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DJ-1: Art, Function & Structure

DJ1, also known as Parkinson disease protein 7, is a protein which in humans is encoded by the PARK7 gene. Its weak glyoxalase activity has been verified by many labs, however the reported protein deglycase activity is likely to be an artifact stemming from DJ-1's ability to destroy free methylglyoxal.

Language: English [EN]
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DJ-1 topic overview

The analysis highlights Art, Function and Structure as prominent areas in the source structure around DJ-1.

Related topics
37
Source areas
4
Connected nodes
41
Extracted relationships
240
Concept neighborhoods
17
Bridge connections
41

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 21 topics
Structure · 10 topics
Interactions · 4 topics
Overview · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3.5.1.124
Aliases
PARK7, DJ-1, DJ1, HEL-S-67p, Parkinsonism associated deglycase, GATD2
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1J42, 1P5F, 1PDV, 1PDW, 1PE0, 1Q2U, 1SOA, 1UCF, 2OR3, 2R1T, 2R1U, 2R1V, 2RK3, 2RK4, 2RK6, 3B36, 3B38, 3B3A,…
Band
1p36.23 · 4|4 E2
Bgee
tibia · deltoid muscle · endothelial cell · Epithelium of choroid plexus · dorsal motor nucleus of vagus nerve
BioGPS
More reference expression data

Suggested research paths

A focused starting point derived from the topic graph, ranked independently of the source article order.

Start with these areas

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Function

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How DJ-1 connects Entity context

The extracted context around DJ-1 shows recurring relationship patterns in the source. For example, DJ-1 → activation of protein kinase B activity, adult locomotory behavior, androgen receptor binding, autophagy, axon, cadherin binding, cell body, cellular oxidant detoxification, cellular response to DNA damage stimulus, cellular response to glyoxal, cellular response to hydrogen peroxide, cellular response to oxidative stress, cellular response to reactive oxygen species, chromatin, copper ion binding, cupric ion binding, cuprous ion binding, cytokine binding, cytoplasm, cytosol Another extracted example is DJ-1 → deltoid muscle, dorsal motor nucleus of vagus nerve, endothelial cell, Epithelium of choroid plexus, extensor digitorum longus muscle, facial motor nucleus, gastrocnemius muscle, islet of Langerhans, medial head of gastrocnemius muscle, Paneth cell, retinal pigment epithelium, right ventricle, Skeletal muscle tissue of biceps brachii, temporal muscle, tibia, tibialis anterior muscle, triceps brachii muscle, vastus lateralis muscle. Use these groups to spot repeated connection types before inspecting the individual relationships.

DJ-1

Top relations

Gene ontology · 150
DJ-1 → activation of protein kinase B activity, adult locomotory behavior, androgen receptor binding, autophagy, axon, cadherin binding, cell body, cellular oxidant detoxification, cellular response to DNA damage stimulus, cellular response to glyoxal, cellular response to hydrogen peroxide, cellular response to oxidative stress, cellular response to reactive oxygen species, chromatin, copper ion binding, cupric ion binding, cuprous ion binding, cytokine binding, cytoplasm, cytosol
Bgee · 18
DJ-1 → deltoid muscle, dorsal motor nucleus of vagus nerve, endothelial cell, Epithelium of choroid plexus, extensor digitorum longus muscle, facial motor nucleus, gastrocnemius muscle, islet of Langerhans, medial head of gastrocnemius muscle, Paneth cell, retinal pigment epithelium, right ventricle, Skeletal muscle tissue of biceps brachii, temporal muscle, tibia, tibialis anterior muscle, triceps brachii muscle, vastus lateralis muscle
RNA expression pattern · 18
DJ-1 → deltoid muscle, dorsal motor nucleus of vagus nerve, endothelial cell, Epithelium of choroid plexus, extensor digitorum longus muscle, facial motor nucleus, gastrocnemius muscle, islet of Langerhans, medial head of gastrocnemius muscle, Paneth cell, retinal pigment epithelium, right ventricle, Skeletal muscle tissue of biceps brachii, temporal muscle, tibia, tibialis anterior muscle, triceps brachii muscle, vastus lateralis muscle
related to External links · 9
DJ-1 → Medicine, Overview, PDB, PDBe-KB, Protein/nucleic, Q99497, This, UniProt, United States National Library
related to Protein · 8
DJ-1 → Archaea, C56, Escherichia, Hsp31, It, The, YajL, YhbO
related to Function · 5
DJ-1 → Accordingly, Catalytic, In, This, Under
related to DNA repair · 4
DJ-1 → DNA, Evidence, Parkinson's, Recently
related to Gene · 3
DJ-1 → C56, PARK7, The
Band · 2
DJ-1 → 1p36.23, 4|4 E2
Chr. · 2
DJ-1 → Chromosome 1 (human), Chromosome 4 (mouse)

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

protein gene park7 human dna bp band chr repair disease activity chromosome methylglyoxal deglycase stress parkinson's also oxidative damage location

DJ-1 relationships Subject–Predicate–Object triples

TTTA extracted 240 structured relationships around DJ-1. Examples in this analysis include DJ-1 → 3.5.1.124 → ↗ and DJ-1 → Aliases → PARK7, DJ-1, DJ1, HEL-S-67p, Parkinsonism associated deglycase, GATD2. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
DJ-13.5.1.1241.00infobox
DJ-1AliasesPARK7, DJ-1, DJ1, HEL-S-67p, Parkinsonism associated deglycase, GATD21.00infobox
DJ-1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1J42, 1P5F, 1PDV, 1PDW, 1PE0, 1Q2U, 1SOA, 1UCF, 2OR3, 2R1T, 2R1U, 2R1V, 2RK3, 2RK4, 2RK6, 3B36, 3B38, 3B3A,…1.00infobox
DJ-1Band1p36.231.00infobox
DJ-1Band4|4 E21.00infobox
DJ-1Bgeetibia1.00infobox
DJ-1Bgeedeltoid muscle1.00infobox
DJ-1Bgeeendothelial cell1.00infobox
DJ-1BgeeEpithelium of choroid plexus1.00infobox
DJ-1Bgeedorsal motor nucleus of vagus nerve1.00infobox
DJ-1Bgeetibialis anterior muscle1.00infobox
DJ-1BgeeSkeletal muscle tissue of biceps brachii1.00infobox
DJ-1Bgeeislet of Langerhans1.00infobox
DJ-1Bgeevastus lateralis muscle1.00infobox
DJ-1Bgeeright ventricle1.00infobox
DJ-1Bgeetriceps brachii muscle1.00infobox
DJ-1Bgeegastrocnemius muscle1.00infobox
DJ-1Bgeemedial head of gastrocnemius muscle1.00infobox
DJ-1Bgeefacial motor nucleus1.00infobox
DJ-1Bgeeretinal pigment epithelium1.00infobox
DJ-1BgeePaneth cell1.00infobox
DJ-1Bgeetemporal muscle1.00infobox
DJ-1Bgeeextensor digitorum longus muscle1.00infobox
DJ-1BioGPSMore reference expression data1.00infobox
DJ-1Chr.Chromosome 1 (human)1.00infobox
DJ-1Chr.Chromosome 4 (mouse)1.00infobox
DJ-1DatabasesNCBI: entry; OMA: entry1.00infobox
DJ-1End7,985,505 bp1.00infobox
DJ-1End150,998,894 bp1.00infobox
DJ-1EnsemblENSG000001162881.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around DJ-1 bring nearby vocabulary together. In this analysis, examples include Protein, Stress and Repair. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • DJ-1
    • Protein
    • Stress
    • Repair
    • Dna
    • Oxidative
    • Human
    • Park7
    • Chaperone
    • Guanine
    • Damage
    • Methylglyoxal
    • Shown
  • dj-1
    • Protein
    • Stress
    • Repair
    • Dna
    • Oxidative
    • Human
    • Park7
    • Chaperone
    • Guanine
    • Damage
    • Methylglyoxal
    • Shown
  • protein
    • Dj-1
    • Human
    • Damage
    • Shown
    • Repair
    • Dna
    • Function
    • Pdb
    • Q99497
    • Uniprot
    • Chaperone
    • End
  • gene
    • Chromosome
    • Location
    • Human
    • Park7
    • Band
    • Bp
    • Chr
    • Function
    • Known
    • Mouse
    • End
    • Deglycase
  • methylglyoxal
    • Guanine
    • Repair
    • Park7
    • Function
    • Mouse
    • Peptidase
    • Q99497
    • Uniprot
    • Chaperone
    • End
    • Glycated
    • Location
  • dna
    • Repair
    • Damage
    • Function
    • Park7
    • End
    • Glycated
    • Guanine
    • Location
    • Dj-1
    • Bp
    • Chr
    • Chromosome
  • dna damage
    • Repair
    • End
    • Damage
    • Dna
    • Function
    • Park7
    • Glycated
    • Guanine
    • Location
    • Dj-1
    • Protein
    • Bp
  • repair of dna double-strand breaks
    • Repair
    • Damage
    • Function
    • Glycated
    • Park7
    • End
    • Guanine
    • Location
    • Dj-1
    • Bp
    • Chr
    • Chromosome

Connections between topic areas Semantic bridges

For DJ-1, one of the stronger structural bridges in this analysis connects DJ-1 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
DJ-1Function · splits 20 ⟂ 22
DJ-1Structure · splits 31 ⟂ 11
DJ-1Interactions · splits 37 ⟂ 5
DJ-1Overview · splits 39 ⟂ 3

Map overview Semantic statistics

DJ-1

Nodes42
Edges41
Triples240
Avg. degree1.95
Density0.047619
Components1

Source & methodology

TTTA analyzes the structure around DJ-1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Art, Function & Structure, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — DJ-1 · EN edition · Analysis: TopicsToTalkAbout

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