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BOP1: Function, Structure & Overview

Ribosome biogenesis protein BOP1 is a protein that in humans is encoded by the BOP1 gene. It is a WD40 repeat-containing nucleolar protein involved in rRNA processing, thereby controlling the cell cycle. It is required for the maturation of the 25S and 5.8S ribosomal RNAs. It may serve as an essential factor in ribosome formation that coordinates…

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BOP1 topic overview

The analysis highlights Function, Structure and Overview as prominent areas in the source structure around BOP1.

Related topics: 25
Source areas: 3
Connected nodes: 28
Extracted relationships: 96
Concept neighborhoods: 13
Bridge connections: 28

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 17 topics

Overview · 7 topics

Structure · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases: BOP1, block of proliferation 1, BOP1 ribosomal biogenesis factor
Band: 8q24.3 · 15 D3|15 35.91 cM
Bgee: right lobe of thyroid gland · right hemisphere of cerebellum · left lobe of thyroid gland · pituitary gland · anterior pituitary
BioGPS: More reference expression data
Chr.: Chromosome 8 (human) · Chromosome 15 (mouse)
Databases: NCBI: entry; OMA: entry

Suggested research paths

A focused starting point derived from the topic graph, ranked independently of the source article order.

Start with these areas

Function

Biogenesis Chromosome segregation Cytoskeleton Erb1p GRWD1

Structure

N-terminal

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How BOP1 connects Entity context

The extracted context around BOP1 shows recurring relationship patterns in the source. For example, BOP1 → anterior pituitary, apex of heart, embryo, epiblast, gastrocnemius muscle, left lobe of thyroid gland, mandibular prominence, mucosa of transverse colon, otic placode, otic vesicle, pituitary gland, primitive streak, right frontal lobe, right hemisphere of cerebellum, right lobe of thyroid gland, right uterine tube, saccule, somite, yolk sac Another extracted example is BOP1 → cell population proliferation, cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), nucleolus, nucleoplasm, nucleus, PeBoW complex, preribosome, large subunit precursor, protein binding, regulation of cell cycle, regulation of signal transduction by p53 class mediator, ribonucleoprotein complex, ribonucleoprotein complex binding, ribosomal large subunit assembly, ribosomal large subunit biogenesis, ribosome biogenesis, RNA binding, rRNA processing. Use these groups to spot repeated connection types before inspecting the individual relationships.

BOP1

Top relations

Bgee · 19

BOP1 → anterior pituitary, apex of heart, embryo, epiblast, gastrocnemius muscle, left lobe of thyroid gland, mandibular prominence, mucosa of transverse colon, otic placode, otic vesicle, pituitary gland, primitive streak, right frontal lobe, right hemisphere of cerebellum, right lobe of thyroid gland, right uterine tube, saccule, somite, yolk sac

Gene ontology · 19

BOP1 → cell population proliferation, cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), nucleolus, nucleoplasm, nucleus, PeBoW complex, preribosome, large subunit precursor, protein binding, regulation of cell cycle, regulation of signal transduction by p53 class mediator, ribonucleoprotein complex, ribonucleoprotein complex binding, ribosomal large subunit assembly, ribosomal large subunit biogenesis, ribosome biogenesis, RNA binding, rRNA processing

RNA expression pattern · 19

related to Function · 14

BOP1 → Bop1/Pes1, Bop1/WDR12, Deregulation, Elevated, GRWD1, In Giardia, Nop7p-Erb1p-Ytm1p, ORC6L, PeBoW, PES1, Pes1-Bop1-WDR12, RPL3, The, The Pes1-Bop1

Band · 2

BOP1 → 15 D3|15 35.91 cM, 8q24.3

Chr. · 2

BOP1 → Chromosome 15 (mouse), Chromosome 8 (human)

End · 2

BOP1 → 144,291,438 bp, 76,361,477 bp

related to External links · 2

BOP1 → Human BOP1, UCSC Genome Browser

related to Structure · 2

BOP1 → BOP1NT, N-terminal

Aliases · 1

BOP1 → BOP1, block of proliferation 1, BOP1 ribosomal biogenesis factor

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

biogenesis human ribosome bp protein gene chr band chromosome complex location processing ribosomal cell involved proliferation mouse humans pebow rrna

BOP1 relationships Subject–Predicate–Object triples

TTTA extracted 96 structured relationships around BOP1. Examples in this analysis include BOP1 → Aliases → BOP1, block of proliferation 1, BOP1 ribosomal biogenesis factor and BOP1 → Band → 8q24.3. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
BOP1	Aliases	BOP1, block of proliferation 1, BOP1 ribosomal biogenesis factor	1.00	infobox
BOP1	Band	8q24.3	1.00	infobox
BOP1	Band	15 D3\|15 35.91 cM	1.00	infobox
BOP1	Bgee	right lobe of thyroid gland	1.00	infobox
BOP1	Bgee	right hemisphere of cerebellum	1.00	infobox
BOP1	Bgee	left lobe of thyroid gland	1.00	infobox
BOP1	Bgee	pituitary gland	1.00	infobox
BOP1	Bgee	anterior pituitary	1.00	infobox
BOP1	Bgee	right uterine tube	1.00	infobox
BOP1	Bgee	gastrocnemius muscle	1.00	infobox
BOP1	Bgee	right frontal lobe	1.00	infobox
BOP1	Bgee	mucosa of transverse colon	1.00	infobox
BOP1	Bgee	apex of heart	1.00	infobox
BOP1	Bgee	otic placode	1.00	infobox
BOP1	Bgee	saccule	1.00	infobox
BOP1	Bgee	otic vesicle	1.00	infobox
BOP1	Bgee	epiblast	1.00	infobox
BOP1	Bgee	somite	1.00	infobox
BOP1	Bgee	embryo	1.00	infobox
BOP1	Bgee	yolk sac	1.00	infobox
BOP1	Bgee	primitive streak	1.00	infobox
BOP1	Bgee	mandibular prominence	1.00	infobox
BOP1	BioGPS	More reference expression data	1.00	infobox
BOP1	Chr.	Chromosome 8 (human)	1.00	infobox
BOP1	Chr.	Chromosome 15 (mouse)	1.00	infobox
BOP1	Databases	NCBI: entry; OMA: entry	1.00	infobox
BOP1	End	144,291,438 bp	1.00	infobox
BOP1	End	76,361,477 bp	1.00	infobox
BOP1	Ensembl	ENSG00000261236 ENSG00000285301	1.00	infobox
BOP1	Entrez	23246	1.00	infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around BOP1 bring nearby vocabulary together. In this analysis, examples include Gene, Protein and Human. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

BOP1
- Gene
- Protein
- Human
- Location
- Function
- Humans
- Pebow
- Proliferation
- Ribosomal
- Chromosome
- Complex
- Bp
bop1
- Gene
- Protein
- Human
- Location
- Function
- Humans
- Pebow
- Proliferation
- Ribosomal
- Chromosome
- Complex
- Bp
protein
- Bop1
- Cycle
- Rrna
- Cell
- Involved
- Pebow
- Processing
- Complex
- Gene
- Ribosome
- 8s
- D3
gene
- Location
- Human
- Chromosome
- Bp
- Chr
- D3
- End
- Function
- Mouse
- Proliferation
- Ribosomal
- Band
cell
- Cycle
- Rrna
- Involved
- Pebow
- Processing
- Proliferation
- Complex
- Protein
- Ribosome
- 8s
- D3
- End
biogenesis
- Ribosome
- Proliferation
- Complex
- Gene
- Entry
- Function
- Cell
- Involved
- Pebow
- Ribosomal
- Chromosome
- Location
chromosome segregation
- Bp
- Human
- Band
- Location
- D3
- End
- Function
- Gene
- Mouse
- Proliferation
- Ribosomal
- External
function
- Proliferation
- Ribosomal
- Chromosome
- Location
- Bp
- Chr
- Gene
- D3
- End
- Entry
- Human
- Maturation

Connections between topic areas Semantic bridges

For BOP1, one of the stronger structural bridges in this analysis connects BOP1 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

BOP1 — Function · splits 11 ⟂ 18

BOP1 — Overview · splits 21 ⟂ 8

Map overview Semantic statistics

BOP1

Nodes29

Edges28

Triples96

Avg. degree1.93

Density0.068966

Components1

Source & methodology

TTTA analyzes the structure around BOP1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Structure & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — BOP1 · EN edition · Analysis: TopicsToTalkAbout

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