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Complement component 1r: Clinical significance, Function & Overview

Complement C1r subcomponent (EC 3.4.21.41, activated complement C1r, C overbar 1r esterase, C1r) is a protein involved in the complement system of the innate immune system. In humans, C1r is encoded by the C1R gene.

Language: English [EN]
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Complement component 1r topic overview

The analysis highlights Clinical significance, Function and Overview as prominent areas in the source structure around Complement component 1r.

Related topics
12
Source areas
3
Connected nodes
15
Extracted relationships
81
Concept neighborhoods
11
Bridge connections
15

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 10 topics
Clinical significance · 1 topics
Function · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3.4.21.41
Aliases
C1R, complement C1r, EDSPD1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1APQ, 1GPZ, 1MD7, 1MD8, 2QY0
Band
12p13.31 · 6 F2|6
Bgee
right lobe of liver · right ovary · gallbladder · right coronary artery · gastric mucosa
BioGPS
n/a

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Clinical significance

Function

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Complement component 1r connects Entity context

The extracted context around Complement component 1r shows recurring relationship patterns in the source. For example, Complement component 1r → adrenal gland, canal of the cervix, dentate gyrus of hippocampal formation granule cell, gallbladder, gastric mucosa, islet of Langerhans, left coronary artery, left ovary, left uterine tube, liver, muscle of thigh, ovary, right coronary artery, right lobe of liver, right ovary, skeletal muscle tissue, spleen, urinary bladder, white adipose tissue Another extracted example is Complement component 1r → blood microparticle, calcium ion binding, complement activation, complement activation, classical pathway, extracellular exosome, extracellular region, extracellular space, hydrolase activity, immune response, immune system process, innate immune response, peptidase activity, protein binding, proteolysis, regulation of complement activation, serine-type endopeptidase activity, serine-type peptidase activity, zymogen activation. Use these groups to spot repeated connection types before inspecting the individual relationships.

Complement component 1r

Top relations

Bgee · 19
Complement component 1r → adrenal gland, canal of the cervix, dentate gyrus of hippocampal formation granule cell, gallbladder, gastric mucosa, islet of Langerhans, left coronary artery, left ovary, left uterine tube, liver, muscle of thigh, ovary, right coronary artery, right lobe of liver, right ovary, skeletal muscle tissue, spleen, urinary bladder, white adipose tissue
RNA expression pattern · 19
Complement component 1r → adrenal gland, canal of the cervix, dentate gyrus of hippocampal formation granule cell, gallbladder, gastric mucosa, islet of Langerhans, left coronary artery, left ovary, left uterine tube, liver, muscle of thigh, ovary, right coronary artery, right lobe of liver, right ovary, skeletal muscle tissue, spleen, urinary bladder, white adipose tissue
Gene ontology · 18
Complement component 1r → blood microparticle, calcium ion binding, complement activation, complement activation, classical pathway, extracellular exosome, extracellular region, extracellular space, hydrolase activity, immune response, immune system process, innate immune response, peptidase activity, protein binding, proteolysis, regulation of complement activation, serine-type endopeptidase activity, serine-type peptidase activity, zymogen activation
Band · 2
Complement component 1r → 12p13.31, 6 F2|6
Chr. · 2
Complement component 1r → Chromosome 12 (human), Chromosome 6 (mouse)
End · 2
Complement component 1r → 124,558,130 bp, 7,092,540 bp
3.4.21.41 · 1
Complement component 1r → ↗
Aliases · 1
Complement component 1r → C1R, complement C1r, EDSPD1
Available structures · 1
Complement component 1r → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1APQ, 1GPZ, 1MD7, 1MD8, 2QY0
BioGPS · 1
Complement component 1r → n/a

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

c1r gene bp human complement chr band c1s chromosome 12 location system form protein enzyme mouse 21 41 innate immune

Complement component 1r relationships Subject–Predicate–Object triples

TTTA extracted 81 structured relationships around Complement component 1r. Examples in this analysis include Complement component 1r → 3.4.21.41 → ↗ and Complement component 1r → Aliases → C1R, complement C1r, EDSPD1. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Complement component 1r3.4.21.411.00infobox
Complement component 1rAliasesC1R, complement C1r, EDSPD11.00infobox
Complement component 1rAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1APQ, 1GPZ, 1MD7, 1MD8, 2QY01.00infobox
Complement component 1rBand12p13.311.00infobox
Complement component 1rBand6 F2|61.00infobox
Complement component 1rBgeeright lobe of liver1.00infobox
Complement component 1rBgeeright ovary1.00infobox
Complement component 1rBgeegallbladder1.00infobox
Complement component 1rBgeeright coronary artery1.00infobox
Complement component 1rBgeegastric mucosa1.00infobox
Complement component 1rBgeeleft ovary1.00infobox
Complement component 1rBgeeleft uterine tube1.00infobox
Complement component 1rBgeeleft coronary artery1.00infobox
Complement component 1rBgeeurinary bladder1.00infobox
Complement component 1rBgeecanal of the cervix1.00infobox
Complement component 1rBgeewhite adipose tissue1.00infobox
Complement component 1rBgeeadrenal gland1.00infobox
Complement component 1rBgeemuscle of thigh1.00infobox
Complement component 1rBgeedentate gyrus of hippocampal formation granule cell1.00infobox
Complement component 1rBgeeliver1.00infobox
Complement component 1rBgeeovary1.00infobox
Complement component 1rBgeeskeletal muscle tissue1.00infobox
Complement component 1rBgeespleen1.00infobox
Complement component 1rBgeeislet of Langerhans1.00infobox
Complement component 1rBioGPSn/a1.00infobox
Complement component 1rChr.Chromosome 12 (human)1.00infobox
Complement component 1rChr.Chromosome 6 (mouse)1.00infobox
Complement component 1rDatabasesNCBI: entry; OMA: entry1.00infobox
Complement component 1rEnd7,092,540 bp1.00infobox
Complement component 1rEnd124,558,130 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Complement component 1r bring nearby vocabulary together. In this analysis, examples include System, Activity and Component. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Complement component 1r
    • System
    • Activity
    • Component
    • Function
    • Immune
    • Innate
    • Protein
    • Search
    • End
    • F2
    • Ucsc
    • C1s
  • complement component 1r
    • Activated
    • Ec3
    • Overbar
    • Subcomponent
    • System
    • Immune
    • Innate
    • Protein
    • Activity
    • Component
    • Function
    • Search
  • complement system
    • System
    • Activity
    • Component
    • Function
    • Immune
    • Innate
    • Protein
    • Search
    • C1s
    • Chromosome
    • Location
    • Bp
  • c1s
    • Form
    • Active
    • Component
    • System
    • Complement
    • Proteolytic
    • Activity
    • End
    • Enzyme
    • F2
    • Function
    • Immune
  • innate immune system
    • Immune
    • Innate
    • Protein
    • System
    • Overbar
    • Subcomponent
    • Activity
    • Component
    • End
    • F2
    • Function
    • Mouse
  • protein
    • Immune
    • Innate
    • System
    • Subcomponent
    • Activity
    • Component
    • End
    • F2
    • Function
    • Mouse
    • Search
    • Ucsc
  • function
    • Activity
    • Search
    • Chromosome
    • Location
    • Bp
    • Chr
    • Gene
    • Human
    • End
    • F2
    • Immune
    • Innate
  • gene
    • Location
    • Human
    • End
    • F2
    • Mouse
    • Search
    • Ucsc
    • Band
    • Immune
    • Innate
    • Protein
    • System

Connections between topic areas Semantic bridges

For Complement component 1r, one of the stronger structural bridges in this analysis connects Complement component 1r with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Complement component 1rOverview · splits 5 ⟂ 11

Map overview Semantic statistics

Complement component 1r

Nodes16
Edges15
Triples81
Avg. degree1.88
Density0.125
Components1

Source & methodology

TTTA analyzes the structure around Complement component 1r to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Clinical significance, Function & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Complement component 1r · EN edition · Analysis: TopicsToTalkAbout

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