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Alpha-2B adrenergic receptor

The alpha-2B adrenergic receptor (α2B adrenoceptor), is a G-protein coupled receptor. It is a subtype of the adrenergic receptor family. The human gene encoding this receptor has the symbol ADRA2B. ADRA2B orthologs have been identified in several mammals.

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Aliases
ADRA2B, ADRA2L1, ADRA2RL1, ADRARL1, ALPHA2BAR, alpha-2BAR, FAME2, adrenoceptor alpha 2B
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2CVA
Band
2q11.2 · 2 F1|2 61.95 cM
Bgee
apex of heart · gastrocnemius muscle · left ventricle · right lobe of liver · spleen
BioGPS
n/a
Chr.
Chromosome 2 (human) · Chromosome 2 (mouse)

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Receptor

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Alpha-2B adrenergic receptor

Nodes37
Edges36
Triples92
Avg. degree1.95
Density0.054054
Components1

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Alpha-2B adrenergic receptor

Top relations

Gene ontology · 31
Alpha-2B adrenergic receptor → activation of protein kinase B activity, adenylate cyclase-activating adrenergic receptor signaling pathway, adenylate cyclase-modulating G protein-coupled receptor signaling pathway, adrenergic receptor activity, adrenergic receptor signaling pathway, alpha2-adrenergic receptor activity, cell surface, cell-cell signaling, epinephrine binding, female pregnancy, G protein-coupled receptor activity, G protein-coupled receptor signaling pathway, integral component of membrane, integral component of plasma membrane, intracellular anatomical structure, membrane, negative regulation of epinephrine secretion, negative regulation of norepinephrine secretion, plasma membrane, platelet activation
Bgee · 19
Alpha-2B adrenergic receptor → apex of heart, ascending aorta, decidua, embryo, gastric mucosa, gastrocnemius muscle, hepatobiliary system, human kidney, left ventricle, liver, muscle of thigh, proximal tubule, right kidney, right lobe of liver, secondary oocyte, spleen, subcutaneous adipose tissue, tibial nerve, yolk sac
RNA expression pattern · 19
Alpha-2B adrenergic receptor → apex of heart, ascending aorta, decidua, embryo, gastric mucosa, gastrocnemius muscle, hepatobiliary system, human kidney, left ventricle, liver, muscle of thigh, proximal tubule, right kidney, right lobe of liver, secondary oocyte, spleen, subcutaneous adipose tissue, tibial nerve, yolk sac
Band · 2
Alpha-2B adrenergic receptor → 2 F1|2 61.95 cM, 2q11.2
Chr. · 2
Alpha-2B adrenergic receptor → Chromosome 2 (human), Chromosome 2 (mouse)
End · 2
Alpha-2B adrenergic receptor → 127,209,141 bp, 96,116,571 bp
Aliases · 1
Alpha-2B adrenergic receptor → ADRA2B, ADRA2L1, ADRA2RL1, ADRARL1, ALPHA2BAR, alpha-2BAR, FAME2, adrenoceptor alpha 2B
Available structures · 1
Alpha-2B adrenergic receptor → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2CVA
BioGPS · 1
Alpha-2B adrenergic receptor → n/a
Databases · 1
Alpha-2B adrenergic receptor → NCBI: entry; OMA: entry

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Important terminology

gene receptor adra2b human bp adrenergic chr band α2b chromosome location also orthologs variant subtype mouse mammals protein adrenoceptor external

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Alpha-2B adrenergic receptorAliasesADRA2B, ADRA2L1, ADRA2RL1, ADRARL1, ALPHA2BAR, alpha-2BAR, FAME2, adrenoceptor alpha 2B1.00infobox
Alpha-2B adrenergic receptorAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2CVA1.00infobox
Alpha-2B adrenergic receptorBand2q11.21.00infobox
Alpha-2B adrenergic receptorBand2 F1|2 61.95 cM1.00infobox
Alpha-2B adrenergic receptorBgeeapex of heart1.00infobox
Alpha-2B adrenergic receptorBgeegastrocnemius muscle1.00infobox
Alpha-2B adrenergic receptorBgeeleft ventricle1.00infobox
Alpha-2B adrenergic receptorBgeeright lobe of liver1.00infobox
Alpha-2B adrenergic receptorBgeespleen1.00infobox
Alpha-2B adrenergic receptorBgeesubcutaneous adipose tissue1.00infobox
Alpha-2B adrenergic receptorBgeemuscle of thigh1.00infobox
Alpha-2B adrenergic receptorBgeetibial nerve1.00infobox
Alpha-2B adrenergic receptorBgeeascending aorta1.00infobox
Alpha-2B adrenergic receptorBgeegastric mucosa1.00infobox
Alpha-2B adrenergic receptorBgeeright kidney1.00infobox
Alpha-2B adrenergic receptorBgeeproximal tubule1.00infobox
Alpha-2B adrenergic receptorBgeehuman kidney1.00infobox
Alpha-2B adrenergic receptorBgeeyolk sac1.00infobox
Alpha-2B adrenergic receptorBgeedecidua1.00infobox
Alpha-2B adrenergic receptorBgeeembryo1.00infobox
Alpha-2B adrenergic receptorBgeehepatobiliary system1.00infobox
Alpha-2B adrenergic receptorBgeeliver1.00infobox
Alpha-2B adrenergic receptorBgeesecondary oocyte1.00infobox
Alpha-2B adrenergic receptorBioGPSn/a1.00infobox
Alpha-2B adrenergic receptorChr.Chromosome 2 (human)1.00infobox
Alpha-2B adrenergic receptorChr.Chromosome 2 (mouse)1.00infobox
Alpha-2B adrenergic receptorDatabasesNCBI: entry; OMA: entry1.00infobox
Alpha-2B adrenergic receptorEnd96,116,571 bp1.00infobox
Alpha-2B adrenergic receptorEnd127,209,141 bp1.00infobox
Alpha-2B adrenergic receptorEnsemblENSG000002742861.00infobox

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