Find related topics. | Discover entities. | See connections. | Build a topical map.
Building topical map: Starting…
Carboxylesterase 1: Standards, Function & Clinical significance
Liver carboxylesterase 1 also known as carboxylesterase 1 (CES1, hCE-1 or CES1A1) is an enzyme that in humans is encoded by the CES1 gene. The protein is also historically known as serine esterase 1 (SES1), monocyte esterase and cholesterol ester hydrolase (CEH). Three transcript variants encoding three different isoforms have been found for this gene.…
Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.
More settings
Carboxylesterase 1 topic overview
The analysis highlights Standards, Function and Clinical significance as prominent areas in the source structure around Carboxylesterase 1.
Related topics
27
Source areas
3
Connected nodes
30
Extracted relationships
101
Concept neighborhoods
13
Bridge connections
30
What this topic covers Research coverage
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Clinical significance · 9 topics
Function · 9 topics
Overview · 9 topics
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
Key facts & relationships
High-confidence facts extracted from structured source data. Use them as anchors for further research.
A structured outline of related entities, concepts and subtopics. Open any item to build a new map centered on it.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
How Carboxylesterase 1 connects Entity context
Entity context groups extracted connections by relationship type. Counts show recurrence in the analyzed source; the examples are research signals, not claims about importance.
The extracted context around Carboxylesterase 1 shows recurring relationship patterns in the source. For example, Carboxylesterase 1 → apex of heart, brown adipose tissue, Descending thoracic aorta, epithelium of colon, gallbladder, lacrimal gland, left lung, muscle layer of sigmoid colon, nasal epithelium, olfactory epithelium, olfactory zone of nasal mucosa, right lobe of liver, right lung, right lung lobe, smooth muscle tissue, superior surface of tongue, tunica adventitia of aorta, upper lobe of left lung, white adipose tissue Another extracted example is Carboxylesterase 1 → angiotensin maturation, carboxylic ester hydrolase activity, cholesterol biosynthetic process, cholesterol ester hydrolysis involved in cholesterol transport, cytosol, endoplasmic reticulum, endoplasmic reticulum lumen, epithelial cell differentiation, extracellular space, hydrolase activity, lipid catabolic process, medium-chain fatty acid metabolic process, methyl indole-3-acetate esterase activity, methylumbelliferyl-acetate deacetylase activity, response to toxic substance, sterol esterase activity, triglyceride lipase activity, xenobiotic metabolic process. Use these groups to spot repeated connection types before inspecting the individual relationships.
Carboxylesterase 1
Top relations
Bgee· 19
Carboxylesterase 1 → apex of heart, brown adipose tissue, Descending thoracic aorta, epithelium of colon, gallbladder, lacrimal gland, left lung, muscle layer of sigmoid colon, nasal epithelium, olfactory epithelium, olfactory zone of nasal mucosa, right lobe of liver, right lung, right lung lobe, smooth muscle tissue, superior surface of tongue, tunica adventitia of aorta, upper lobe of left lung, white adipose tissue
RNA expression pattern· 19
Carboxylesterase 1 → apex of heart, brown adipose tissue, Descending thoracic aorta, epithelium of colon, gallbladder, lacrimal gland, left lung, muscle layer of sigmoid colon, nasal epithelium, olfactory epithelium, olfactory zone of nasal mucosa, right lobe of liver, right lung, right lung lobe, smooth muscle tissue, superior surface of tongue, tunica adventitia of aorta, upper lobe of left lung, white adipose tissue
Relationships are represented as Subject → Predicate → Object triples. Confidence describes extraction strength, not the real-world importance of a relationship; lower-confidence rows may be contextual rather than explicit.
TTTA extracted 101 structured relationships around Carboxylesterase 1. Examples in this analysis include Carboxylesterase 1 → 3.1.1.1 → ↗ and Carboxylesterase 1 → Aliases → CES1, ACAT, CE-1, CEH, CES2, HMSE, HMSE1, PCE-1, REH, SES1, TGH, hCE-1, carboxylesterase 1. The table shows each extracted connection, where it came from and its confidence.
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1MX1, 1MX5, 1MX9, 1YA4, 1YA8, 1YAH, 1YAJ, 2DQY, 2DQZ, 2DR0, 2H7C, 2HRQ, 2HRR, 3K9B, 4AB1, 5A7F, 5A7H, 5A7G
1.00
infobox
Carboxylesterase 1
Band
16q12.2
1.00
infobox
Carboxylesterase 1
Band
8|8 C5
1.00
infobox
Carboxylesterase 1
Bgee
right lobe of liver
1.00
infobox
Carboxylesterase 1
Bgee
gallbladder
1.00
infobox
Carboxylesterase 1
Bgee
right lung
1.00
infobox
Carboxylesterase 1
Bgee
olfactory zone of nasal mucosa
1.00
infobox
Carboxylesterase 1
Bgee
upper lobe of left lung
1.00
infobox
Carboxylesterase 1
Bgee
smooth muscle tissue
1.00
infobox
Carboxylesterase 1
Bgee
apex of heart
1.00
infobox
Carboxylesterase 1
Bgee
muscle layer of sigmoid colon
1.00
infobox
Carboxylesterase 1
Bgee
Descending thoracic aorta
1.00
infobox
Carboxylesterase 1
Bgee
epithelium of colon
1.00
infobox
Carboxylesterase 1
Bgee
white adipose tissue
1.00
infobox
Carboxylesterase 1
Bgee
lacrimal gland
1.00
infobox
Carboxylesterase 1
Bgee
right lung lobe
1.00
infobox
Carboxylesterase 1
Bgee
nasal epithelium
1.00
infobox
Carboxylesterase 1
Bgee
tunica adventitia of aorta
1.00
infobox
Carboxylesterase 1
Bgee
olfactory epithelium
1.00
infobox
Carboxylesterase 1
Bgee
superior surface of tongue
1.00
infobox
Carboxylesterase 1
Bgee
brown adipose tissue
1.00
infobox
Carboxylesterase 1
Bgee
left lung
1.00
infobox
Carboxylesterase 1
BioGPS
n/a
1.00
infobox
Carboxylesterase 1
Chr.
Chromosome 16 (human)
1.00
infobox
Carboxylesterase 1
Chr.
Chromosome 8 (mouse)
1.00
infobox
Carboxylesterase 1
Databases
NCBI: entry; OMA: entry
1.00
infobox
No triples extracted yet.
Related concept clusters Concept neighborhoods
Concept neighborhoods group terms that sit near one another in the extracted graph. They are useful for discovering adjacent language and context, but proximity does not by itself imply a factual relationship.
The concept neighborhoods around Carboxylesterase 1 bring nearby vocabulary together. In this analysis, examples include Function, Gene and Hce-1. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
Carboxylesterase 1
Function
Gene
Hce-1
Search
Activity
Liver
Location
Chromosome
Human
Ces1
Bp
Chr
carboxylesterase 1
Function
Gene
Hce-1
Search
Activity
Liver
Location
Chromosome
Human
Ces1
Bp
Chr
gene
Location
Chromosome
Human
Bp
Chr
End
Function
Hce-1
Mouse
Search
Activity
Liver
carboxylesterase
Function
Gene
Hce-1
Search
Activity
Liver
Location
Chromosome
Human
Ces1
Bp
Chr
esterase
Serine
Cholesterol
Ester
Hydrolase
Protein
Ceh
End
Function
Lung
Mouse
Search
Ses1
ester
Esterase
Lung
Serine
Hydrolase
Protein
Ceh
End
Function
Mouse
Search
Ses1
Acid
hydrolase
Serine
Protein
Ceh
End
Function
Lung
Mouse
Search
Ses1
Acid
Activity
Known
alpha/beta fold hydrolase
Serine
Protein
Ceh
End
Function
Lung
Mouse
Search
Ses1
Acid
Activity
Known
Connections between topic areas Semantic bridges
Semantic bridges connect parts of the graph that would otherwise be more separate. A bridge is a structural signal in this analysis, not a claim that the two topic areas are equivalent.
For Carboxylesterase 1, one of the stronger structural bridges in this analysis connects Carboxylesterase 1 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
Number of nodes, edges, triples, density and central hubs. Use it to gauge the size and connectivity of the map.
Carboxylesterase 1
Nodes31
Edges30
Triples101
Avg. degree1.94
Density0.064516
Components1
Source & methodology
TTTA analyzes the structure around Carboxylesterase 1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Standards, Function & Clinical significance, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
