ADAR

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ADAR topic overview

The analysis highlights Art, Discovery and Evolution and function as prominent areas in the source structure around ADAR.

Related topics: 60
Source areas: 7
Connected nodes: 67
Extracted relationships: 252
Concept neighborhoods: 20
Bridge connections: 67

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 17 topics

Catalytic activity · 10 topics

Discovery · 10 topics

Evolution and function · 10 topics

Role in disease · 6 topics

Viral activity · 5 topics

Forms of ADAR enzymes · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3.5.4.37: ↗
Aliases: ADAR, ADAR1, ADAR2, ADAR3, ADARB1, ADARB2, ADAR1p150, ADAR1p110, IFI-4, DSH, P136, adenosine deaminase RNA specific, DRADA, IFI4, AGS6, G1P1, K88DSRBP, DSRAD
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1QBJ, 1QGP, 1XMK, 2ACJ, 2GXB, 2L54, 2MDR, 3F21, 3F22, 3F23, 3IRQ, 3IRR
Band: 1q21.3 · 3|3 F1
Bgee: endothelial cell · middle temporal gyrus · middle frontal gyrus · visceral pleura · parietal pleura
BioGPS: More reference expression data

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Enzyme
Genes Gene
RNA
DsRNA
Adenosine
Inosine
Hypoxanthine
Deamination
Nucleotide
Guanine
Cytosine
Codon
Untranslated regions
Alu elements
Long interspersed nuclear elements Long interspersed nuclear element
Transcriptome
Hepatocellular carcinoma

Discovery

Evolution and function

Forms of ADAR enzymes

Catalytic activity

Role in disease

Aicardi–Goutières syndrome
Amyotrophic lateral sclerosis
TAR DNA-binding protein (TDP-43) TAR DNA-binding protein 43
Amino acid
Missense mutations Missense mutation
HIV

Viral activity

IFN Interferon
HCV Hepatitis C virus
LCMV Lymphocytic choriomeningitis
Polyomavirus Polyomaviridae
PKR Protein kinase R

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How ADAR connects Entity context

The extracted context around ADAR shows recurring relationship patterns in the source. For example, ADAR → adenosine deaminase activity, adenosine to inosine editing, base conversion or substitution editing, cellular response to virus, cytoplasm, defense response to virus, definitive hemopoiesis, DNA binding, double-stranded RNA adenosine deaminase activity, double-stranded RNA binding, erythrocyte differentiation, gene silencing, hematopoietic progenitor cell differentiation, hematopoietic stem cell homeostasis, hydrolase activity, immune system process, in utero embryonic development, innate immune response, membrane, metal ion binding Another extracted example is ADAR → anterior amygdaloid area, arcuate nucleus, Brodmann area 23, dorsal tegmental nucleus, dorsomedial hypothalamic nucleus, endothelial cell, internal globus pallidus, lateral hypothalamus, mammillary body, middle frontal gyrus, middle temporal gyrus, palpebral conjunctiva, paraflocculus of cerebellum, paraventricular nucleus of hypothalamus, parietal pleura, subiculum, thymus, ventral tegmental area, ventromedial nucleus, visceral pleura. Use these groups to spot repeated connection types before inspecting the individual relationships.

Top relations

Gene ontology · 44

ADAR → adenosine deaminase activity, adenosine to inosine editing, base conversion or substitution editing, cellular response to virus, cytoplasm, defense response to virus, definitive hemopoiesis, DNA binding, double-stranded RNA adenosine deaminase activity, double-stranded RNA binding, erythrocyte differentiation, gene silencing, hematopoietic progenitor cell differentiation, hematopoietic stem cell homeostasis, hydrolase activity, immune system process, in utero embryonic development, innate immune response, membrane, metal ion binding

Bgee · 20

ADAR → anterior amygdaloid area, arcuate nucleus, Brodmann area 23, dorsal tegmental nucleus, dorsomedial hypothalamic nucleus, endothelial cell, internal globus pallidus, lateral hypothalamus, mammillary body, middle frontal gyrus, middle temporal gyrus, palpebral conjunctiva, paraflocculus of cerebellum, paraventricular nucleus of hypothalamus, parietal pleura, subiculum, thymus, ventral tegmental area, ventromedial nucleus, visceral pleura

RNA expression pattern · 20

related to Discovery · 18

ADAR → ATP, Bass, Brenda Bass, Finally, Harold Weintraub, However, In, It, Previous, Richard Wagner, RNA, The ADAR, These, They, This, To, Weintraub, Xenopus

related to Active site · 15

ADAR → ADAR1, ADAR2, ADAR3, C451, C516, E396, H394, In, IP6, RNA, The, Within, Z-DNA, Zα, Zβ

related to Aicardi–Goutières syndrome and bilateral striatal necrosis/dystonia · 15

ADAR → ADAR1, Aicardi, Bilateral Striatal Necrosis/Dystonia, Goutières, IFN, IFN-α, In, Mutation, P193A, RNA, The, This, Z-DNA, Z-RNA, Zα

related to ADAR (ADAR1) and ADAR2 (ADARB1) · 12

ADAR → ADAR1, ADAR1p110, ADAR1p150, ADAR2, ADARp110, Both, GluR-B, However, Q/R, R/G, RNA, These

related to Evolution and function · 11

ADAR → ADARs, ADAT, Adenosine Deaminase Acting, It, Metazoa, Recently, RNA, The, The ADAR, This, When

related to Dimerization · 10

ADAR → ADAR1, ADAR2, ADAR3, Earlier, However, In, RNA, RNA-binding, RNA-independent, This

related to Amyotrophic Lateral Sclerosis (ALS) · 9

ADAR → ADAR2, ALS, Ca2, Current, In, RNA-editing, TAR DNA-binding, TDP-43, When

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

rna adar1 adenosine editing protein inosine activity adar2 binding found proteins two gene also dsrna deaminase double-stranded genes human one

ADAR relationships Subject–Predicate–Object triples

TTTA extracted 252 structured relationships around ADAR. Examples in this analysis include ADAR → 3.5.4.37 → ↗ and ADAR → Aliases → ADAR, ADAR1, ADAR2, ADAR3, ADARB1, ADARB2, ADAR1p150, ADAR1p110, IFI-4, DSH, P136, adenosine deaminase RNA specific, DRADA, IFI4, AGS6, G1P1, K88DSRBP, DSRAD. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
ADAR	3.5.4.37	↗	1.00	infobox
ADAR	Aliases	ADAR, ADAR1, ADAR2, ADAR3, ADARB1, ADARB2, ADAR1p150, ADAR1p110, IFI-4, DSH, P136, adenosine deaminase RNA specific, DRADA, IFI4, AGS6, G1P1, K88DSRBP, DSRAD	1.00	infobox
ADAR	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1QBJ, 1QGP, 1XMK, 2ACJ, 2GXB, 2L54, 2MDR, 3F21, 3F22, 3F23, 3IRQ, 3IRR	1.00	infobox
ADAR	Band	1q21.3	1.00	infobox
ADAR	Band	3\|3 F1	1.00	infobox
ADAR	Bgee	endothelial cell	1.00	infobox
ADAR	Bgee	middle temporal gyrus	1.00	infobox
ADAR	Bgee	middle frontal gyrus	1.00	infobox
ADAR	Bgee	visceral pleura	1.00	infobox
ADAR	Bgee	parietal pleura	1.00	infobox
ADAR	Bgee	palpebral conjunctiva	1.00	infobox
ADAR	Bgee	thymus	1.00	infobox
ADAR	Bgee	paraflocculus of cerebellum	1.00	infobox
ADAR	Bgee	internal globus pallidus	1.00	infobox
ADAR	Bgee	Brodmann area 23	1.00	infobox
ADAR	Bgee	dorsal tegmental nucleus	1.00	infobox
ADAR	Bgee	paraventricular nucleus of hypothalamus	1.00	infobox
ADAR	Bgee	dorsomedial hypothalamic nucleus	1.00	infobox
ADAR	Bgee	ventral tegmental area	1.00	infobox
ADAR	Bgee	lateral hypothalamus	1.00	infobox
ADAR	Bgee	ventromedial nucleus	1.00	infobox
ADAR	Bgee	subiculum	1.00	infobox
ADAR	Bgee	anterior amygdaloid area	1.00	infobox
ADAR	Bgee	mammillary body	1.00	infobox
ADAR	Bgee	arcuate nucleus	1.00	infobox
ADAR	BioGPS	More reference expression data	1.00	infobox
ADAR	Chr.	Chromosome 1 (human)	1.00	infobox
ADAR	Chr.	Chromosome 3 (mouse)	1.00	infobox
ADAR	Databases	NCBI: entry; OMA: entry	1.00	infobox
ADAR	End	154,628,013 bp	1.00	infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around ADAR bring nearby vocabulary together. In this analysis, examples include Deaminase, Rna and Two. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

ADAR
- Deaminase
- Rna
- Two
- Adenosine
- Enzymes
- Gene
- Binding
- Human
- Double-stranded
- Also
- Proteins
- Dsrna
adar
- Deaminase
- Rna
- Two
- Adenosine
- Enzymes
- Gene
- Binding
- Human
- Double-stranded
- Also
- Proteins
- Dsrna
enzyme
- Chromosome
- Lateral
- Bp
- Chr
- Function
- Human
- Gene
- Viral
- Adarb1
- Activity
- Band
- Forms
adenosine
- Deaminase
- Inosine
- Enzyme
- Reaction
- Double-stranded
- Viral
- Rna
- Adar
- Adarb1
- Chromosome
- Lateral
- Bp
binding domain
- Domain
- Deaminase
- Double-stranded
- Dsrna
- Rna
- Protein
- Enzymes
- Found
- Function
- Gene
- Inosine
- One
evolution and function
- Chromosome
- Lateral
- Bp
- Chr
- Human
- Gene
- Viral
- Also
- Binding
- Rna
- Activity
- Adarb1
forms of adar enzymes
- Adarb1
- Reaction
- Adar2
- Adar3
- Deaminase
- Rna
- Two
- Adenosine
- Enzymes
- Gene
- Dsrna
- Binding
catalytic activity
- Rna
- Editing
- Chromosome
- Enzyme
- Lateral
- Bp
- Chr
- Embryos
- Forms
- Research
- Function
- Human

Connections between topic areas Semantic bridges

For ADAR, one of the stronger structural bridges in this analysis connects ADAR with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

ADAR — Overview · splits 50 ⟂ 18

ADAR — Discovery · splits 57 ⟂ 11

ADAR — Evolution and function · splits 57 ⟂ 11

ADAR — Catalytic activity · splits 57 ⟂ 11

ADAR — Role in disease · splits 61 ⟂ 7

ADAR — Viral activity · splits 62 ⟂ 6

ADAR — Forms of ADAR enzymes · splits 65 ⟂ 3

Map overview Semantic statistics

ADAR

Nodes68

Edges67

Triples252

Avg. degree1.97

Density0.029412

Components1

Source & methodology

TTTA analyzes the structure around ADAR to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Art, Discovery & Evolution and function, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — ADAR · EN edition · Analysis: TopicsToTalkAbout