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PTPRC

Protein tyrosine phosphatase, receptor type, C also known as PTPRC is an enzyme that, in humans, is encoded by the PTPRC gene. PTPRC is also known as CD45 antigen (CD stands for cluster of differentiation), which was originally called leukocyte common antigen (LCA).

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3.1.3.48
Aliases
PTPRC, B220, CD45, CD45R, GP180, L-CA, LCA, LY5, T200, protein tyrosine phosphatase, receptor type C, protein tyrosine phosphatase receptor type C
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1YGU, 1YGR, 5FMV, 5FN6, 5FN7
Band
1q31.3-q32.1 · 1 E4|1 60.73 cM
Bgee
monocyte · appendix · blood · epithelium of nasopharynx · granulocyte
BioGPS
More reference expression data

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Clinical importance

Use as a congenic marker

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Map overview Semantic statistics

PTPRC

Nodes57
Edges56
Triples106
Avg. degree1.96
Density0.035088
Components1

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PTPRC

Top relations

Gene ontology · 43
PTPRC → B cell proliferation, B cell receptor signaling pathway, bone marrow development, cell cycle phase transition, cell surface, cell surface receptor signaling pathway, defense response to virus, dephosphorylation, external side of plasma membrane, extracellular exosome, focal adhesion, hematopoietic progenitor cell differentiation, hydrolase activity, integral component of membrane, integral component of plasma membrane, membrane, membrane raft, negative regulation of cell adhesion involved in substrate-bound cell migration, negative regulation of cytokine-mediated signaling pathway, negative regulation of protein kinase activity
Bgee · 16
PTPRC → appendix, blood, bone marrow, bone marrow cell, epithelium of nasopharynx, granulocyte, lymph node, mesenteric lymph nodes, monocyte, Paneth cell, right lung, spleen, stroma of bone marrow, submandibular gland, thymus, tibiofemoral joint
RNA expression pattern · 16
PTPRC → appendix, blood, bone marrow, bone marrow cell, epithelium of nasopharynx, granulocyte, lymph node, mesenteric lymph nodes, monocyte, Paneth cell, right lung, spleen, stroma of bone marrow, submandibular gland, thymus, tibiofemoral joint
is a · 3
PTPRC → critical enzyme involved in regulating immune cell function, enzyme that, transmembrane protein tyrosine phosphatase expressed on the surface of all nucleated hematopoietic cells
related to Interactions · 3
PTPRC → GANAB, Lck, LYN
Band · 2
PTPRC → 1 E4|1 60.73 cM, 1q31.3-q32.1
Chr. · 2
PTPRC → Chromosome 1 (human), Chromosome 1 (mouse)
End · 2
PTPRC → 138,103,446 bp, 198,757,476 bp
3.1.3.48 · 1
PTPRC → ↗
Aliases · 1
PTPRC → PTPRC, B220, CD45, CD45R, GP180, L-CA, LCA, LY5, T200, protein tyrosine phosphatase, receptor type C, protein tyrosine phosphatase receptor type C

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Important terminology

cd45 protein cells tyrosine gene cell phosphatase receptor immune bp isoforms signaling human also mouse chr band known differentiation hematopoietic

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
PTPRC3.1.3.481.00infobox
PTPRCAliasesPTPRC, B220, CD45, CD45R, GP180, L-CA, LCA, LY5, T200, protein tyrosine phosphatase, receptor type C, protein tyrosine phosphatase receptor type C1.00infobox
PTPRCAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1YGU, 1YGR, 5FMV, 5FN6, 5FN71.00infobox
PTPRCBand1q31.3-q32.11.00infobox
PTPRCBand1 E4|1 60.73 cM1.00infobox
PTPRCBgeemonocyte1.00infobox
PTPRCBgeeappendix1.00infobox
PTPRCBgeeblood1.00infobox
PTPRCBgeeepithelium of nasopharynx1.00infobox
PTPRCBgeegranulocyte1.00infobox
PTPRCBgeelymph node1.00infobox
PTPRCBgeebone marrow1.00infobox
PTPRCBgeebone marrow cell1.00infobox
PTPRCBgeethymus1.00infobox
PTPRCBgeespleen1.00infobox
PTPRCBgeetibiofemoral joint1.00infobox
PTPRCBgeestroma of bone marrow1.00infobox
PTPRCBgeesubmandibular gland1.00infobox
PTPRCBgeeright lung1.00infobox
PTPRCBgeePaneth cell1.00infobox
PTPRCBgeemesenteric lymph nodes1.00infobox
PTPRCBioGPSMore reference expression data1.00infobox
PTPRCChr.Chromosome 1 (human)1.00infobox
PTPRCChr.Chromosome 1 (mouse)1.00infobox
PTPRCDatabasesNCBI: entry; OMA: entry1.00infobox
PTPRCEnd198,757,476 bp1.00infobox
PTPRCEnd138,103,446 bp1.00infobox
PTPRCEnsemblENSG00000081237 ENSG000002624181.00infobox
PTPRCEntrez57881.00infobox
PTPRCEnzyme activityEnzyme activityEC #BRENDAExPASyKEGGMetaCyc3.1.3.48↗↗↗↗1.00infobox

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