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CALM2: Clinical significance, Interactions & Overview

Calmodulin 2 is a protein that in humans is encoded by the CALM2 gene. A member of the calmodulin family of signaling molecules, it is an intermediary between calcium ions, which act as a second messenger, and many intracellular processes, such as the contraction of cardiac muscle.

Language: English [EN]
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CALM2 topic overview

The analysis highlights Clinical significance, Interactions and Overview as prominent areas in the source structure around CALM2.

Related topics
11
Source areas
3
Connected nodes
14
Extracted relationships
116
Concept neighborhoods
10
Bridge connections
14

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 5 topics
Clinical significance · 4 topics
Interactions · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
CALM2, CAMII, PHKD, PHKD2, LQT15, caM, calmodulin 2 (phosphorylase kinase, delta), calmodulin 2, CAMC, CAM1, CAMIII, CAM3, CALM, CALML2
Band
2p21
Bgee
middle temporal gyrus · Brodmann area 23 · orbitofrontal cortex · visceral pleura · pons
BioGPS
n/a
Chr.
Chromosome 2 (human)
Databases
NCBI: entry; OMA: entry

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Clinical significance

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How CALM2 connects Entity context

The extracted context around CALM2 shows recurring relationship patterns in the source. For example, CALM2 → activation of adenylate cyclase activity, adenylate cyclase activator activity, adenylate cyclase binding, calcium channel complex, calcium channel inhibitor activity, calcium ion binding, calcium-dependent protein binding, calcium-mediated signaling, catalytic complex, centrosome, cytoplasm, cytoskeleton, detection of calcium ion, disordered domain specific binding, establishment of protein localization to membrane, establishment of protein localization to mitochondrial membrane, G protein-coupled receptor signaling pathway, G2/M transition of mitotic cell cycle, growth cone, metal ion binding Another extracted example is CALM2 → Brodmann area 23, germinal epithelium, lateral nuclear group of thalamus, middle temporal gyrus, occipital lobe, orbitofrontal cortex, parietal pleura, pons, prefrontal cortex, visceral pleura. Use these groups to spot repeated connection types before inspecting the individual relationships.

CALM2

Top relations

Gene ontology · 72
CALM2 → activation of adenylate cyclase activity, adenylate cyclase activator activity, adenylate cyclase binding, calcium channel complex, calcium channel inhibitor activity, calcium ion binding, calcium-dependent protein binding, calcium-mediated signaling, catalytic complex, centrosome, cytoplasm, cytoskeleton, detection of calcium ion, disordered domain specific binding, establishment of protein localization to membrane, establishment of protein localization to mitochondrial membrane, G protein-coupled receptor signaling pathway, G2/M transition of mitotic cell cycle, growth cone, metal ion binding
Bgee · 10
CALM2 → Brodmann area 23, germinal epithelium, lateral nuclear group of thalamus, middle temporal gyrus, occipital lobe, orbitofrontal cortex, parietal pleura, pons, prefrontal cortex, visceral pleura
RNA expression pattern · 10
CALM2 → Brodmann area 23, germinal epithelium, lateral nuclear group of thalamus, middle temporal gyrus, occipital lobe, orbitofrontal cortex, parietal pleura, pons, prefrontal cortex, visceral pleura
related to Clinical significance · 5
CALM2 → Australia, Due, In, Kathleen Folbigg, Mutations
related to External links · 2
CALM2 → Human CALM2, UCSC Genome Browser
Aliases · 1
CALM2 → CALM2, CAMII, PHKD, PHKD2, LQT15, caM, calmodulin 2 (phosphorylase kinase, delta), calmodulin 2, CAMC, CAM1, CAMIII, CAM3, CALM, CALML2
Band · 1
CALM2 → 2p21
BioGPS · 1
CALM2 → n/a
Chr. · 1
CALM2 → Chromosome 2 (human)
Databases · 1
CALM2 → NCBI: entry; OMA: entry

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

human gene calmodulin bp cardiac chr chromosome location protein band signaling calcium contraction muscle external family kinase 176 921 ucsc

CALM2 relationships Subject–Predicate–Object triples

TTTA extracted 116 structured relationships around CALM2. Examples in this analysis include CALM2 → Aliases → CALM2, CAMII, PHKD, PHKD2, LQT15, caM, calmodulin 2 (phosphorylase kinase, delta), calmodulin 2, CAMC, CAM1, CAMIII, CAM3, CALM, CALML2 and CALM2 → Band → 2p21. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
CALM2AliasesCALM2, CAMII, PHKD, PHKD2, LQT15, caM, calmodulin 2 (phosphorylase kinase, delta), calmodulin 2, CAMC, CAM1, CAMIII, CAM3, CALM, CALML21.00infobox
CALM2Band2p211.00infobox
CALM2Bgeemiddle temporal gyrus1.00infobox
CALM2BgeeBrodmann area 231.00infobox
CALM2Bgeeorbitofrontal cortex1.00infobox
CALM2Bgeevisceral pleura1.00infobox
CALM2Bgeepons1.00infobox
CALM2Bgeelateral nuclear group of thalamus1.00infobox
CALM2Bgeeoccipital lobe1.00infobox
CALM2Bgeegerminal epithelium1.00infobox
CALM2Bgeeparietal pleura1.00infobox
CALM2Bgeeprefrontal cortex1.00infobox
CALM2BioGPSn/a1.00infobox
CALM2Chr.Chromosome 2 (human)1.00infobox
CALM2DatabasesNCBI: entry; OMA: entry1.00infobox
CALM2End47,176,921 bp1.00infobox
CALM2EnsemblENSG000001439331.00infobox
CALM2Entrez8051.00infobox
CALM2External IDsOMIM: 114182; GeneCards: CALM21.00infobox
CALM2Gene location (Human)Gene location (Human)Chr.Chromosome 2 (human)Band2p21Start47,160,084 bpEnd47,176,921 bp1.00infobox
CALM2Gene ontologycalcium ion binding1.00infobox
CALM2Gene ontologyprotein binding1.00infobox
CALM2Gene ontologyadenylate cyclase binding1.00infobox
CALM2Gene ontologyadenylate cyclase activator activity1.00infobox
CALM2Gene ontologycalcium channel inhibitor activity1.00infobox
CALM2Gene ontologyprotein kinase binding1.00infobox
CALM2Gene ontologyprotein domain specific binding1.00infobox
CALM2Gene ontologytitin binding1.00infobox
CALM2Gene ontologyN-terminal myristoylation domain binding1.00infobox
CALM2Gene ontologyprotein serine/threonine kinase activator activity1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around CALM2 bring nearby vocabulary together. In this analysis, examples include Gene, Location and Human. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • CALM2
    • Gene
    • Location
    • Human
    • Kinase
    • Mutations
    • Protein
    • Ucsc
    • Bp
    • Calmodulin
    • Chr
    • Chromosome
    • Clinical
  • calm2
    • Gene
    • Location
    • Human
    • Kinase
    • Mutations
    • Protein
    • Ucsc
    • Bp
    • Calmodulin
    • Chr
    • Chromosome
    • Clinical
  • calmodulin
    • Gene
    • Act
    • Clinical
    • Encoded
    • External
    • Humans
    • Interactions
    • Intermediary
    • Intracellular
    • Ions
    • Links
    • Many
  • cardiac muscle
    • Contraction
    • Muscle
    • Signaling
    • Intermediary
    • Intracellular
    • Ions
    • Many
    • Member
    • Messenger
    • Molecules
    • Processes
    • Second
  • cardiac arrhythmias
    • Contraction
    • Muscle
    • Signaling
    • Intermediary
    • Intracellular
    • Ions
    • Many
    • Member
    • Messenger
    • Molecules
    • Processes
    • Second
  • gene
    • Location
    • Human
    • Kinase
    • Protein
    • Ucsc
    • Bp
    • Chr
    • Chromosome
    • Clinical
    • External
    • Humans
    • Interactions
  • clinical significance
    • Clinical
    • External
    • Interactions
    • Links
    • Reading
    • References
    • Significance
    • Kinase
    • Bp
    • Calmodulin
    • Chr
    • Chromosome
  • interactions
    • External
    • Links
    • Reading
    • References
    • Significance
    • Kinase
    • Location
    • Human

Connections between topic areas Semantic bridges

For CALM2, one of the stronger structural bridges in this analysis connects CALM2 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
CALM2 — Overview · splits 9 ⟂ 6
CALM2 — Clinical significance · splits 10 ⟂ 5
CALM2 — Interactions · splits 12 ⟂ 3

Map overview Semantic statistics

CALM2

Nodes15
Edges14
Triples116
Avg. degree1.87
Density0.133333
Components1

Source & methodology

TTTA analyzes the structure around CALM2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Clinical significance, Interactions & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — CALM2 · EN edition · Analysis: TopicsToTalkAbout

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