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DJ-1

DJ1, also known as Parkinson disease protein 7, is a protein which in humans is encoded by the PARK7 gene. Its weak glyoxalase activity has been verified by many labs, however the reported protein deglycase activity is likely to be an artifact stemming from DJ-1's ability to destroy free methylglyoxal.

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3.5.1.124
↗
Aliases
PARK7, DJ-1, DJ1, HEL-S-67p, Parkinsonism associated deglycase, GATD2
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1J42, 1P5F, 1PDV, 1PDW, 1PE0, 1Q2U, 1SOA, 1UCF, 2OR3, 2R1T, 2R1U, 2R1V, 2RK3, 2RK4, 2RK6, 3B36, 3B38, 3B3A,…
Band
1p36.23 · 4|4 E2
Bgee
tibia · deltoid muscle · endothelial cell · Epithelium of choroid plexus · dorsal motor nucleus of vagus nerve
BioGPS
More reference expression data

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DJ-1

Nodes42
Edges41
Triples240
Avg. degree1.95
Density0.047619
Components1

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DJ-1

Top relations

Gene ontology · 150
DJ-1 → activation of protein kinase B activity, adult locomotory behavior, androgen receptor binding, autophagy, axon, cadherin binding, cell body, cellular oxidant detoxification, cellular response to DNA damage stimulus, cellular response to glyoxal, cellular response to hydrogen peroxide, cellular response to oxidative stress, cellular response to reactive oxygen species, chromatin, copper ion binding, cupric ion binding, cuprous ion binding, cytokine binding, cytoplasm, cytosol
Bgee · 18
DJ-1 → deltoid muscle, dorsal motor nucleus of vagus nerve, endothelial cell, Epithelium of choroid plexus, extensor digitorum longus muscle, facial motor nucleus, gastrocnemius muscle, islet of Langerhans, medial head of gastrocnemius muscle, Paneth cell, retinal pigment epithelium, right ventricle, Skeletal muscle tissue of biceps brachii, temporal muscle, tibia, tibialis anterior muscle, triceps brachii muscle, vastus lateralis muscle
RNA expression pattern · 18
DJ-1 → deltoid muscle, dorsal motor nucleus of vagus nerve, endothelial cell, Epithelium of choroid plexus, extensor digitorum longus muscle, facial motor nucleus, gastrocnemius muscle, islet of Langerhans, medial head of gastrocnemius muscle, Paneth cell, retinal pigment epithelium, right ventricle, Skeletal muscle tissue of biceps brachii, temporal muscle, tibia, tibialis anterior muscle, triceps brachii muscle, vastus lateralis muscle
related to External links · 9
DJ-1 → Medicine, Overview, PDB, PDBe-KB, Protein/nucleic, Q99497, This, UniProt, United States National Library
related to Protein · 8
DJ-1 → Archaea, C56, Escherichia, Hsp31, It, The, YajL, YhbO
related to Function · 5
DJ-1 → Accordingly, Catalytic, In, This, Under
related to DNA repair · 4
DJ-1 → DNA, Evidence, Parkinson's, Recently
related to Gene · 3
DJ-1 → C56, PARK7, The
Band · 2
DJ-1 → 1p36.23, 4|4 E2
Chr. · 2
DJ-1 → Chromosome 1 (human), Chromosome 4 (mouse)

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Important terminology

protein gene park7 human dna bp band chr repair disease activity chromosome methylglyoxal deglycase stress parkinson's also oxidative damage location

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
DJ-13.5.1.124↗1.00infobox
DJ-1AliasesPARK7, DJ-1, DJ1, HEL-S-67p, Parkinsonism associated deglycase, GATD21.00infobox
DJ-1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1J42, 1P5F, 1PDV, 1PDW, 1PE0, 1Q2U, 1SOA, 1UCF, 2OR3, 2R1T, 2R1U, 2R1V, 2RK3, 2RK4, 2RK6, 3B36, 3B38, 3B3A,…1.00infobox
DJ-1Band1p36.231.00infobox
DJ-1Band4|4 E21.00infobox
DJ-1Bgeetibia1.00infobox
DJ-1Bgeedeltoid muscle1.00infobox
DJ-1Bgeeendothelial cell1.00infobox
DJ-1BgeeEpithelium of choroid plexus1.00infobox
DJ-1Bgeedorsal motor nucleus of vagus nerve1.00infobox
DJ-1Bgeetibialis anterior muscle1.00infobox
DJ-1BgeeSkeletal muscle tissue of biceps brachii1.00infobox
DJ-1Bgeeislet of Langerhans1.00infobox
DJ-1Bgeevastus lateralis muscle1.00infobox
DJ-1Bgeeright ventricle1.00infobox
DJ-1Bgeetriceps brachii muscle1.00infobox
DJ-1Bgeegastrocnemius muscle1.00infobox
DJ-1Bgeemedial head of gastrocnemius muscle1.00infobox
DJ-1Bgeefacial motor nucleus1.00infobox
DJ-1Bgeeretinal pigment epithelium1.00infobox
DJ-1BgeePaneth cell1.00infobox
DJ-1Bgeetemporal muscle1.00infobox
DJ-1Bgeeextensor digitorum longus muscle1.00infobox
DJ-1BioGPSMore reference expression data1.00infobox
DJ-1Chr.Chromosome 1 (human)1.00infobox
DJ-1Chr.Chromosome 4 (mouse)1.00infobox
DJ-1DatabasesNCBI: entry; OMA: entry1.00infobox
DJ-1End7,985,505 bp1.00infobox
DJ-1End150,998,894 bp1.00infobox
DJ-1EnsemblENSG000001162881.00infobox

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