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Cefoxitin: History & Applications

Cefoxitin is a second-generation cephamycin antibiotic developed by Merck & Co., Inc. from Cephamycin C in the year following its discovery, 1972. It was synthesized in order to create an antibiotic with a broader spectrum. It is often grouped with the second-generation cephalosporins. Cefoxitin requires a prescription and as of 2010 is sold under the…

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Cefoxitin topic overview

The analysis highlights History and Applications as prominent areas in the source structure around Cefoxitin.

Related topics
37
Source areas
9
Connected nodes
46
Extracted relationships
75
Related term clusters
17
Bridge connections
46

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Spectrum of bacterial susceptibility · 20 topics
Overview · 5 topics
Mechanism · 2 topics
Microbiological resistance · 2 topics
Pharmacodynamic and pharmacokinetic data · 2 topics
Side effects · 2 topics
Uses in medicine · 2 topics
History and discovery · 1 topics
Replacement and substitution · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
J01DC01 (WHO)
CAS Number
35607-66-0 Y
ChEBI
CHEBI:209807 N
ChEMBL
ChEMBL996 N

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Explore different angles and find fresh ideas to shape your next piece of content.

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

History and discovery

Mechanism

Microbiological resistance

Spectrum of bacterial susceptibility

Replacement and substitution

Uses in medicine

Side effects

Pharmacodynamic and pharmacokinetic data

For the semantics nerds

You can skip this section if you’re here for content ideas and keyword inspiration.

Advanced semantic analysis

How Cefoxitin connects Entity context

The extracted context around Cefoxitin shows recurring relationship patterns in the source. For example, Cefoxitin → Due, Fernandes, Funsun, Interpretive, Likewise, MRSA, Staphylococcus, United States Another extracted example is Cefoxitin → French Ministry, GI, Health, Hôpitaux, One, Paris, Pharmocokinetic. Use these groups to spot repeated connection types before inspecting the individual relationships.

Cefoxitin

Top relations

related to Replacement and substitution · 8
Cefoxitin → Due, Fernandes, Funsun, Interpretive, Likewise, MRSA, Staphylococcus, United States
related to Pharmacodynamic and pharmacokinetic data · 7
Cefoxitin → French Ministry, GI, Health, Hôpitaux, One, Paris, Pharmocokinetic
related to history · 6
Cefoxitin → Cephamycin, Gram, Groups, Lilly, Merck, Yet
related to Microbiological resistance · 6
Cefoxitin → Another, MRSA, PBP, PBP2a, Staphylococcus, This PBP
related to Spectrum of bacterial susceptibility · 5
Cefoxitin → Cefoxitin's, Enterobacter, Major, Pseudomonas, Staphylococci
Legal status · 3
Cefoxitin → AU: S4 (Prescription only), UK: POM (Prescription only), US: ℞-only
KEGG · 2
Cefoxitin → as salt: D00913 N, D02345 N
is a · 2
Cefoxitin → better substrate than imipenem for beta-lactamases, second-generation cephamycin antibiotic developed by Merck
has effect · 2
Cefoxitin → Common, Side
related to Major or Severe · 2
Cefoxitin → Aside, Individuals

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

bacteria antibiotic spectrum cephamycin bacterial used drug discovery data due antibiotics staphylococcus also sp study may resistance side effects beta-lactamase

Cefoxitin relationships Subject–Predicate–Object triples

TTTA extracted 75 structured relationships around Cefoxitin. Examples in this analysis include Cefoxitin → 3D model (JSmol) → Interactive image and Cefoxitin → AHFS/Drugs.com → Monograph. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Cefoxitin3D model (JSmol)Interactive image1.00infobox
CefoxitinAHFS/Drugs.comMonograph1.00infobox
CefoxitinATC codeJ01DC01 (WHO)1.00infobox
CefoxitinCAS Number35607-66-0 Y1.00infobox
CefoxitinChEBICHEBI:209807 N1.00infobox
CefoxitinChEMBLChEMBL996 N1.00infobox
CefoxitinChemSpider389981 Y1.00infobox
CefoxitinCompTox Dashboard (EPA)DTXSID10227641.00infobox
CefoxitinDrugBankDB01331 N1.00infobox
CefoxitinECHA InfoCard100.047.8411.00infobox
CefoxitinElimination half-life41-59 min1.00infobox
CefoxitinExcretion85% urine1.00infobox
CefoxitinFormulaC16H17N3O7S21.00infobox
CefoxitinKEGGD02345 N1.00infobox
CefoxitinKEGGas salt: D00913 N1.00infobox
CefoxitinLegal statusAU: S4 (Prescription only)1.00infobox
CefoxitinLegal statusUK: POM (Prescription only)1.00infobox
CefoxitinLegal statusUS: ℞-only1.00infobox
CefoxitinLicense dataUS DailyMed: Cefoxitin1.00infobox
CefoxitinMedlinePlusa6827371.00infobox
CefoxitinMelting point149 to 150 °C (300 to 302 °F) (dec.)1.00infobox
CefoxitinMetabolismminimal1.00infobox
CefoxitinMolar mass427.45 g·mol−11.00infobox
CefoxitinPregnancy categoryAU: B11.00infobox
CefoxitinPubChem CID4411991.00infobox
CefoxitinRoutes of administrationIntravenous1.00infobox
CefoxitinTrade namesMefoxin, Renoxitin, others1.00infobox
CefoxitinUNII6OEV9DX57Y1.00infobox
Cefoxitinis asecond-generation cephamycin antibiotic developed by Merck0.90text
Cefoxitinis abetter substrate than imipenem for beta-lactamases0.90text

Related concept clusters Related term clusters

The concept neighborhoods around Cefoxitin bring nearby vocabulary together. In this analysis, examples include Bacteria, Bacterial and Staphylococcus. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Cefoxitin
    • Bacteria
    • Bacterial
    • Staphylococcus
    • Aureus
    • Cephamycin
    • Resistance
    • Resistant
    • Also
    • Antibiotic
    • Beta-lactamases
    • Disk
    • Major
  • cefoxitin
    • Bacteria
    • Bacterial
    • Staphylococcus
    • Aureus
    • Cephamycin
    • Resistance
    • Resistant
    • Also
    • Antibiotic
    • Beta-lactamases
    • Disk
    • Major
  • bacteria
    • Resistance
    • Spectrum
    • Cefoxitin
    • Beta-lactamases
    • Include
    • Major
    • Cephamycin
    • Resistant
    • Staphylococcus
    • Bacterial
    • Pharmacodynamic
    • Beta-lactamase
  • spectrum of bacterial susceptibility
    • Given
    • Major
    • Susceptible
    • Resistance
    • Due
    • Spectrum
    • Staphylococcus
    • Cefoxitin
    • Bacteria
    • Pharmacodynamic
    • Treatment
    • Beta-lactamase
  • antibiotic
    • Spectrum
    • Given
    • Discovery
    • Also
    • Bacterial
    • Cefoxitin
    • Beta-lactamase
    • Binding
    • Disease
    • Disk
    • Methicillin
    • Part
  • staphylococcus aureus
    • Staphylococcus
    • Susceptible
    • Disk
    • Include
    • Major
    • Resistant
    • Sp
    • Gene
    • Cefoxitin
    • Disease
    • Given
    • Resistance
  • cephamycin
    • Discovery
    • Beta-lactamases
    • Resistant
    • Bacteria
    • Pharmacodynamic
    • Data
    • Major
    • Part
    • Effects
    • Resistance
    • Side
    • Drug
  • history and discovery
    • Pharmacodynamic
    • Data
    • Major
    • Part
    • Effects
    • Resistance
    • Side
    • Drug
    • Due
    • Spectrum
    • Bacterial
    • Bacteria

Connections between topic areas Semantic bridges

For Cefoxitin, one of the stronger structural bridges in this analysis connects Cefoxitin with Spectrum of bacterial susceptibility. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Cefoxitin — Spectrum of bacterial susceptibility · splits 26 ⟂ 21
Cefoxitin — Overview · splits 41 ⟂ 6
Cefoxitin — Mechanism · splits 44 ⟂ 3
Cefoxitin — Microbiological resistance · splits 44 ⟂ 3
Cefoxitin — Uses in medicine · splits 44 ⟂ 3
Cefoxitin — Side effects · splits 44 ⟂ 3
Cefoxitin — Pharmacodynamic and pharmacokinetic data · splits 44 ⟂ 3

Map overview Semantic statistics

Cefoxitin

Nodes47
Edges46
Triples75
Avg. degree1.96
Density0.042553
Components1

Source & methodology

TTTA analyzes the structure around Cefoxitin to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History & Applications, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Cefoxitin · EN edition · Analysis: TopicsToTalkAbout

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