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Directed differentiation is a bioengineering methodology at the interface of stem cell biology, developmental biology and tissue engineering. It is essentially harnessing the potential of stem cells by constraining their differentiation in vitro toward a specific cell type or tissue of interest. Stem cells are by definition pluripotent, able to…
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cell cells differentiation stem type pluripotent developmental specific directed tissue vitro types source material pscs interest biology direct also lineage
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| Directed differentiation | is a | bioengineering methodology at the interface of stem cell biology | 0.90 | text |
| neurons | instance of | able to differentiate into several cell types | 0.80 | text |
| cardiomyocytes | instance of | able to differentiate into several cell types | 0.80 | text |
| hepatocytes | instance of | able to differentiate into several cell types | 0.80 | text |
| etc | instance of | able to differentiate into several cell types | 0.80 | text |
| growth factors or small molecules | instance of | A limited number of signaling factors | 0.80 | text |
| controlling cell differentiation | instance of | A limited number of signaling factors | 0.80 | text |
| is applied sequentially or in a combinatorial manner | instance of | A limited number of signaling factors | 0.80 | text |
| at varying dosage | instance of | A limited number of signaling factors | 0.80 | text |
| exposure time | instance of | A limited number of signaling factors | 0.80 | text |
| fibroblasts | instance of | or either differentiated cell type | 0.80 | text |
| embryonic development of human | instance of | that would have been otherwise extremely difficult or impossible to study for technical and ethical reasons in vivo | 0.80 | text |
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