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DACH1: Structure, Disease relevance & Function

Dachshund homolog 1, also known as DACH1, is a protein which in humans is encoded by the DACH1 gene. DACH1 has been shown to interact with Ubc9, Smad4, and NCoR.

Language: English [EN]
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DACH1 topic overview

The analysis highlights Structure, Disease relevance and Function as prominent areas in the source structure around DACH1.

Related topics
35
Source areas
4
Connected nodes
39
Extracted relationships
136
Concept neighborhoods
19
Bridge connections
39

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Structure · 20 topics
Disease relevance · 6 topics
Function · 5 topics
Overview · 4 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
DACH1, DACH, dachshund family transcription factor 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1L8R
Band
13q21.33 · 14 E2.1|14 48.25 cM
Bgee
ventricular zone · endothelial cell · ganglionic eminence · buccal mucosa cell · glomerulus
BioGPS
More reference expression data
Chr.
Chromosome 13 (human) · Chromosome 14 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Function

Disease relevance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How DACH1 connects Entity context

The extracted context around DACH1 shows recurring relationship patterns in the source. For example, DACH1 → cell population proliferation, cytoplasm, development of primary female sexual characteristics, DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, multicellular organism development, negative regulation of cell migration, negative regulation of cell proliferation involved in contact inhibition, negative regulation of DNA biosynthetic process, negative regulation of fibroblast proliferation, negative regulation of transcription by competitive promoter binding, negative regulation of transcription by RNA polymerase II, negative regulation of transcription, DNA-templated, nucleus, protein binding, regulation of nuclear cell cycle DNA replication, regulation of transcription, DNA-templated, respiratory gaseous exchange by respiratory system Another extracted example is DACH1 → buccal mucosa cell, dorsal striatum, endothelial cell, ganglionic eminence, glomerulus, gonad, granulocyte, hair follicle, left lung lobe, lobe of prostate, medullary collecting duct, metanephric glomerulus, metanephros, renal corpuscle, vas deferens, ventricular zone, vestibular membrane of cochlear duct, visceral pleura. Use these groups to spot repeated connection types before inspecting the individual relationships.

DACH1

Top relations

Gene ontology · 28
DACH1 → cell population proliferation, cytoplasm, development of primary female sexual characteristics, DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, multicellular organism development, negative regulation of cell migration, negative regulation of cell proliferation involved in contact inhibition, negative regulation of DNA biosynthetic process, negative regulation of fibroblast proliferation, negative regulation of transcription by competitive promoter binding, negative regulation of transcription by RNA polymerase II, negative regulation of transcription, DNA-templated, nucleus, protein binding, regulation of nuclear cell cycle DNA replication, regulation of transcription, DNA-templated, respiratory gaseous exchange by respiratory system
Bgee · 18
DACH1 → buccal mucosa cell, dorsal striatum, endothelial cell, ganglionic eminence, glomerulus, gonad, granulocyte, hair follicle, left lung lobe, lobe of prostate, medullary collecting duct, metanephric glomerulus, metanephros, renal corpuscle, vas deferens, ventricular zone, vestibular membrane of cochlear duct, visceral pleura
RNA expression pattern · 18
DACH1 → buccal mucosa cell, dorsal striatum, endothelial cell, ganglionic eminence, glomerulus, gonad, granulocyte, hair follicle, left lung lobe, lobe of prostate, medullary collecting duct, metanephric glomerulus, metanephros, renal corpuscle, vas deferens, ventricular zone, vestibular membrane of cochlear duct, visceral pleura
related to Gene structure · 13
DACH1 → Box-N, DACH, DACH1 Box-N, Dachshund, Dachshund Family, DD1, DNA, DNA-binding, Four, It, Multiple, The X-ray, This
related to Nephropathy · 8
DACH1 → BMP4, Double, Functional, It, R684C, Renal, RHD, TGF-β
related to Protein modification · 7
DACH1 → Acetylation, DACH, EMT, HDAC, Phosphorylation, SUMOYlation, YB-1
related to Transcription · 7
DACH1 → CA150, Curiously, EMT, FKHR, Forkhead-like DNA, Jun, Snail1
related to Cancer · 6
DACH1 → Approximately, Cyclin D1, ERa, Normal, Supporting, These
related to Diabetes · 5
DACH1 → DACH1 Is Increased, HDAC4, Hepatocyte, Nuclear Exclusion, Obese
Band · 2
DACH1 → 13q21.33, 14 E2.1|14 48.25 cM

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

gene protein cell human bp transcription binding chr band chromosome 13 cancer expression including breast factor prostate dachshund mrna kidney

DACH1 relationships Subject–Predicate–Object triples

TTTA extracted 136 structured relationships around DACH1. Examples in this analysis include DACH1 → Aliases → DACH1, DACH, dachshund family transcription factor 1 and DACH1 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1L8R. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
DACH1AliasesDACH1, DACH, dachshund family transcription factor 11.00infobox
DACH1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1L8R1.00infobox
DACH1Band13q21.331.00infobox
DACH1Band14 E2.1|14 48.25 cM1.00infobox
DACH1Bgeeventricular zone1.00infobox
DACH1Bgeeendothelial cell1.00infobox
DACH1Bgeeganglionic eminence1.00infobox
DACH1Bgeebuccal mucosa cell1.00infobox
DACH1Bgeeglomerulus1.00infobox
DACH1Bgeehair follicle1.00infobox
DACH1Bgeemetanephros1.00infobox
DACH1Bgeegonad1.00infobox
DACH1Bgeevisceral pleura1.00infobox
DACH1Bgeemetanephric glomerulus1.00infobox
DACH1Bgeerenal corpuscle1.00infobox
DACH1Bgeeleft lung lobe1.00infobox
DACH1Bgeemedullary collecting duct1.00infobox
DACH1Bgeevas deferens1.00infobox
DACH1Bgeegranulocyte1.00infobox
DACH1Bgeedorsal striatum1.00infobox
DACH1Bgeelobe of prostate1.00infobox
DACH1Bgeevestibular membrane of cochlear duct1.00infobox
DACH1BioGPSMore reference expression data1.00infobox
DACH1Chr.Chromosome 13 (human)1.00infobox
DACH1Chr.Chromosome 14 (mouse)1.00infobox
DACH1DatabasesNCBI: entry; OMA: entry1.00infobox
DACH1End71,867,204 bp1.00infobox
DACH1End98,407,201 bp1.00infobox
DACH1EnsemblENSG000002766441.00infobox
DACH1Entrez16021.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around DACH1 bring nearby vocabulary together. In this analysis, examples include Cell, Protein and Binding. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • DACH1
    • Cell
    • Protein
    • Binding
    • Human
    • Gene
    • Nuclear
    • Proliferation
    • Factor
    • Prostate
    • Breast
    • Cancer
    • Expression
  • dach1
    • Cell
    • Protein
    • Binding
    • Human
    • Gene
    • Nuclear
    • Proliferation
    • Factor
    • Prostate
    • Breast
    • Cancer
    • Expression
  • protein
    • Transcription
    • Function
    • Binding
    • Development
    • Lung
    • Prostate
    • Human
    • Cell
    • Dna
    • Location
    • Migration
    • Repressor
  • gene
    • Development
    • Chromosome
    • Factor
    • Transcription
    • Human
    • Location
    • Cell
    • Protein
    • Dach
    • Family
    • Mrna
    • Bp
  • chromosome 13
    • Bp
    • Location
    • Band
    • Human
    • Mouse
    • Function
    • Gene
    • Migration
    • Development
    • Factor
    • Transcription
    • Protein
  • transcription factors
    • Function
    • Development
    • Mrna
    • Protein
    • Factor
    • Gene
    • Binding
    • Location
    • Migration
    • Cell
    • Dach
    • Dachshund
  • cell
    • Factor
    • Development
    • Nuclear
    • Proliferation
    • Expression
    • Transcription
    • Gene
    • Binding
    • Dach1
    • Protein
    • Function
    • Location
  • dna binding proteins
    • Protein
    • Transcription
    • Cell
    • Dna
    • Function
    • Human
    • Mouse
    • Development
    • Mrna
    • Proliferation
    • Location
    • Migration

Connections between topic areas Semantic bridges

For DACH1, one of the stronger structural bridges in this analysis connects DACH1 with Structure. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
DACH1Structure · splits 19 ⟂ 21
DACH1Disease relevance · splits 33 ⟂ 7
DACH1Function · splits 34 ⟂ 6
DACH1Overview · splits 35 ⟂ 5

Map overview Semantic statistics

DACH1

Nodes40
Edges39
Triples136
Avg. degree1.95
Density0.05
Components1

Source & methodology

TTTA analyzes the structure around DACH1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Structure, Disease relevance & Function, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — DACH1 · EN edition · Analysis: TopicsToTalkAbout

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