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Neprilysin

Neprilysin (/ˌnɛprɪˈlaɪsɪn/; also known as membrane metallo-endopeptidase (MME), neutral endopeptidase (NEP), cluster of differentiation 10 (CD10) and common acute lymphoblastic leukemia antigen (CALLA)) is an enzyme that in humans is encoded by the MME gene. Neprilysin is a zinc-dependent metalloprotease that cleaves peptides at the amino side of…

Immunochemistry, Signaling peptides & Inhibitors

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3.4.24.11
↗
Aliases
MME, CALLA, CD10, NEP, SFE, membrane metallo-endopeptidase, membrane metalloendopeptidase, CMT2T, SCA43
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1DMT, 1R1H, 1R1I, 1R1J, 1Y8J, 2QPJ, 2YB9, 4CTH, 5JMY
Band
3q25.2 · 3 E1|3 29.97 cM
Bgee
jejunal mucosa · glomerulus · metanephric glomerulus · stromal cell of endometrium · duodenum
BioGPS
More reference expression data

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Overview

Amyloid beta regulation

Signaling peptides

Inhibitors

Immunochemistry

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Neprilysin

Nodes93
Edges92
Triples169
Avg. degree1.98
Density0.021505
Components1

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Neprilysin

Top relations

Gene ontology · 56
Neprilysin → ageing, amyloid-beta clearance, amyloid-beta clearance by cellular catabolic process, amyloid-beta metabolic process, angiotensin maturation, axon, brush border, cardiolipin binding, cell surface, cellular response to cytokine stimulus, cellular response to UV-A, cellular response to UV-B, creatinine metabolic process, cytoplasm, cytoplasmic vesicle, dendrite, early endosome, endopeptidase activity, exopeptidase activity, extracellular exosome
Bgee · 20
Neprilysin → blood, calvaria, duodenum, epithelium of lens, external carotid artery, glomerulus, Gonadal ridge, human kidney, jejunal mucosa, kidney tubule, lobe of prostate, metanephric glomerulus, molar, mucosa of ileum, prostate, stromal cell of endometrium, sural nerve, vas deferens, vestibular membrane of cochlear duct, vestibular sensory epithelium
RNA expression pattern · 20
Neprilysin → blood, calvaria, duodenum, epithelium of lens, external carotid artery, glomerulus, Gonadal ridge, human kidney, jejunal mucosa, kidney tubule, lobe of prostate, metanephric glomerulus, molar, mucosa of ileum, prostate, stromal cell of endometrium, sural nerve, vas deferens, vestibular membrane of cochlear duct, vestibular sensory epithelium
related to External links · 15
Neprilysin → Archived, M13, Medicine, Medicine Medical Subject Headings, MeSH, National Library, Overview, P08473, PDB, PDBe-KB, The MEROPS, This, UniProt, United States National Library, Wayback MachineNeprilysin
related to Signaling peptides · 10
Neprilysin → Associations, CALLA, CD10, Ceropegia, In, Inhibitors, Kniphofia, Pavetta, Plectranthus, Some
related to Amyloid beta regulation · 5
Neprilysin → Alzheimer's, Alzheimer's-like, Because, Declining, Neprilysin-deficient
Band · 2
Neprilysin → 3 E1|3 29.97 cM, 3q25.2
Chr. · 2
Neprilysin → Chromosome 3 (human), Chromosome 3 (mouse)
End · 2
Neprilysin → 155,183,704 bp, 63,293,451 bp
related to Inhibitors · 2
Neprilysin → Inhibitors, Some

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Important terminology

cd10 cell carcinoma cells leukemia lymphoma also human bp peptide activity expression gene chr band follicular acute peptides cancer expressed

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Neprilysin3.4.24.11↗1.00infobox
NeprilysinAliasesMME, CALLA, CD10, NEP, SFE, membrane metallo-endopeptidase, membrane metalloendopeptidase, CMT2T, SCA431.00infobox
NeprilysinAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1DMT, 1R1H, 1R1I, 1R1J, 1Y8J, 2QPJ, 2YB9, 4CTH, 5JMY1.00infobox
NeprilysinBand3q25.21.00infobox
NeprilysinBand3 E1|3 29.97 cM1.00infobox
NeprilysinBgeejejunal mucosa1.00infobox
NeprilysinBgeeglomerulus1.00infobox
NeprilysinBgeemetanephric glomerulus1.00infobox
NeprilysinBgeestromal cell of endometrium1.00infobox
NeprilysinBgeeduodenum1.00infobox
NeprilysinBgeekidney tubule1.00infobox
NeprilysinBgeesural nerve1.00infobox
NeprilysinBgeehuman kidney1.00infobox
NeprilysinBgeemucosa of ileum1.00infobox
NeprilysinBgeeblood1.00infobox
NeprilysinBgeeepithelium of lens1.00infobox
NeprilysinBgeemolar1.00infobox
NeprilysinBgeevestibular sensory epithelium1.00infobox
NeprilysinBgeeprostate1.00infobox
NeprilysinBgeeGonadal ridge1.00infobox
NeprilysinBgeelobe of prostate1.00infobox
NeprilysinBgeevestibular membrane of cochlear duct1.00infobox
NeprilysinBgeeexternal carotid artery1.00infobox
NeprilysinBgeecalvaria1.00infobox
NeprilysinBgeevas deferens1.00infobox
NeprilysinBioGPSMore reference expression data1.00infobox
NeprilysinChr.Chromosome 3 (human)1.00infobox
NeprilysinChr.Chromosome 3 (mouse)1.00infobox
NeprilysinDatabasesNCBI: entry; OMA: entry1.00infobox
NeprilysinEnd155,183,704 bp1.00infobox

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