 14q32.31 | 1.00 | infobox |
| DYNC1H1 | Band | 12 F1|12 60.7 cM | 1.00 | infobox |
| DYNC1H1 | Bgee | ganglionic eminence | 1.00 | infobox |
| DYNC1H1 | Bgee | ventricular zone | 1.00 | infobox |
| DYNC1H1 | Bgee | prefrontal cortex | 1.00 | infobox |
| DYNC1H1 | Bgee | stromal cell of endometrium | 1.00 | infobox |
| DYNC1H1 | Bgee | right frontal lobe | 1.00 | infobox |
| DYNC1H1 | Bgee | right hemisphere of cerebellum | 1.00 | infobox |
| DYNC1H1 | Bgee | Brodmann area 9 | 1.00 | infobox |
| DYNC1H1 | Bgee | postcentral gyrus | 1.00 | infobox |
| DYNC1H1 | Bgee | lateral nuclear group of thalamus | 1.00 | infobox |
| DYNC1H1 | Bgee | C1 segment | 1.00 | infobox |
| DYNC1H1 | Bgee | dentate gyrus of hippocampal formation granule cell | 1.00 | infobox |
| DYNC1H1 | Bgee | primary visual cortex | 1.00 | infobox |
| DYNC1H1 | Bgee | CA3 field | 1.00 | infobox |
| DYNC1H1 | Bgee | entorhinal cortex | 1.00 | infobox |
| DYNC1H1 | Bgee | superior frontal gyrus | 1.00 | infobox |
| DYNC1H1 | Bgee | perirhinal cortex | 1.00 | infobox |
| DYNC1H1 | Bgee | external carotid artery | 1.00 | infobox |
| DYNC1H1 | Bgee | central gray substance of midbrain | 1.00 | infobox |
| DYNC1H1 | Bgee | facial motor nucleus | 1.00 | infobox |
| DYNC1H1 | BioGPS | More reference expression data | 1.00 | infobox |
| DYNC1H1 | Chr. | Chromosome 14 (human) | 1.00 | infobox |
| DYNC1H1 | Chr. | Chromosome 12 (mouse) | 1.00 | infobox |
| DYNC1H1 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| DYNC1H1 | End | 102,056,443 bp | 1.00 | infobox |
| DYNC1H1 | End | 110,633,379 bp | 1.00 | infobox |
| DYNC1H1 | Ensembl | ENSG00000197102 | 1.00 | infobox |
The concept neighborhoods around DYNC1H1 bring nearby vocabulary together. In this analysis, examples include Gene, External and Location. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For DYNC1H1, one of the stronger structural bridges in this analysis connects DYNC1H1 with Clinical relevance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around DYNC1H1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Clinical relevance, Interactions & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — DYNC1H1 · EN edition · Analysis: TopicsToTalkAbout