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ADCY2

Adenylyl cyclase type 2 is an enzyme typically expressed in the brain of humans, that is encoded by the ADCY2 gene. It belongs to the adenylyl cyclase class-3 or guanylyl cyclase family because it contains two guanylate cyclase domains. ADCY2 is one of ten different mammalian isoforms of adenylyl cyclases. ADCY2 can be found on chromosome 5 and the…

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Clinical significance

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Function

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Structure

1 related topics

Overview

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4.6.1.1
Aliases
ADCY2, AC2, HBAC2, adenylate cyclase 2 (brain), adenylate cyclase 2
Band
5p15.31 · 13 B3|13 35.55 cM
Bgee
middle temporal gyrus · Brodmann area 23 · dorsal motor nucleus of vagus nerve · Skeletal muscle tissue of rectus abdominis · entorhinal cortex
BioGPS
More reference expression data
Chr.
Chromosome 5 (human) · Chromosome 13 (mouse)

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Overview

Structure

Function

Clinical significance

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Map overview Semantic statistics

ADCY2

Nodes24
Edges23
Triples140
Avg. degree1.92
Density0.083333
Components1

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ADCY2

Top relations

Gene ontology · 35
ADCY2 → activation of adenylate cyclase activity, activation of protein kinase A activity, adenylate cyclase activity, adenylate cyclase binding, adenylate cyclase-activating G protein-coupled receptor signaling pathway, adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway, adenylate cyclase-modulating G protein-coupled receptor signaling pathway, ATP binding, cAMP biosynthetic process, cAMP-mediated signaling, cellular response to forskolin, cellular response to glucagon stimulus, cGMP biosynthetic process, cyclic nucleotide biosynthetic process, cytoplasm, dendrite, G protein-coupled receptor signaling pathway, guanylate cyclase activity, guanylate cyclase complex, soluble, integral component of membrane
Bgee · 20
ADCY2 → biceps brachii, Brodmann area 23, CA3 field, cingulate gyrus, deltoid muscle, digastric muscle, dorsal motor nucleus of vagus nerve, entorhinal cortex, extraocular muscle, middle temporal gyrus, muscle of thigh, postcentral gyrus, primary motor cortex, primary visual cortex, Region I of hippocampus proper, Skeletal muscle tissue of biceps brachii, Skeletal muscle tissue of rectus abdominis, sternocleidomastoid muscle, superior frontal gyrus, temporal muscle
RNA expression pattern · 20
ADCY2 → biceps brachii, Brodmann area 23, CA3 field, cingulate gyrus, deltoid muscle, digastric muscle, dorsal motor nucleus of vagus nerve, entorhinal cortex, extraocular muscle, middle temporal gyrus, muscle of thigh, postcentral gyrus, primary motor cortex, primary visual cortex, Region I of hippocampus proper, Skeletal muscle tissue of biceps brachii, Skeletal muscle tissue of rectus abdominis, sternocleidomastoid muscle, superior frontal gyrus, temporal muscle
related to Function · 16
ADCY2 → A-kinase-anchoring, AKAP, AKAP-anchored, ATP, Ca2, G-proteins, Gq-coupled, In, Once, PDE4, PKC, Raf, Recently, The, Therefore, This
related to Structure · 13
ADCY2 → ADCY1, C1, C2, C2a, HBA C1, In, N-terminus, Outside, Structurally, The, The C1a, Then, This
related to Clinical significance · 12
ADCY2 → Anthrax, COPD, During, IP3, NCALD, Perturbations, PKA, Polymorphisms, SCN7A, SPAG16, This, WDR60
Band · 2
ADCY2 → 13 B3|13 35.55 cM, 5p15.31
Chr. · 2
ADCY2 → Chromosome 13 (mouse), Chromosome 5 (human)
End · 2
ADCY2 → 69,147,660 bp, 7,830,081 bp
related to External links · 2
ADCY2 → Human ADCY2, UCSC Genome Browser

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Important terminology

human adenylyl cyclase gene bp chromosome protein chr band enzyme camp kinase brain location function cyclases expressed structure pathway domain

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
ADCY24.6.1.11.00infobox
ADCY2AliasesADCY2, AC2, HBAC2, adenylate cyclase 2 (brain), adenylate cyclase 21.00infobox
ADCY2Band5p15.311.00infobox
ADCY2Band13 B3|13 35.55 cM1.00infobox
ADCY2Bgeemiddle temporal gyrus1.00infobox
ADCY2BgeeBrodmann area 231.00infobox
ADCY2Bgeedorsal motor nucleus of vagus nerve1.00infobox
ADCY2BgeeSkeletal muscle tissue of rectus abdominis1.00infobox
ADCY2Bgeeentorhinal cortex1.00infobox
ADCY2Bgeepostcentral gyrus1.00infobox
ADCY2Bgeemuscle of thigh1.00infobox
ADCY2Bgeebiceps brachii1.00infobox
ADCY2Bgeedeltoid muscle1.00infobox
ADCY2BgeeSkeletal muscle tissue of biceps brachii1.00infobox
ADCY2Bgeeprimary motor cortex1.00infobox
ADCY2BgeeCA3 field1.00infobox
ADCY2Bgeecingulate gyrus1.00infobox
ADCY2Bgeedigastric muscle1.00infobox
ADCY2BgeeRegion I of hippocampus proper1.00infobox
ADCY2Bgeeprimary visual cortex1.00infobox
ADCY2Bgeetemporal muscle1.00infobox
ADCY2Bgeesuperior frontal gyrus1.00infobox
ADCY2Bgeeextraocular muscle1.00infobox
ADCY2Bgeesternocleidomastoid muscle1.00infobox
ADCY2BioGPSMore reference expression data1.00infobox
ADCY2Chr.Chromosome 5 (human)1.00infobox
ADCY2Chr.Chromosome 13 (mouse)1.00infobox
ADCY2DatabasesNCBI: entry; OMA: entry1.00infobox
ADCY2End7,830,081 bp1.00infobox
ADCY2End69,147,660 bp1.00infobox

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