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Carboxylesterase 1

Liver carboxylesterase 1 also known as carboxylesterase 1 (CES1, hCE-1 or CES1A1) is an enzyme that in humans is encoded by the CES1 gene. The protein is also historically known as serine esterase 1 (SES1), monocyte esterase and cholesterol ester hydrolase (CEH). Three transcript variants encoding three different isoforms have been found for this gene.…

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3.1.1.1
↗
3.1.1.13
↗
3.1.1.56
↗
Aliases
CES1, ACAT, CE-1, CEH, CES2, HMSE, HMSE1, PCE-1, REH, SES1, TGH, hCE-1, carboxylesterase 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1MX1, 1MX5, 1MX9, 1YA4, 1YA8, 1YAH, 1YAJ, 2DQY, 2DQZ, 2DR0, 2H7C, 2HRQ, 2HRR, 3K9B, 4AB1, 5A7F, 5A7H, 5A7G
Band
16q12.2 · 8|8 C5

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Carboxylesterase 1

Nodes31
Edges30
Triples101
Avg. degree1.94
Density0.064516
Components1

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Carboxylesterase 1

Top relations

Bgee · 19
Carboxylesterase 1 → apex of heart, brown adipose tissue, Descending thoracic aorta, epithelium of colon, gallbladder, lacrimal gland, left lung, muscle layer of sigmoid colon, nasal epithelium, olfactory epithelium, olfactory zone of nasal mucosa, right lobe of liver, right lung, right lung lobe, smooth muscle tissue, superior surface of tongue, tunica adventitia of aorta, upper lobe of left lung, white adipose tissue
RNA expression pattern · 19
Carboxylesterase 1 → apex of heart, brown adipose tissue, Descending thoracic aorta, epithelium of colon, gallbladder, lacrimal gland, left lung, muscle layer of sigmoid colon, nasal epithelium, olfactory epithelium, olfactory zone of nasal mucosa, right lobe of liver, right lung, right lung lobe, smooth muscle tissue, superior surface of tongue, tunica adventitia of aorta, upper lobe of left lung, white adipose tissue
Gene ontology · 18
Carboxylesterase 1 → angiotensin maturation, carboxylic ester hydrolase activity, cholesterol biosynthetic process, cholesterol ester hydrolysis involved in cholesterol transport, cytosol, endoplasmic reticulum, endoplasmic reticulum lumen, epithelial cell differentiation, extracellular space, hydrolase activity, lipid catabolic process, medium-chain fatty acid metabolic process, methyl indole-3-acetate esterase activity, methylumbelliferyl-acetate deacetylase activity, response to toxic substance, sterol esterase activity, triglyceride lipase activity, xenobiotic metabolic process
related to Clinical significance · 8
Carboxylesterase 1 → ACE, B-cell, Carboxylesterase, CES1, Genetic, Hodgkin, Inhibition, The
related to Function · 7
Carboxylesterase 1 → As, Carboxylesterase, II, It, These, They, This
Band · 2
Carboxylesterase 1 → 16q12.2, 8|8 C5
Chr. · 2
Carboxylesterase 1 → Chromosome 16 (human), Chromosome 8 (mouse)
End · 2
Carboxylesterase 1 → 55,833,337 bp, 93,924,466 bp
3.1.1.1 · 1
Carboxylesterase 1 → ↗
3.1.1.13 · 1
Carboxylesterase 1 → ↗

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Important terminology

ces1 gene bp protein chr human band also enzyme carboxylesterase chromosome 16 liver known esterase ester hydrolase cholesterol location drugs

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Carboxylesterase 13.1.1.1↗1.00infobox
Carboxylesterase 13.1.1.13↗1.00infobox
Carboxylesterase 13.1.1.56↗1.00infobox
Carboxylesterase 1AliasesCES1, ACAT, CE-1, CEH, CES2, HMSE, HMSE1, PCE-1, REH, SES1, TGH, hCE-1, carboxylesterase 11.00infobox
Carboxylesterase 1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1MX1, 1MX5, 1MX9, 1YA4, 1YA8, 1YAH, 1YAJ, 2DQY, 2DQZ, 2DR0, 2H7C, 2HRQ, 2HRR, 3K9B, 4AB1, 5A7F, 5A7H, 5A7G1.00infobox
Carboxylesterase 1Band16q12.21.00infobox
Carboxylesterase 1Band8|8 C51.00infobox
Carboxylesterase 1Bgeeright lobe of liver1.00infobox
Carboxylesterase 1Bgeegallbladder1.00infobox
Carboxylesterase 1Bgeeright lung1.00infobox
Carboxylesterase 1Bgeeolfactory zone of nasal mucosa1.00infobox
Carboxylesterase 1Bgeeupper lobe of left lung1.00infobox
Carboxylesterase 1Bgeesmooth muscle tissue1.00infobox
Carboxylesterase 1Bgeeapex of heart1.00infobox
Carboxylesterase 1Bgeemuscle layer of sigmoid colon1.00infobox
Carboxylesterase 1BgeeDescending thoracic aorta1.00infobox
Carboxylesterase 1Bgeeepithelium of colon1.00infobox
Carboxylesterase 1Bgeewhite adipose tissue1.00infobox
Carboxylesterase 1Bgeelacrimal gland1.00infobox
Carboxylesterase 1Bgeeright lung lobe1.00infobox
Carboxylesterase 1Bgeenasal epithelium1.00infobox
Carboxylesterase 1Bgeetunica adventitia of aorta1.00infobox
Carboxylesterase 1Bgeeolfactory epithelium1.00infobox
Carboxylesterase 1Bgeesuperior surface of tongue1.00infobox
Carboxylesterase 1Bgeebrown adipose tissue1.00infobox
Carboxylesterase 1Bgeeleft lung1.00infobox
Carboxylesterase 1BioGPSn/a1.00infobox
Carboxylesterase 1Chr.Chromosome 16 (human)1.00infobox
Carboxylesterase 1Chr.Chromosome 8 (mouse)1.00infobox
Carboxylesterase 1DatabasesNCBI: entry; OMA: entry1.00infobox

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