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BMI1: Function, Clinical significance & Interactions

Polycomb complex protein BMI-1 also known as polycomb group RING finger protein 4 (PCGF4) or RING finger protein 51 (RNF51) is a protein that in humans is encoded by the BMI1 gene (B cell-specific Moloney murine leukemia virus integration site 1). BMI1 is a polycomb ring finger oncogene.

Language: English [EN]
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BMI1 topic overview

The analysis highlights Function, Clinical significance and Interactions as prominent areas in the source structure around BMI1.

Related topics
34
Source areas
5
Connected nodes
39
Extracted relationships
102
Concept neighborhoods
15
Bridge connections
39

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 12 topics
Clinical significance · 8 topics
Overview · 7 topics
Interactions · 5 topics
Structure · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
BMI1, FLVI2/PCGF4, RNF51, flvi-2/bmi-1, BMI1 proto-oncogene, polycomb ring finger
Available structures
Available structuresPDBHuman UniProt search: PDBe RCSB List of PDB id codes2H0D, 3RPG, 4R8P
Band
10p12.2
Bgee
germinal epithelium · Epithelium of choroid plexus · endothelial cell · optic nerve · Brodmann area 23
BioGPS
More reference expression data
Chr.
Chromosome 10 (human)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Function

Clinical significance

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How BMI1 connects Entity context

The extracted context around BMI1 shows recurring relationship patterns in the source. For example, BMI1 → chromatin organization, cytoplasm, cytosol, hemopoiesis, histone H2A-K119 monoubiquitination, metal ion binding, negative regulation of G0 to G1 transition, negative regulation of gene expression, epigenetic, negative regulation of transcription by RNA polymerase II, nuclear body, nucleoplasm, nucleus, PcG protein complex, positive regulation of fibroblast proliferation, positive regulation of ubiquitin-protein transferase activity, PRC1 complex, promoter-specific chromatin binding, protein binding, regulation of gene expression, regulation of transcription, DNA-templated Another extracted example is BMI1 → Brodmann area 23, corpus callosum, endothelial cell, Epithelium of choroid plexus, germinal epithelium, optic nerve, parietal pleura, retinal pigment epithelium, tibia, visceral pleura. Use these groups to spot repeated connection types before inspecting the individual relationships.

BMI1

Top relations

Gene ontology · 25
BMI1 → chromatin organization, cytoplasm, cytosol, hemopoiesis, histone H2A-K119 monoubiquitination, metal ion binding, negative regulation of G0 to G1 transition, negative regulation of gene expression, epigenetic, negative regulation of transcription by RNA polymerase II, nuclear body, nucleoplasm, nucleus, PcG protein complex, positive regulation of fibroblast proliferation, positive regulation of ubiquitin-protein transferase activity, PRC1 complex, promoter-specific chromatin binding, protein binding, regulation of gene expression, regulation of transcription, DNA-templated
Bgee · 10
BMI1 → Brodmann area 23, corpus callosum, endothelial cell, Epithelium of choroid plexus, germinal epithelium, optic nerve, parietal pleura, retinal pigment epithelium, tibia, visceral pleura
RNA expression pattern · 10
BMI1 → Brodmann area 23, corpus callosum, endothelial cell, Epithelium of choroid plexus, germinal epithelium, optic nerve, parietal pleura, retinal pigment epithelium, tibia, visceral pleura
related to Structure · 10
BMI1 → BMI-1, CRD, Da, E3, It, N-terminal, N-terminus, RING, The, The BMI-1
related to Clinical significance · 9
BMI1 → According, Alzheimer's, BMI-1, Canadian, Colorectal, Inhibiting BMI1, Its, Overexpression, The
related to External links · 9
BMI1 → BMI-1, Human BMI1, Overview, P35226, PDB, PDBe-KB, Polycomb, UCSC Genome Browser, UniProt
related to Function · 6
BMI1 → DNA, Given, However, Loss, Mo-MLV, Recently
related to Interactions · 3
BMI1 → PHC1, PHC2, RING1
Aliases · 1
BMI1 → BMI1, FLVI2/PCGF4, RNF51, flvi-2/bmi-1, BMI1 proto-oncogene, polycomb ring finger
Available structures · 1
BMI1 → Available structuresPDBHuman UniProt search: PDBe RCSB List of PDB id codes2H0D, 3RPG, 4R8P

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

bmi-1 gene ring finger cell human polycomb stem protein also 10 chromosome bp uniprot domain proliferation complex chr development cells

BMI1 relationships Subject–Predicate–Object triples

TTTA extracted 102 structured relationships around BMI1. Examples in this analysis include BMI1 → Aliases → BMI1, FLVI2/PCGF4, RNF51, flvi-2/bmi-1, BMI1 proto-oncogene, polycomb ring finger and BMI1 → Available structures → Available structuresPDBHuman UniProt search: PDBe RCSB List of PDB id codes2H0D, 3RPG, 4R8P. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
BMI1AliasesBMI1, FLVI2/PCGF4, RNF51, flvi-2/bmi-1, BMI1 proto-oncogene, polycomb ring finger1.00infobox
BMI1Available structuresAvailable structuresPDBHuman UniProt search: PDBe RCSB List of PDB id codes2H0D, 3RPG, 4R8P1.00infobox
BMI1Band10p12.21.00infobox
BMI1Bgeegerminal epithelium1.00infobox
BMI1BgeeEpithelium of choroid plexus1.00infobox
BMI1Bgeeendothelial cell1.00infobox
BMI1Bgeeoptic nerve1.00infobox
BMI1BgeeBrodmann area 231.00infobox
BMI1Bgeevisceral pleura1.00infobox
BMI1Bgeecorpus callosum1.00infobox
BMI1Bgeeretinal pigment epithelium1.00infobox
BMI1Bgeetibia1.00infobox
BMI1Bgeeparietal pleura1.00infobox
BMI1BioGPSMore reference expression data1.00infobox
BMI1Chr.Chromosome 10 (human)1.00infobox
BMI1DatabasesNCBI: entry; OMA: entry1.00infobox
BMI1End22,331,484 bp1.00infobox
BMI1EnsemblENSG000001682831.00infobox
BMI1Entrez6481.00infobox
BMI1External IDsOMIM: 164831; GeneCards: BMI11.00infobox
BMI1Gene location (Human)Gene location (Human)Chr.Chromosome 10 (human)Band10p12.2Start22,321,099 bpEnd22,331,484 bp1.00infobox
BMI1Gene ontologypromoter-specific chromatin binding1.00infobox
BMI1Gene ontologyRING-like zinc finger domain binding1.00infobox
BMI1Gene ontologymetal ion binding1.00infobox
BMI1Gene ontologyprotein binding1.00infobox
BMI1Gene ontologyzinc ion binding1.00infobox
BMI1Gene ontologycytoplasm1.00infobox
BMI1Gene ontologyubiquitin ligase complex1.00infobox
BMI1Gene ontologynucleoplasm1.00infobox
BMI1Gene ontologyPRC1 complex1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around BMI1 bring nearby vocabulary together. In this analysis, examples include Finger, Cell and Gene. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • BMI1
    • Finger
    • Cell
    • Gene
    • Human
    • Ring
    • Stem
    • Location
    • Cancer
    • Polycomb
    • Function
    • Oncogene
    • Pcgf4
  • bmi1
    • Finger
    • Cell
    • Gene
    • Human
    • Ring
    • Stem
    • Location
    • Cancer
    • Polycomb
    • Function
    • Oncogene
    • Pcgf4
  • gene
    • Human
    • Location
    • Chromosome
    • Function
    • Pcgf4
    • Rnf51
    • Search
    • Bp
    • Chr
    • Expression
    • Uniprot
    • Development
  • b cell
    • Stem
    • Genes
    • Location
    • Shown
    • Proliferation
    • Human
    • Gene
    • Function
    • Oncogene
    • P35226
    • Search
    • Binding
  • ring finger
    • Ring
    • Domain
    • Polycomb
    • Function
    • Pcgf4
    • Rnf51
    • Search
    • Binding
    • Bp
    • Chr
    • Location
    • Uniprot
  • cell cycle
    • Stem
    • Genes
    • Location
    • Shown
    • Proliferation
    • Human
    • Gene
    • Function
    • Oncogene
    • P35226
    • Search
    • Binding
  • mantle cell lymphomas
    • Stem
    • Genes
    • Location
    • Shown
    • Proliferation
    • Human
    • Gene
    • Function
    • Oncogene
    • P35226
    • Search
    • Binding
  • polycomb
    • Pcgf4
    • Pdb
    • Rnf51
    • Finger
    • Uniprot
    • Ring
    • Also
    • Protein
    • External
    • Bmi-1
    • Function
    • Gene

Connections between topic areas Semantic bridges

For BMI1, one of the stronger structural bridges in this analysis connects BMI1 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
BMI1 — Function · splits 27 ⟂ 13
BMI1 — Clinical significance · splits 31 ⟂ 9
BMI1 — Overview · splits 32 ⟂ 8
BMI1 — Interactions · splits 34 ⟂ 6
BMI1 — Structure · splits 37 ⟂ 3

Map overview Semantic statistics

BMI1

Nodes40
Edges39
Triples102
Avg. degree1.95
Density0.05
Components1

Source & methodology

TTTA analyzes the structure around BMI1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Clinical significance & Interactions, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — BMI1 · EN edition · Analysis: TopicsToTalkAbout

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