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Complement component 1r

Complement C1r subcomponent (EC 3.4.21.41, activated complement C1r, C overbar 1r esterase, C1r) is a protein involved in the complement system of the innate immune system. In humans, C1r is encoded by the C1R gene.

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Clinical significance

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Function

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3.4.21.41
Aliases
C1R, complement C1r, EDSPD1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1APQ, 1GPZ, 1MD7, 1MD8, 2QY0
Band
12p13.31 · 6 F2|6
Bgee
right lobe of liver · right ovary · gallbladder · right coronary artery · gastric mucosa
BioGPS
n/a

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Clinical significance

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Map overview Semantic statistics

Complement component 1r

Nodes16
Edges15
Triples81
Avg. degree1.88
Density0.125
Components1

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Complement component 1r

Top relations

Bgee · 19
Complement component 1r → adrenal gland, canal of the cervix, dentate gyrus of hippocampal formation granule cell, gallbladder, gastric mucosa, islet of Langerhans, left coronary artery, left ovary, left uterine tube, liver, muscle of thigh, ovary, right coronary artery, right lobe of liver, right ovary, skeletal muscle tissue, spleen, urinary bladder, white adipose tissue
RNA expression pattern · 19
Complement component 1r → adrenal gland, canal of the cervix, dentate gyrus of hippocampal formation granule cell, gallbladder, gastric mucosa, islet of Langerhans, left coronary artery, left ovary, left uterine tube, liver, muscle of thigh, ovary, right coronary artery, right lobe of liver, right ovary, skeletal muscle tissue, spleen, urinary bladder, white adipose tissue
Gene ontology · 18
Complement component 1r → blood microparticle, calcium ion binding, complement activation, complement activation, classical pathway, extracellular exosome, extracellular region, extracellular space, hydrolase activity, immune response, immune system process, innate immune response, peptidase activity, protein binding, proteolysis, regulation of complement activation, serine-type endopeptidase activity, serine-type peptidase activity, zymogen activation
Band · 2
Complement component 1r → 12p13.31, 6 F2|6
Chr. · 2
Complement component 1r → Chromosome 12 (human), Chromosome 6 (mouse)
End · 2
Complement component 1r → 124,558,130 bp, 7,092,540 bp
3.4.21.41 · 1
Complement component 1r → ↗
Aliases · 1
Complement component 1r → C1R, complement C1r, EDSPD1
Available structures · 1
Complement component 1r → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1APQ, 1GPZ, 1MD7, 1MD8, 2QY0
BioGPS · 1
Complement component 1r → n/a

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Important terminology

c1r gene bp human complement chr band c1s chromosome 12 location system form protein enzyme mouse 21 41 innate immune

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Complement component 1r3.4.21.411.00infobox
Complement component 1rAliasesC1R, complement C1r, EDSPD11.00infobox
Complement component 1rAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1APQ, 1GPZ, 1MD7, 1MD8, 2QY01.00infobox
Complement component 1rBand12p13.311.00infobox
Complement component 1rBand6 F2|61.00infobox
Complement component 1rBgeeright lobe of liver1.00infobox
Complement component 1rBgeeright ovary1.00infobox
Complement component 1rBgeegallbladder1.00infobox
Complement component 1rBgeeright coronary artery1.00infobox
Complement component 1rBgeegastric mucosa1.00infobox
Complement component 1rBgeeleft ovary1.00infobox
Complement component 1rBgeeleft uterine tube1.00infobox
Complement component 1rBgeeleft coronary artery1.00infobox
Complement component 1rBgeeurinary bladder1.00infobox
Complement component 1rBgeecanal of the cervix1.00infobox
Complement component 1rBgeewhite adipose tissue1.00infobox
Complement component 1rBgeeadrenal gland1.00infobox
Complement component 1rBgeemuscle of thigh1.00infobox
Complement component 1rBgeedentate gyrus of hippocampal formation granule cell1.00infobox
Complement component 1rBgeeliver1.00infobox
Complement component 1rBgeeovary1.00infobox
Complement component 1rBgeeskeletal muscle tissue1.00infobox
Complement component 1rBgeespleen1.00infobox
Complement component 1rBgeeislet of Langerhans1.00infobox
Complement component 1rBioGPSn/a1.00infobox
Complement component 1rChr.Chromosome 12 (human)1.00infobox
Complement component 1rChr.Chromosome 6 (mouse)1.00infobox
Complement component 1rDatabasesNCBI: entry; OMA: entry1.00infobox
Complement component 1rEnd7,092,540 bp1.00infobox
Complement component 1rEnd124,558,130 bp1.00infobox

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