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ADAR

The double-stranded RNA-specific adenosine deaminase enzyme family are encoded by the ADAR family genes. ADAR stands for adenosine deaminase acting on RNA. This article focuses on the ADAR proteins; This article details the evolutionary history, structure, function, mechanisms and importance of all proteins within this family.

Art, Discovery & Evolution and function

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Discovery

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Evolution and function

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Catalytic activity

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Overview

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3.5.4.37
Aliases
ADAR, ADAR1, ADAR2, ADAR3, ADARB1, ADARB2, ADAR1p150, ADAR1p110, IFI-4, DSH, P136, adenosine deaminase RNA specific, DRADA, IFI4, AGS6, G1P1, K88DSRBP, DSRAD
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1QBJ, 1QGP, 1XMK, 2ACJ, 2GXB, 2L54, 2MDR, 3F21, 3F22, 3F23, 3IRQ, 3IRR
Band
1q21.3 · 3|3 F1
Bgee
endothelial cell · middle temporal gyrus · middle frontal gyrus · visceral pleura · parietal pleura
BioGPS
More reference expression data

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Overview

Discovery

Evolution and function

Forms of ADAR enzymes

Catalytic activity

Role in disease

Viral activity

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Map overview Semantic statistics

ADAR

Nodes68
Edges67
Triples252
Avg. degree1.97
Density0.029412
Components1

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ADAR

Top relations

Gene ontology · 44
ADAR → adenosine deaminase activity, adenosine to inosine editing, base conversion or substitution editing, cellular response to virus, cytoplasm, defense response to virus, definitive hemopoiesis, DNA binding, double-stranded RNA adenosine deaminase activity, double-stranded RNA binding, erythrocyte differentiation, gene silencing, hematopoietic progenitor cell differentiation, hematopoietic stem cell homeostasis, hydrolase activity, immune system process, in utero embryonic development, innate immune response, membrane, metal ion binding
Bgee · 20
ADAR → anterior amygdaloid area, arcuate nucleus, Brodmann area 23, dorsal tegmental nucleus, dorsomedial hypothalamic nucleus, endothelial cell, internal globus pallidus, lateral hypothalamus, mammillary body, middle frontal gyrus, middle temporal gyrus, palpebral conjunctiva, paraflocculus of cerebellum, paraventricular nucleus of hypothalamus, parietal pleura, subiculum, thymus, ventral tegmental area, ventromedial nucleus, visceral pleura
RNA expression pattern · 20
ADAR → anterior amygdaloid area, arcuate nucleus, Brodmann area 23, dorsal tegmental nucleus, dorsomedial hypothalamic nucleus, endothelial cell, internal globus pallidus, lateral hypothalamus, mammillary body, middle frontal gyrus, middle temporal gyrus, palpebral conjunctiva, paraflocculus of cerebellum, paraventricular nucleus of hypothalamus, parietal pleura, subiculum, thymus, ventral tegmental area, ventromedial nucleus, visceral pleura
related to Discovery · 18
ADAR → ATP, Bass, Brenda Bass, Finally, Harold Weintraub, However, In, It, Previous, Richard Wagner, RNA, The ADAR, These, They, This, To, Weintraub, Xenopus
related to Active site · 15
ADAR → ADAR1, ADAR2, ADAR3, C451, C516, E396, H394, In, IP6, RNA, The, Within, Z-DNA, Zα, Zβ
related to Aicardi–Goutières syndrome and bilateral striatal necrosis/dystonia · 15
ADAR → ADAR1, Aicardi, Bilateral Striatal Necrosis/Dystonia, Goutières, IFN, IFN-α, In, Mutation, P193A, RNA, The, This, Z-DNA, Z-RNA, Zα
related to ADAR (ADAR1) and ADAR2 (ADARB1) · 12
ADAR → ADAR1, ADAR1p110, ADAR1p150, ADAR2, ADARp110, Both, GluR-B, However, Q/R, R/G, RNA, These
related to Evolution and function · 11
ADAR → ADARs, ADAT, Adenosine Deaminase Acting, It, Metazoa, Recently, RNA, The, The ADAR, This, When
related to Dimerization · 10
ADAR → ADAR1, ADAR2, ADAR3, Earlier, However, In, RNA, RNA-binding, RNA-independent, This
related to Amyotrophic Lateral Sclerosis (ALS) · 9
ADAR → ADAR2, ALS, Ca2, Current, In, RNA-editing, TAR DNA-binding, TDP-43, When

Important terminology Word statistics

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Important terminology

rna adar1 adenosine editing protein inosine activity adar2 binding found proteins two gene also dsrna deaminase double-stranded genes human one

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
ADAR3.5.4.371.00infobox
ADARAliasesADAR, ADAR1, ADAR2, ADAR3, ADARB1, ADARB2, ADAR1p150, ADAR1p110, IFI-4, DSH, P136, adenosine deaminase RNA specific, DRADA, IFI4, AGS6, G1P1, K88DSRBP, DSRAD1.00infobox
ADARAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1QBJ, 1QGP, 1XMK, 2ACJ, 2GXB, 2L54, 2MDR, 3F21, 3F22, 3F23, 3IRQ, 3IRR1.00infobox
ADARBand1q21.31.00infobox
ADARBand3|3 F11.00infobox
ADARBgeeendothelial cell1.00infobox
ADARBgeemiddle temporal gyrus1.00infobox
ADARBgeemiddle frontal gyrus1.00infobox
ADARBgeevisceral pleura1.00infobox
ADARBgeeparietal pleura1.00infobox
ADARBgeepalpebral conjunctiva1.00infobox
ADARBgeethymus1.00infobox
ADARBgeeparaflocculus of cerebellum1.00infobox
ADARBgeeinternal globus pallidus1.00infobox
ADARBgeeBrodmann area 231.00infobox
ADARBgeedorsal tegmental nucleus1.00infobox
ADARBgeeparaventricular nucleus of hypothalamus1.00infobox
ADARBgeedorsomedial hypothalamic nucleus1.00infobox
ADARBgeeventral tegmental area1.00infobox
ADARBgeelateral hypothalamus1.00infobox
ADARBgeeventromedial nucleus1.00infobox
ADARBgeesubiculum1.00infobox
ADARBgeeanterior amygdaloid area1.00infobox
ADARBgeemammillary body1.00infobox
ADARBgeearcuate nucleus1.00infobox
ADARBioGPSMore reference expression data1.00infobox
ADARChr.Chromosome 1 (human)1.00infobox
ADARChr.Chromosome 3 (mouse)1.00infobox
ADARDatabasesNCBI: entry; OMA: entry1.00infobox
ADAREnd154,628,013 bp1.00infobox

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