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Top-down proteomics

Top-down proteomics is a method of protein identification capable of identifying and quantitating unique proteoforms through the analysis of intact proteins. The name is derived from the similar approach to DNA sequencing. During mass spectrometry, intact proteoforms are typically ionized by electrospray ionization and analysed using a variety of mass…

Integrated Top-Down Proteomics (iTDP), Mass spectrometry-intensive TDP (MSi-TDP) & Overview

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Integrated Top-Down Proteomics (iTDP)

Isoelectric focusing SDS-PAGE Western blotting Isoelectric point Coomassie Brilliant Blue

6 related topics

Mass spectrometry-intensive TDP (MSi-TDP)

Collision-induced dissociation Electron-capture dissociation Electron-transfer dissociation Analyte Elution

6 related topics

Overview

Protein Proteoforms Electrospray ionization Orbitraps Ion Cyclotrons

15 related topics

Potential Future Directions

Edman degradation Nanopore sequencing

2 related topics

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Overview

Protein
Proteoforms Proteoform
Electrospray ionization
Orbitraps Orbitrap
Ion Cyclotrons Ion cyclotron resonance
Time-Of-Flight Time-of-flight mass spectrometry
Mass spectrometry
Bottom up Bottom-up proteomics
Protein structure
Alternative splicing
Open Reading Frame
Proteogenomic Proteogenomics
Two-dimensional gel electrophoresis
Liquid chromatography
Tandem mass spectrometry

Integrated Top-Down Proteomics (iTDP)

Mass spectrometry-intensive TDP (MSi-TDP)

Potential Future Directions

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Top-down proteomics

Nodes34

Edges33

Triples9

Avg. degree1.94

Density0.058824

Components1

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Top-down proteomics

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Top-down proteomics → method of protein identification capable of identifying and quantitating unique proteoforms through the analysis of intact proteins

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Important terminology

proteoforms analysis proteome proteoform protein ms intact thus msi-tdp analyses species also mass lc itdp proteomics approach approaches using gel

Entity relationships Subject–Predicate–Object triples

Subject	Predicate	Object	Confidence	Src
Top-down proteomics	is a	method of protein identification capable of identifying and quantitating unique proteoforms through the analysis of intact proteins	0.90	text
analyte clustering	instance of	the rate of identifying new proteins is sharply reduced after initial rounds.The effect of chemical noise stemming from various factors	0.80	text
multimers	instance of	the rate of identifying new proteins is sharply reduced after initial rounds.The effect of chemical noise stemming from various factors	0.80	text
or interfering species	instance of	the rate of identifying new proteins is sharply reduced after initial rounds.The effect of chemical noise stemming from various factors	0.80	text
further compounds the arduousness of intact proteofrom detection	instance of	the rate of identifying new proteins is sharply reduced after initial rounds.The effect of chemical noise stemming from various factors	0.80	text
analysis using MSi-TDP.The requirement to remove surfactants	instance of	the rate of identifying new proteins is sharply reduced after initial rounds.The effect of chemical noise stemming from various factors	0.80	text
specifically SDS as used in Gel Elution Liquid-based Fractionation Entrapment Electrophoresis fractionation	instance of	the rate of identifying new proteins is sharply reduced after initial rounds.The effect of chemical noise stemming from various factors	0.80	text
prior to LC means that some proteoforms will be lost due to a lack of solubility after surfactant removal	instance of	the rate of identifying new proteins is sharply reduced after initial rounds.The effect of chemical noise stemming from various factors	0.80	text
potential clogging of pores will also need to be addressed with hopefully routine solutions	instance of	Other technical issues	0.80	text

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