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Thyroid peroxidase

Thyroid peroxidase, also called thyroperoxidase (TPO), thyroid specific peroxidase or iodide peroxidase, is an enzyme expressed mainly in the thyroid where it is secreted into colloid. Thyroid peroxidase oxidizes iodide ions to form iodine atoms for addition onto tyrosine residues on thyroglobulin for the production of thyroxine (T4) or triiodothyronine…

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Catalyzed reaction

DehydroalanineHOIR-T3T2T1
5 related topics

Stimulation and inhibition

TSHThioamidePropylthiouracilMethimazoleGenistein
5 related topics

Clinical significance

EpitopeAutoantibodiesAnti-thyroid peroxidase antibodiesHashimoto's thyroiditisAntibody titer
5 related topics

Function

Thyroid folliclePendrinOxidizesEndostyle
4 related topics

Key facts & relationships

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BRENDA
enzyme data
CAS no.
9031-28-1
EC no.
1.11.1.8
ExPASy
NiceZyme view
Gene Ontology
AmiGO / QuickGO
KEGG
enzyme entry

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Overview

Function

Catalyzed reaction

Stimulation and inhibition

Clinical significance

Diagnostic use

Biotechnology

Advanced semantic analysis

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Map overview Semantic statistics

Thyroid peroxidase

Nodes40
Edges39
Triples32
Avg. degree1.95
Density0.05
Components1

How this topic connects Entity context

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Thyroid peroxidase

Top relations

related to Function · 10
Thyroid peroxidase → After, Ascidians, Inorganic, Na, NIS, Presumably, The, They, TPO, TPO-bound
related to Clinical significance · 5
Thyroid peroxidase → Hashimoto's, This, Thus, Thyroid, TPO
related to Diagnostic use · 2
Thyroid peroxidase → In, TPO
BRENDA · 1
Thyroid peroxidase → enzyme data
CAS no. · 1
Thyroid peroxidase → 9031-28-1
EC no. · 1
Thyroid peroxidase → 1.11.1.8
ExPASy · 1
Thyroid peroxidase → NiceZyme view
Gene Ontology · 1
Thyroid peroxidase → AmiGO / QuickGO
KEGG · 1
Thyroid peroxidase → enzyme entry
MetaCyc · 1
Thyroid peroxidase → metabolic pathway

Important terminology Word statistics

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Important terminology

tpo thyroid peroxidase iodide thyroglobulin reactions iodine gene enzyme also form residues t3 thyroperoxidase proteins reaction oxidizes tyrosine thyroxine protein

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Thyroid peroxidaseBRENDAenzyme data1.00infobox
Thyroid peroxidaseCAS no.9031-28-11.00infobox
Thyroid peroxidaseEC no.1.11.1.81.00infobox
Thyroid peroxidaseExPASyNiceZyme view1.00infobox
Thyroid peroxidaseGene OntologyAmiGO / QuickGO1.00infobox
Thyroid peroxidaseKEGGenzyme entry1.00infobox
Thyroid peroxidaseMetaCycmetabolic pathway1.00infobox
Thyroid peroxidaseNCBIproteins1.00infobox
Thyroid peroxidasePDB structuresRCSB PDB PDBe PDBsum1.00infobox
Thyroid peroxidasePMCarticles1.00infobox
Thyroid peroxidasePubMedarticles1.00infobox
Thyroid peroxidaseRheareactions1.00infobox
Thyroid peroxidaseSearchSearchPMCarticlesPubMedarticlesNCBIproteins1.00infobox

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