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CD48: Function, Structure & Overview

CD48 antigen (cluster of differentiation 48) also known as B-lymphocyte activation marker (BLAST-1) or signaling lymphocytic activation molecule 2 (SLAMF2) is a protein that in humans is encoded by the CD48 gene.

Language: English [EN]
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CD48 topic overview

The analysis highlights Function, Structure and Overview as prominent areas in the source structure around CD48.

Related topics
36
Source areas
5
Connected nodes
41
Extracted relationships
111
Concept neighborhoods
23
Bridge connections
41

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 15 topics
Function · 9 topics
Structure · 7 topics
Interactions · 4 topics
Clinical significance · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
CD48, BCM1, BLAST, BLAST1, MEM-102, SLAMF2, hmCD48 molecule
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2EDO
Band
1q23.3 · 1 H3|1 79.54 cM
Bgee
white blood cell · mononuclear cell · monocyte · granulocyte · blood
BioGPS
More reference expression data
Chr.
Chromosome 1 (human) · Chromosome 1 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Interactions

Function

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How CD48 connects Entity context

The extracted context around CD48 shows recurring relationship patterns in the source. For example, CD48 → appendix, blood, bone marrow cell, calvaria, epithelium of colon, granulocyte, lymph node, mesenteric lymph nodes, monocyte, mononuclear cell, pharynx, spleen, stroma of bone marrow, subcutaneous adipose tissue, thymus, white adipose tissue, white blood cell Another extracted example is CD48 → anchored component of membrane, antigen binding, defense response, extracellular exosome, integral component of plasma membrane, intrinsic component of plasma membrane, leukocyte migration, membrane, membrane raft, plasma membrane, protein binding, regulation of adaptive immune response, signaling receptor activity. Use these groups to spot repeated connection types before inspecting the individual relationships.

CD48

Top relations

Bgee · 17
CD48 → appendix, blood, bone marrow cell, calvaria, epithelium of colon, granulocyte, lymph node, mesenteric lymph nodes, monocyte, mononuclear cell, pharynx, spleen, stroma of bone marrow, subcutaneous adipose tissue, thymus, white adipose tissue, white blood cell
RNA expression pattern · 17
CD48 → appendix, blood, bone marrow cell, calvaria, epithelium of colon, granulocyte, lymph node, mesenteric lymph nodes, monocyte, mononuclear cell, pharynx, spleen, stroma of bone marrow, subcutaneous adipose tissue, thymus, white adipose tissue, white blood cell
Gene ontology · 13
CD48 → anchored component of membrane, antigen binding, defense response, extracellular exosome, integral component of plasma membrane, intrinsic component of plasma membrane, leukocyte migration, membrane, membrane raft, plasma membrane, protein binding, regulation of adaptive immune response, signaling receptor activity
related to External links · 8
CD48 → Human CD48, Medicine, Medicine Medical Subject Headings, MeSH, National Library, This, UCSC Genome Browser, United States National Library
related to Structure · 8
CD48 → Approximately, C-terminal, C2, GPI, It, The, The CD48, The GPI
related to T-cell activation · 8
CD48 → CD2, CD28, CD80, GPI, ICAM-1, LFA-1, MHC, TCR
related to Interactions · 7
CD48 → CD2, CD244, IgSF, It, NK, SLAM, The
related to Cell distribution · 6
CD48 → GPI, GPI-AP, It, Like, NK, PBL
Band · 2
CD48 → 1 H3|1 79.54 cM, 1q23.3
Chr. · 2
CD48 → Chromosome 1 (human), Chromosome 1 (mouse)

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

human bp gene cd2 activation gpi chr band cell chromosome differentiation protein antigen cells also location signaling found surface cd244

CD48 relationships Subject–Predicate–Object triples

TTTA extracted 111 structured relationships around CD48. Examples in this analysis include CD48 → Aliases → CD48, BCM1, BLAST, BLAST1, MEM-102, SLAMF2, hmCD48 molecule and CD48 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2EDO. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
CD48AliasesCD48, BCM1, BLAST, BLAST1, MEM-102, SLAMF2, hmCD48 molecule1.00infobox
CD48Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2EDO1.00infobox
CD48Band1q23.31.00infobox
CD48Band1 H3|1 79.54 cM1.00infobox
CD48Bgeewhite blood cell1.00infobox
CD48Bgeemononuclear cell1.00infobox
CD48Bgeemonocyte1.00infobox
CD48Bgeegranulocyte1.00infobox
CD48Bgeeblood1.00infobox
CD48Bgeebone marrow cell1.00infobox
CD48Bgeeappendix1.00infobox
CD48Bgeespleen1.00infobox
CD48Bgeelymph node1.00infobox
CD48Bgeeepithelium of colon1.00infobox
CD48Bgeemesenteric lymph nodes1.00infobox
CD48Bgeestroma of bone marrow1.00infobox
CD48Bgeethymus1.00infobox
CD48Bgeecalvaria1.00infobox
CD48Bgeesubcutaneous adipose tissue1.00infobox
CD48Bgeewhite adipose tissue1.00infobox
CD48Bgeepharynx1.00infobox
CD48BioGPSMore reference expression data1.00infobox
CD48Chr.Chromosome 1 (human)1.00infobox
CD48Chr.Chromosome 1 (mouse)1.00infobox
CD48DatabasesNCBI: entry; OMA: entry1.00infobox
CD48End160,711,831 bp1.00infobox
CD48End171,532,826 bp1.00infobox
CD48EnsemblENSG000001170911.00infobox
CD48Entrez9621.00infobox
CD48External IDsOMIM: 109530; MGI: 88339; GeneCards: CD481.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around CD48 bring nearby vocabulary together. In this analysis, examples include Cd2, Cell and Gpi. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • CD48
    • Cd2
    • Cell
    • Gpi
    • Activation
    • Protein
    • Anchor
    • Differentiation
    • Cells
    • Gene
    • Human
    • Blood
    • Cd244
  • cd48
    • Cd2
    • Cell
    • Gpi
    • Activation
    • Protein
    • Anchor
    • Differentiation
    • Cells
    • Gene
    • Human
    • Blood
    • Cd244
  • cellular differentiation
    • Function
    • Immune
    • Mouse
    • Protein
    • Blood
    • Domain
    • Expressed
    • Molecular
    • Signal
    • Signaling
    • Anchor
    • Band
  • antigen
    • Cellular
    • Signaling
    • Differentiation
    • Gene
    • Protein
    • Cluster
    • Function
    • Immune
    • Molecule
    • Mouse
    • Slamf2
    • Blood
  • gpi anchor
    • Gpi
    • Signal
    • Blood
    • Domain
    • Protein
    • Cell
    • Surface
    • Cd48
    • Cellular
    • Function
    • Immune
    • Mouse
  • peripheral blood lymphocytes
    • Expressed
    • Anchor
    • Cells
    • Immune
    • Protein
    • Gpi
    • Blood
    • Cellular
    • Function
    • Lymphocytes
    • Mouse
    • Domain
  • antigen-presenting cell
    • Gpi
    • Function
    • Domain
    • Molecular
    • Signal
    • Anchor
    • Chromosome
    • Location
    • Surface
    • Bp
    • Chr
    • Gene
  • gene
    • Location
    • Human
    • Chromosome
    • Bp
    • Chr
    • Function
    • Molecule
    • Mouse
    • Slamf2
    • Signaling
    • Band
    • Protein

Connections between topic areas Semantic bridges

For CD48, one of the stronger structural bridges in this analysis connects CD48 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
CD48Overview · splits 26 ⟂ 16
CD48Function · splits 32 ⟂ 10
CD48Structure · splits 34 ⟂ 8
CD48Interactions · splits 37 ⟂ 5

Map overview Semantic statistics

CD48

Nodes42
Edges41
Triples111
Avg. degree1.95
Density0.047619
Components1

Source & methodology

TTTA analyzes the structure around CD48 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Structure & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — CD48 · EN edition · Analysis: TopicsToTalkAbout

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