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Dactinomycin: History, Applications & Research

Dactinomycin, also known as actinomycin D, is a chemotherapy medication used to treat a number of types of cancer. This includes Wilms tumor, rhabdomyosarcoma, Ewing's sarcoma, trophoblastic neoplasm, testicular cancer, and certain types of ovarian cancer. It is given by injection into a vein.

Language: English [EN]
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Dactinomycin topic overview

The analysis highlights History, Applications and Research as prominent areas in the source structure around Dactinomycin.

Related topics
65
Source areas
7
Connected nodes
72
Extracted relationships
50
Concept neighborhoods
32
Bridge connections
72

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 17 topics
Biosynthesis · 14 topics
Medical use · 10 topics
Side effects · 8 topics
History · 6 topics
Research use · 6 topics
Mechanism · 4 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
L01DA01 (WHO)
CAS Number
50-76-0 Y
ChEBI
CHEBI:27666 Y
ChEMBL
ChEMBL1554 Y

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Medical use

Side effects

Mechanism

History

Research use

Biosynthesis

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Dactinomycin connects Entity context

The extracted context around Dactinomycin shows recurring relationship patterns in the source. For example, Dactinomycin → Archived, Drug Information Portal, July, Medicine, National Library Another extracted example is Dactinomycin → AU: S4 (Prescription only), CA: ℞-only, UK: POM (Prescription only), US: ℞-only. Use these groups to spot repeated connection types before inspecting the individual relationships.

Dactinomycin

Top relations

related to External links · 5
Dactinomycin → Archived, Drug Information Portal, July, Medicine, National Library
Legal status · 4
Dactinomycin → AU: S4 (Prescription only), CA: ℞-only, UK: POM (Prescription only), US: ℞-only
Other names · 4
Dactinomycin → Actinomycin C1, Actinomycin D, Actinomycin IV, Meractinomycin
3D model (JSmol) · 1
Dactinomycin → Interactive image
AHFS/Drugs.com · 1
Dactinomycin → Monograph
ATC code · 1
Dactinomycin → L01DA01 (WHO)
CAS Number · 1
Dactinomycin → 50-76-0 Y
ChEBI · 1
Dactinomycin → CHEBI:27666 Y
ChEMBL · 1
Dactinomycin → ChEMBL1554 Y
ChemSpider · 1
Dactinomycin → 10482167 Y

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

actinomycin side effects use dna used cancer two 4-mha also tumor occurs types include tryptophan pregnancy medical rhabdomyosarcoma extravasation antibiotic

Dactinomycin relationships Subject–Predicate–Object triples

TTTA extracted 50 structured relationships around Dactinomycin. Examples in this analysis include Dactinomycin → 3D model (JSmol) → Interactive image and Dactinomycin → AHFS/Drugs.com → Monograph. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Dactinomycin3D model (JSmol)Interactive image1.00infobox
DactinomycinAHFS/Drugs.comMonograph1.00infobox
DactinomycinATC codeL01DA01 (WHO)1.00infobox
DactinomycinCAS Number50-76-0 Y1.00infobox
DactinomycinChEBICHEBI:27666 Y1.00infobox
DactinomycinChEMBLChEMBL1554 Y1.00infobox
DactinomycinChemSpider10482167 Y1.00infobox
DactinomycinCompTox Dashboard (EPA)DTXSID90200311.00infobox
DactinomycinDrugBankDB00970 N1.00infobox
DactinomycinECHA InfoCard100.000.0581.00infobox
DactinomycinElimination half-life36 hours1.00infobox
DactinomycinExcretionBile1.00infobox
DactinomycinFormulaC62H86N12O161.00infobox
DactinomycinKEGGC06770 N1.00infobox
DactinomycinLegal statusAU: S4 (Prescription only)1.00infobox
DactinomycinLegal statusCA: ℞-only1.00infobox
DactinomycinLegal statusUK: POM (Prescription only)1.00infobox
DactinomycinLegal statusUS: ℞-only1.00infobox
DactinomycinMedlinePlusa6822241.00infobox
DactinomycinMetabolismhepatic1.00infobox
DactinomycinMolar mass1255.438 g·mol−11.00infobox
DactinomycinNIAID ChemDB0098851.00infobox
DactinomycinOther namesActinomycin C11.00infobox
DactinomycinOther namesActinomycin D1.00infobox
DactinomycinOther namesActinomycin IV1.00infobox
DactinomycinOther namesMeractinomycin1.00infobox
DactinomycinPregnancy categoryAU: D1.00infobox
DactinomycinProtein binding5%1.00infobox
DactinomycinPubChem CID4571931.00infobox
DactinomycinRoutes of administrationIV1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Dactinomycin bring nearby vocabulary together. In this analysis, examples include Medical, Number and Use. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • side effects
    • Side
    • Cancers
    • Include
    • Bone
    • Common
    • Ewing's
    • Extravasation
    • Hair
    • Loss
    • Marrow
    • Medical
    • Mouth
  • Dactinomycin
    • Medical
    • Number
    • Use
    • Used
    • Antibiotic
    • Cancer
    • Cancers
    • Ewing's
    • Pregnancy
    • Rhabdomyosarcoma
    • Sarcoma
    • Trophoblastic
  • dactinomycin
    • Medical
    • Number
    • Use
    • Used
    • Antibiotic
    • Cancer
    • Cancers
    • Ewing's
    • Pregnancy
    • Rhabdomyosarcoma
    • Sarcoma
    • Trophoblastic
  • chemotherapy medication
    • Number
    • Used
    • Dactinomycin
    • Cancer
    • Cancers
    • Ewing's
    • Medical
    • Pregnancy
    • Rhabdomyosarcoma
    • Sarcoma
    • Trophoblastic
    • Types
  • chemotherapy regimens
    • Number
    • Used
    • Dactinomycin
    • Cancer
    • Cancers
    • Ewing's
    • Medical
    • Pregnancy
    • Rhabdomyosarcoma
    • Sarcoma
    • Trophoblastic
    • Types
  • ewing's sarcoma
    • Rhabdomyosarcoma
    • Sarcoma
    • Trophoblastic
    • Tumor
    • Cancers
    • Includes
    • Medical
    • Number
    • Pregnancy
    • Types
    • Effects
    • Side
  • bone marrow suppression
    • Bone
    • Common
    • Hair
    • Loss
    • Marrow
    • Mouth
    • Suppression
    • Include
    • Includes
    • Drug
    • Effects
    • Side
  • cancer
    • Types
    • Chemotherapy
    • Ewing's
    • Includes
    • Number
    • Rhabdomyosarcoma
    • Sarcoma
    • Trophoblastic
    • Tumor
    • Used
    • Dactinomycin

Connections between topic areas Semantic bridges

For Dactinomycin, one of the stronger structural bridges in this analysis connects Dactinomycin with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Dactinomycin — Overview · splits 55 ⟂ 18
Dactinomycin — Biosynthesis · splits 58 ⟂ 15
Dactinomycin — Medical use · splits 62 ⟂ 11
Dactinomycin — Side effects · splits 64 ⟂ 9
Dactinomycin — History · splits 66 ⟂ 7
Dactinomycin — Research use · splits 66 ⟂ 7
Dactinomycin — Mechanism · splits 68 ⟂ 5

Map overview Semantic statistics

Dactinomycin

Nodes73
Edges72
Triples50
Avg. degree1.97
Density0.027397
Components1

Source & methodology

TTTA analyzes the structure around Dactinomycin to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Applications & Research, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Dactinomycin · EN edition · Analysis: TopicsToTalkAbout

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