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Cefoxitin

Cefoxitin is a second-generation cephamycin antibiotic developed by Merck & Co., Inc. from Cephamycin C in the year following its discovery, 1972. It was synthesized in order to create an antibiotic with a broader spectrum. It is often grouped with the second-generation cephalosporins. Cefoxitin requires a prescription and as of 2010 is sold under the…

History & Applications

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Spectrum of bacterial susceptibility

Gram-negativeGram-positiveBacteriaAnaerobesPseudomonas aeruginosa
20 related topics

History and discovery

Cephem
1 related topics

Mechanism

Beta-lactamaseImipenem
2 related topics

Microbiological resistance

MecAMRSA
2 related topics

Key facts & relationships

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
J01DC01 (WHO)
CAS Number
35607-66-0 Y
ChEBI
CHEBI:209807 N
ChEMBL
ChEMBL996 N

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Overview

History and discovery

Mechanism

Microbiological resistance

  • MecA MecA (gene)
  • MRSA Methicillin-resistant Staphylococcus aureus

Spectrum of bacterial susceptibility

Replacement and substitution

Uses in medicine

Side effects

Pharmacodynamic and pharmacokinetic data

Advanced semantic analysis

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Map overview Semantic statistics

Cefoxitin

Nodes47
Edges46
Triples102
Avg. degree1.96
Density0.042553
Components1

How this topic connects Entity context

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Cefoxitin

Top relations

related to Microbiological resistance · 10
Cefoxitin → Another, As, For, In, MRSA, PBP, PBP2a, Staphylococcus, This, This PBP
related to history · 9
Cefoxitin → Cephamycin, Gram, Groups, Lilly, Merck, More, The, This, Yet
related to Pharmacodynamic and pharmacokinetic data · 9
Cefoxitin → French Ministry, GI, Health, However, Hôpitaux, One, Paris, Pharmocokinetic, The
related to Replacement and substitution · 9
Cefoxitin → Due, Fernandes, Funsun, In, Interpretive, Likewise, MRSA, Staphylococcus, United States
related to External links · 6
Cefoxitin → Archived, Drug Information Portal, June, Medicine, National Library, November
related to Spectrum of bacterial susceptibility · 6
Cefoxitin → Cefoxitin's, Enterobacter, It, Major, Pseudomonas, Staphylococci
related to Mechanism · 4
Cefoxitin → By, However, It, PBPs
Legal status · 3
Cefoxitin → AU: S4 (Prescription only), UK: POM (Prescription only), US: ℞-only
related to Contraindications · 3
Cefoxitin → For, However, Patients
related to Minor · 3
Cefoxitin → Minor, Two, Your

Important terminology Word statistics

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Important terminology

bacteria antibiotic spectrum cephamycin bacterial used drug discovery data due antibiotics staphylococcus also sp study may resistance side effects beta-lactamase

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Cefoxitin3D model (JSmol)Interactive image1.00infobox
CefoxitinAHFS/Drugs.comMonograph1.00infobox
CefoxitinATC codeJ01DC01 (WHO)1.00infobox
CefoxitinCAS Number35607-66-0 Y1.00infobox
CefoxitinChEBICHEBI:209807 N1.00infobox
CefoxitinChEMBLChEMBL996 N1.00infobox
CefoxitinChemSpider389981 Y1.00infobox
CefoxitinCompTox Dashboard (EPA)DTXSID10227641.00infobox
CefoxitinDrugBankDB01331 N1.00infobox
CefoxitinECHA InfoCard100.047.8411.00infobox
CefoxitinElimination half-life41-59 min1.00infobox
CefoxitinExcretion85% urine1.00infobox
CefoxitinFormulaC16H17N3O7S21.00infobox
CefoxitinKEGGD02345 N1.00infobox
CefoxitinKEGGas salt: D00913 N1.00infobox
CefoxitinLegal statusAU: S4 (Prescription only)1.00infobox
CefoxitinLegal statusUK: POM (Prescription only)1.00infobox
CefoxitinLegal statusUS: ℞-only1.00infobox
CefoxitinLicense dataUS DailyMed: Cefoxitin1.00infobox
CefoxitinMedlinePlusa6827371.00infobox
CefoxitinMelting point149 to 150 °C (300 to 302 °F) (dec.)1.00infobox
CefoxitinMetabolismminimal1.00infobox
CefoxitinMolar mass427.45 g·mol−11.00infobox
CefoxitinPregnancy categoryAU: B11.00infobox
CefoxitinPubChem CID4411991.00infobox
CefoxitinRoutes of administrationIntravenous1.00infobox
CefoxitinTrade namesMefoxin, Renoxitin, others1.00infobox
CefoxitinUNII6OEV9DX57Y1.00infobox
Cefoxitinis asecond-generation cephamycin antibiotic developed by Merck0.90text
Cefoxitinis abetter substrate than imipenem for beta-lactamases0.90text

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