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ARHGAP11B

ARHGAP11B is a human-specific gene that amplifies basal progenitors, controls neural progenitor proliferation, and contributes to neocortex folding. It is capable of causing neocortex folding in mice. This likely reflects a role for ARHGAP11B in development and evolutionary expansion of the human neocortex, a conclusion consistent with the finding that…

Function, Human evolution & Structure

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Aliases
ARHGAP11B, B'-T, FAM7B1, Rho GTPase activating protein 11B, GAP (1-8), ArhGAP11B and human encephalisation
Band
15q13.2
Bgee
testicle · bone marrow · bone marrow cell · ganglionic eminence · stromal cell of endometrium
BioGPS
n/a
Chr.
Chromosome 15 (human)
Databases
NCBI: entry; OMA: entry

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Overview

Structure

Activity

Function

Human evolution

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Map overview Semantic statistics

ARHGAP11B

Nodes27
Edges26
Triples64
Avg. degree1.93
Density0.074074
Components1

How this topic connects Entity context

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ARHGAP11B

Top relations

Bgee · 10
ARHGAP11B → appendix, bone marrow, bone marrow cell, ganglionic eminence, gonad, lymph node, monocyte, stromal cell of endometrium, testicle, ventricular zone
RNA expression pattern · 10
ARHGAP11B → appendix, bone marrow, bone marrow cell, ganglionic eminence, gonad, lymph node, monocyte, stromal cell of endometrium, testicle, ventricular zone
related to Activity · 7
ARHGAP11B → ARHGAP11A, ARHGAP11A1-220, C-terminal, In, RhoA/Rho-kinase, RhoGAP, This
Gene ontology · 6
ARHGAP11B → cerebral cortex development, cytosol, GTPase activator activity, positive regulation of GTPase activity, regulation of small GTPase mediated signal transduction, signal transduction
related to Function · 5
ARHGAP11B → Furthermore, It, Rho, RhoGAP, Several
related to Structure · 5
ARHGAP11B → ARHGAP11A, C-terminal, GAP, Rho GTPase-activating-protein, RhoGAP
related to Human evolution · 3
ARHGAP11B → Changes, Neanderthals, This
is a · 2
ARHGAP11B → gene responsible for the development of the neocortex during human evolution, human-specific gene that amplifies basal progenitors
Aliases · 1
ARHGAP11B → ARHGAP11B, B'-T, FAM7B1, Rho GTPase activating protein 11B, GAP (1-8), ArhGAP11B and human encephalisation
Band · 1
ARHGAP11B → 15q13.2

Important terminology Word statistics

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Important terminology

neocortex human gene activity bp arhgap11a rhogap folding development chr chromosome 15 function likely expansion evolution band rho nucleotide evolutionary

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
ARHGAP11BAliasesARHGAP11B, B'-T, FAM7B1, Rho GTPase activating protein 11B, GAP (1-8), ArhGAP11B and human encephalisation1.00infobox
ARHGAP11BBand15q13.21.00infobox
ARHGAP11BBgeetesticle1.00infobox
ARHGAP11BBgeebone marrow1.00infobox
ARHGAP11BBgeebone marrow cell1.00infobox
ARHGAP11BBgeeganglionic eminence1.00infobox
ARHGAP11BBgeestromal cell of endometrium1.00infobox
ARHGAP11BBgeeventricular zone1.00infobox
ARHGAP11BBgeegonad1.00infobox
ARHGAP11BBgeelymph node1.00infobox
ARHGAP11BBgeemonocyte1.00infobox
ARHGAP11BBgeeappendix1.00infobox
ARHGAP11BBioGPSn/a1.00infobox
ARHGAP11BChr.Chromosome 15 (human)1.00infobox
ARHGAP11BDatabasesNCBI: entry; OMA: entry1.00infobox
ARHGAP11BEnd30,649,529 bp1.00infobox
ARHGAP11BEnsemblENSG00000274734 ENSG00000286139 ENSG000002850771.00infobox
ARHGAP11BEntrez898391.00infobox
ARHGAP11BExternal IDsOMIM: 616310; GeneCards: ARHGAP11B1.00infobox
ARHGAP11BGene location (Human)Gene location (Human)Chr.Chromosome 15 (human)Band15q13.2Start30,624,494 bpEnd30,649,529 bp1.00infobox
ARHGAP11BGene ontologyGTPase activator activity1.00infobox
ARHGAP11BGene ontologycytosol1.00infobox
ARHGAP11BGene ontologyregulation of small GTPase mediated signal transduction1.00infobox
ARHGAP11BGene ontologysignal transduction1.00infobox
ARHGAP11BGene ontologycerebral cortex development1.00infobox
ARHGAP11BGene ontologypositive regulation of GTPase activity1.00infobox
ARHGAP11BLocation (UCSC)Chr 15: 30.62 – 30.65 Mb1.00infobox
ARHGAP11BOrthologsOrthologsDatabasesNCBI: entry; OMA: entrySpeciesHumanMouseEntrez89839n/aEnsemblENSG00000274734 ENSG00000286139 ENSG00000285077n/aUniProtQ3KRB8n/aRefSeq (mRNA)NM_001039841n/aRefS…1.00infobox
ARHGAP11BRefSeq (mRNA)NM_0010398411.00infobox
ARHGAP11BRefSeq (protein)NP_0010349301.00infobox

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