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BMI1

Polycomb complex protein BMI-1 also known as polycomb group RING finger protein 4 (PCGF4) or RING finger protein 51 (RNF51) is a protein that in humans is encoded by the BMI1 gene (B cell-specific Moloney murine leukemia virus integration site 1). BMI1 is a polycomb ring finger oncogene.

Function, Clinical significance & Interactions

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Function

P16P19Cell cycleHematopoiesisCerebellum
12 related topics

Clinical significance

Mantle cell lymphomasGlioblastoma multiformeOvarian cancerProstaticPancreatic
8 related topics

Interactions

InteractPHC1PHC2RING1ZBTB16
5 related topics

Structure

N-terminusHelix-turn-helix
2 related topics

Key facts & relationships

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Aliases
BMI1, FLVI2/PCGF4, RNF51, flvi-2/bmi-1, BMI1 proto-oncogene, polycomb ring finger
Available structures
Available structuresPDBHuman UniProt search: PDBe RCSB List of PDB id codes2H0D, 3RPG, 4R8P
Band
10p12.2
Bgee
germinal epithelium · Epithelium of choroid plexus · endothelial cell · optic nerve · Brodmann area 23
BioGPS
More reference expression data
Chr.
Chromosome 10 (human)

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Overview

Structure

Function

Clinical significance

Interactions

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Map overview Semantic statistics

BMI1

Nodes40
Edges39
Triples102
Avg. degree1.95
Density0.05
Components1

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BMI1

Top relations

Gene ontology · 25
BMI1 → chromatin organization, cytoplasm, cytosol, hemopoiesis, histone H2A-K119 monoubiquitination, metal ion binding, negative regulation of G0 to G1 transition, negative regulation of gene expression, epigenetic, negative regulation of transcription by RNA polymerase II, nuclear body, nucleoplasm, nucleus, PcG protein complex, positive regulation of fibroblast proliferation, positive regulation of ubiquitin-protein transferase activity, PRC1 complex, promoter-specific chromatin binding, protein binding, regulation of gene expression, regulation of transcription, DNA-templated
Bgee · 10
BMI1 → Brodmann area 23, corpus callosum, endothelial cell, Epithelium of choroid plexus, germinal epithelium, optic nerve, parietal pleura, retinal pigment epithelium, tibia, visceral pleura
RNA expression pattern · 10
BMI1 → Brodmann area 23, corpus callosum, endothelial cell, Epithelium of choroid plexus, germinal epithelium, optic nerve, parietal pleura, retinal pigment epithelium, tibia, visceral pleura
related to Structure · 10
BMI1 → BMI-1, CRD, Da, E3, It, N-terminal, N-terminus, RING, The, The BMI-1
related to Clinical significance · 9
BMI1 → According, Alzheimer's, BMI-1, Canadian, Colorectal, Inhibiting BMI1, Its, Overexpression, The
related to External links · 9
BMI1 → BMI-1, Human BMI1, Overview, P35226, PDB, PDBe-KB, Polycomb, UCSC Genome Browser, UniProt
related to Function · 6
BMI1 → DNA, Given, However, Loss, Mo-MLV, Recently
related to Interactions · 3
BMI1 → PHC1, PHC2, RING1
Aliases · 1
BMI1 → BMI1, FLVI2/PCGF4, RNF51, flvi-2/bmi-1, BMI1 proto-oncogene, polycomb ring finger
Available structures · 1
BMI1 → Available structuresPDBHuman UniProt search: PDBe RCSB List of PDB id codes2H0D, 3RPG, 4R8P

Important terminology Word statistics

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Important terminology

bmi-1 gene ring finger cell human polycomb stem protein also 10 chromosome bp uniprot domain proliferation complex chr development cells

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
BMI1AliasesBMI1, FLVI2/PCGF4, RNF51, flvi-2/bmi-1, BMI1 proto-oncogene, polycomb ring finger1.00infobox
BMI1Available structuresAvailable structuresPDBHuman UniProt search: PDBe RCSB List of PDB id codes2H0D, 3RPG, 4R8P1.00infobox
BMI1Band10p12.21.00infobox
BMI1Bgeegerminal epithelium1.00infobox
BMI1BgeeEpithelium of choroid plexus1.00infobox
BMI1Bgeeendothelial cell1.00infobox
BMI1Bgeeoptic nerve1.00infobox
BMI1BgeeBrodmann area 231.00infobox
BMI1Bgeevisceral pleura1.00infobox
BMI1Bgeecorpus callosum1.00infobox
BMI1Bgeeretinal pigment epithelium1.00infobox
BMI1Bgeetibia1.00infobox
BMI1Bgeeparietal pleura1.00infobox
BMI1BioGPSMore reference expression data1.00infobox
BMI1Chr.Chromosome 10 (human)1.00infobox
BMI1DatabasesNCBI: entry; OMA: entry1.00infobox
BMI1End22,331,484 bp1.00infobox
BMI1EnsemblENSG000001682831.00infobox
BMI1Entrez6481.00infobox
BMI1External IDsOMIM: 164831; GeneCards: BMI11.00infobox
BMI1Gene location (Human)Gene location (Human)Chr.Chromosome 10 (human)Band10p12.2Start22,321,099 bpEnd22,331,484 bp1.00infobox
BMI1Gene ontologypromoter-specific chromatin binding1.00infobox
BMI1Gene ontologyRING-like zinc finger domain binding1.00infobox
BMI1Gene ontologymetal ion binding1.00infobox
BMI1Gene ontologyprotein binding1.00infobox
BMI1Gene ontologyzinc ion binding1.00infobox
BMI1Gene ontologycytoplasm1.00infobox
BMI1Gene ontologyubiquitin ligase complex1.00infobox
BMI1Gene ontologynucleoplasm1.00infobox
BMI1Gene ontologyPRC1 complex1.00infobox

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