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Lamivudine

Lamivudine, commonly called 3TC, is an antiretroviral medication used to prevent and treat HIV/AIDS. It is also used to treat chronic hepatitis B when other options are not possible. It is effective against both HIV-1 and HIV-2. It is typically used in combination with other antiretrovirals such as zidovudine, dolutegravir, and abacavir. Lamivudine may…

History & Applications

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
J05AF05 (WHO)
Bioavailability
86%
CAS Number
134678-17-4 Y
ChEMBL
ChEMBL141 Y

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Overview

Medical uses

Resistance

Side effects

Mechanism of action

History

Formulations

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Map overview Semantic statistics

Lamivudine

Nodes73
Edges72
Triples123
Avg. degree1.97
Density0.027397
Components1

How this topic connects Entity context

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Lamivudine

Top relations

related to history · 22
Lamivudine → As, AZT, Bernard Belleau, DNA, Drug Administration, Essential Medicines, FDA, HIV, Inc, It, McGill University, Montreal-based IAF BioChem International, November, Paul Nguyen-Ba, Racemic BCH-189, Samples, The, US Food, When, World Health Organization's List
related to Resistance · 20
Lamivudine → Emory University, GlaxoSmithKline, GSK, HBV, HIV, In, In HIV, L180M, L80V/I, M184V, M184V/I, M204V/I/S, Other, Raymond Schinazi's, The, The COLATE, The HBV, V173L, YIDD, YMDD
related to Formulations · 17
Lamivudine → Abacavir/lamivudine, Abacavir/lamivudine/zidovudine, B3TC, BLamivudine, BZeffix, Dolutegravir/lamivudine, Doravirine/lamivudine/tenofovir, Epivir, GlaxoSmithKline, HIV, HIV3TC-HBV, HIVEpivir-HBV, Indonesia, Lamivudine/zidovudine, South Africa, UK, US
has effect · 15
Lamivudine → Autoimmune, CMV, Do, HBV-infected, HCV, HIV, Long-term, MAC, Minor, Mycobacterium, Patients, Pneumocystis, The, Use, YMDD
related to Medical uses · 8
Lamivudine → Despite, Epivir, Epivir HBV, HIV, HIV/AIDS, It, Long-term, YMDD
related to Mechanism of action · 7
Lamivudine → DNA, HIV, It, OH, Some, The, They
Legal status · 4
Lamivudine → CA: ℞-only, EU: Rx-only, UK: POM (Prescription only), US: ℞-only
3D model (JSmol) · 1
Lamivudine → Interactive image
AHFS/Drugs.com · 1
Lamivudine → Monograph
ATC code · 1
Lamivudine → J05AF05 (WHO)

Important terminology Word statistics

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Important terminology

hiv hepatitis used reverse transcriptase zidovudine side effects treatment virus resistance liver medication combination use viral include antiretroviral abacavir epivir

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Lamivudine3D model (JSmol)Interactive image1.00infobox
LamivudineAHFS/Drugs.comMonograph1.00infobox
LamivudineATC codeJ05AF05 (WHO)1.00infobox
LamivudineBioavailability86%1.00infobox
LamivudineCAS Number134678-17-4 Y1.00infobox
LamivudineChEMBLChEMBL141 Y1.00infobox
LamivudineChemSpider66068 Y1.00infobox
LamivudineCompTox Dashboard (EPA)DTXSID70231941.00infobox
LamivudineDrugBankDB00709 Y1.00infobox
LamivudineECHA InfoCard100.132.2501.00infobox
LamivudineElimination half-life5 to 7 hours1.00infobox
LamivudineExcretionKidney (circa 70%)1.00infobox
LamivudineFormulaC8H11N3O3S1.00infobox
LamivudineKEGGD00353 Y1.00infobox
LamivudineLegal statusCA: ℞-only1.00infobox
LamivudineLegal statusUK: POM (Prescription only)1.00infobox
LamivudineLegal statusUS: ℞-only1.00infobox
LamivudineLegal statusEU: Rx-only1.00infobox
LamivudineLicense dataUS DailyMed: Lamivudine1.00infobox
LamivudineMedlinePlusa6960111.00infobox
LamivudineMolar mass229.25 g·mol−11.00infobox
LamivudineNIAID ChemDB0003881.00infobox
LamivudineOther names(−)-L-2′,3′-dideoxy-3′-thiacytidine1.00infobox
LamivudinePDB ligand3TC (PDBe, RCSB PDB)1.00infobox
LamivudinePregnancy categoryAU: B31.00infobox
LamivudineProtein bindingLess than 36%1.00infobox
LamivudinePubChem CID608251.00infobox
LamivudineRoutes of administrationBy mouth1.00infobox
LamivudineTrade namesEpivir, Epivir-HBV, Zeffix, others1.00infobox
LamivudineUNII2T8Q726O951.00infobox

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