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Pendrin: Music, Overview & Function
Pendrin is an anion exchange protein that in humans is encoded by the SLC26A4 gene (solute carrier family 26, member 4). Pendrin was initially identified as a sodium-independent chloride-iodide exchanger with subsequent studies showing that it also accepts formate and bicarbonate as substrates. Pendrin is similar to the Band 3 transport protein found in…
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Pendrin topic overview
The analysis highlights Music, Overview and Function as prominent areas in the source structure around Pendrin.
Related topics
29
Source areas
3
Connected nodes
32
Extracted relationships
115
Concept neighborhoods
21
Bridge connections
32
What this topic covers Research coverage
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Overview · 19 topics
Function · 6 topics
Clinical significance · 4 topics
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
Key facts & relationships
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Aliases
SLC26A4, DFNB4, EVA, PDS, TDH2B, solute carrier family 26 member 4
Band
7q22.3 · 12|12 A2
Bgee
palpebral conjunctiva · right lobe of thyroid gland · left lobe of thyroid gland · Achilles tendon · Brodmann area 23
BioGPS
More reference expression data
Chr.
Chromosome 7 (human) · Chromosome 12 (mouse)
Databases
NCBI: entry; OMA: entry
Explore all related topics Closing gaps
A structured outline of related entities, concepts and subtopics. Open any item to build a new map centered on it.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
How Pendrin connects Entity context
Entity context groups extracted connections by relationship type. Counts show recurrence in the analyzed source; the examples are research signals, not claims about importance.
The extracted context around Pendrin shows recurring relationship patterns in the source. For example, Pendrin → anion transmembrane transport, apical plasma membrane, bicarbonate transmembrane transporter activity, bicarbonate transport, brush border membrane, chloride channel activity, chloride transmembrane transport, chloride transmembrane transporter activity, chloride transport, extracellular exosome, hearing, inorganic anion transport, integral component of membrane, integral component of plasma membrane, iodide transmembrane transporter activity, iodide transport, ion transport, membrane, oxalate transmembrane transporter activity, oxalate transport Another extracted example is Pendrin → Achilles tendon, Brodmann area 23, ciliary body, cochlea, connecting tubule, glomerulus, human kidney, iris, kidney tubule, left lobe of thyroid gland, middle temporal gyrus, nasal epithelium, palpebral conjunctiva, right kidney, right lobe of thyroid gland, stria vascularis, testicle, utricle, vestibular membrane of cochlear duct, vestibular sensory epithelium. Use these groups to spot repeated connection types before inspecting the individual relationships.
Pendrin
Top relations
Gene ontology· 31
Pendrin → anion transmembrane transport, apical plasma membrane, bicarbonate transmembrane transporter activity, bicarbonate transport, brush border membrane, chloride channel activity, chloride transmembrane transport, chloride transmembrane transporter activity, chloride transport, extracellular exosome, hearing, inorganic anion transport, integral component of membrane, integral component of plasma membrane, iodide transmembrane transporter activity, iodide transport, ion transport, membrane, oxalate transmembrane transporter activity, oxalate transport
Bgee· 20
Pendrin → Achilles tendon, Brodmann area 23, ciliary body, cochlea, connecting tubule, glomerulus, human kidney, iris, kidney tubule, left lobe of thyroid gland, middle temporal gyrus, nasal epithelium, palpebral conjunctiva, right kidney, right lobe of thyroid gland, stria vascularis, testicle, utricle, vestibular membrane of cochlear duct, vestibular sensory epithelium
RNA expression pattern· 20
Pendrin → Achilles tendon, Brodmann area 23, ciliary body, cochlea, connecting tubule, glomerulus, human kidney, iris, kidney tubule, left lobe of thyroid gland, middle temporal gyrus, nasal epithelium, palpebral conjunctiva, right kidney, right lobe of thyroid gland, stria vascularis, testicle, utricle, vestibular membrane of cochlear duct, vestibular sensory epithelium
Relationships are represented as Subject → Predicate → Object triples. Confidence describes extraction strength, not the real-world importance of a relationship; lower-confidence rows may be contextual rather than explicit.
TTTA extracted 115 structured relationships around Pendrin. Examples in this analysis include Pendrin → Aliases → SLC26A4, DFNB4, EVA, PDS, TDH2B, solute carrier family 26 member 4 and Pendrin → Band → 7q22.3. The table shows each extracted connection, where it came from and its confidence.
Subject
Predicate
Object
Confidence
Src
Pendrin
Aliases
SLC26A4, DFNB4, EVA, PDS, TDH2B, solute carrier family 26 member 4
1.00
infobox
Pendrin
Band
7q22.3
1.00
infobox
Pendrin
Band
12|12 A2
1.00
infobox
Pendrin
Bgee
palpebral conjunctiva
1.00
infobox
Pendrin
Bgee
right lobe of thyroid gland
1.00
infobox
Pendrin
Bgee
left lobe of thyroid gland
1.00
infobox
Pendrin
Bgee
Achilles tendon
1.00
infobox
Pendrin
Bgee
Brodmann area 23
1.00
infobox
Pendrin
Bgee
kidney tubule
1.00
infobox
Pendrin
Bgee
nasal epithelium
1.00
infobox
Pendrin
Bgee
glomerulus
1.00
infobox
Pendrin
Bgee
testicle
1.00
infobox
Pendrin
Bgee
middle temporal gyrus
1.00
infobox
Pendrin
Bgee
ciliary body
1.00
infobox
Pendrin
Bgee
vestibular membrane of cochlear duct
1.00
infobox
Pendrin
Bgee
iris
1.00
infobox
Pendrin
Bgee
utricle
1.00
infobox
Pendrin
Bgee
vestibular sensory epithelium
1.00
infobox
Pendrin
Bgee
right kidney
1.00
infobox
Pendrin
Bgee
human kidney
1.00
infobox
Pendrin
Bgee
cochlea
1.00
infobox
Pendrin
Bgee
stria vascularis
1.00
infobox
Pendrin
Bgee
connecting tubule
1.00
infobox
Pendrin
BioGPS
More reference expression data
1.00
infobox
Pendrin
Chr.
Chromosome 7 (human)
1.00
infobox
Pendrin
Chr.
Chromosome 12 (mouse)
1.00
infobox
Pendrin
Databases
NCBI: entry; OMA: entry
1.00
infobox
Pendrin
End
107,717,809 bp
1.00
infobox
Pendrin
End
31,609,968 bp
1.00
infobox
Pendrin
Ensembl
ENSG00000091137
1.00
infobox
No triples extracted yet.
Related concept clusters Concept neighborhoods
Concept neighborhoods group terms that sit near one another in the extracted graph. They are useful for discovering adjacent language and context, but proximity does not by itself imply a factual relationship.
The concept neighborhoods around Pendrin bring nearby vocabulary together. In this analysis, examples include Cells, Bicarbonate and Membrane. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
Pendrin
Cells
Bicarbonate
Membrane
Apical
Expression
Protein
Thyroid
Chloride
Duct
Exchanger
Found
Hco3
pendrin
Cells
Bicarbonate
Membrane
Apical
Expression
Protein
Thyroid
Chloride
Duct
Exchanger
Found
Hco3
anion exchange
Hco3
Slc26a4
Carrier
Family
Gene
Hearing
Membrane
Mouse
Orthologs
Protein
Solute
Transport
protein
Slc26a4
Hearing
Transport
Found
Pendred
Syndrome
Band
Human
Cells
Mouse
Orthologs
Solute
gene
Slc26a4
Location
Chromosome
Bp
Chr
Human
Carrier
Family
Mouse
Solute
Function
Band
bicarbonate
Chloride
Kidney
Membrane
Orthologs
Duct
Exchanger
Cells
Apical
Expressed
Expression
Function
Pendrin
band 3
Bp
Chr
Chromosome
Human
Mouse
Transport
Found
Location
Gene
Protein
Cells
Hearing
transport protein
Found
Band
Slc26a4
Anion
Hearing
Mouse
Orthologs
Protein
Transport
Cells
Chloride
Duct
Connections between topic areas Semantic bridges
Semantic bridges connect parts of the graph that would otherwise be more separate. A bridge is a structural signal in this analysis, not a claim that the two topic areas are equivalent.
For Pendrin, one of the stronger structural bridges in this analysis connects Pendrin with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
Number of nodes, edges, triples, density and central hubs. Use it to gauge the size and connectivity of the map.
Pendrin
Nodes33
Edges32
Triples115
Avg. degree1.94
Density0.060606
Components1
Source & methodology
TTTA analyzes the structure around Pendrin to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Music, Overview & Function, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
