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Thermogenin: History, Mechanism & Evolution

Thermogenin (called uncoupling protein by its discoverers and now known as uncoupling protein 1, or UCP1) is a mitochondrial carrier protein found in brown adipose tissue (BAT). It is used to generate heat by non-shivering thermogenesis, and makes a quantitatively important contribution to countering heat loss in babies which would otherwise occur due to…

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Thermogenin topic overview

The analysis highlights History, Mechanism and Evolution as prominent areas in the source structure around Thermogenin.

Related topics
45
Source areas
5
Connected nodes
50
Extracted relationships
105
Related term clusters
18
Bridge connections
50

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Mechanism · 20 topics
Evolution · 15 topics
History · 5 topics
Overview · 4 topics
Structure · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
UCP1, SLC25A7, UCP, uncoupling protein 1
Band
4q31.1 · 8 C2|8 39.65 cM
Bgee
testicle · parietal pleura · face · mucosa of nose · Ventricular system of neuraxis
BioGPS
More reference expression data
Chr.
Chromosome 4 (human) · Chromosome 8 (mouse)
Databases
NCBI: entry; OMA: entry

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Thermogenin
4Uncoupling protein · Mitochondrial carrier · Brown adipose tissue
3Mitochondrial inner membrane · Intermembrane space · Mitochondrial matrix
9Norepinephrine · Beta-3 adrenergic receptor · Plasma membrane

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Mechanism

Evolution

History

For the semantics nerds

You can skip this section if you’re here for content ideas and keyword inspiration.

Advanced semantic analysis

How Thermogenin connects Entity context

The extracted context around Thermogenin shows recurring relationship patterns in the source. For example, Thermogenin → adaptive thermogenesis, brown fat cell differentiation, cardiolipin binding, cellular response to fatty acid, cellular response to hormone stimulus, cellular response to reactive oxygen species, diet induced thermogenesis, integral component of membrane, ion transport, long-chain fatty acid binding, membrane, mitochondrial envelope, mitochondrial inner membrane, mitochondrial membranes, mitochondrial transmembrane transport, mitochondrial transport, mitochondrion, oxidative phosphorylation uncoupler activity, positive regulation of cold-induced thermogenesis, proton transmembrane transport Another extracted example is Thermogenin → ascending aorta, brown adipose tissue, carotid body, face, intercostal muscle, lactiferous gland, mammary gland, mucosa of nose, olfactory zone of nasal mucosa, parietal pleura, parotid gland, placenta, sternocleidomastoid muscle, superior surface of tongue, testicle, trachea, tunica adventitia of aorta, tunica media of zone of aorta, Ventricular system of neuraxis, ventricular zone. Use these groups to spot repeated connection types before inspecting the individual relationships.

Thermogenin

Top relations

Gene ontology · 27
Thermogenin → adaptive thermogenesis, brown fat cell differentiation, cardiolipin binding, cellular response to fatty acid, cellular response to hormone stimulus, cellular response to reactive oxygen species, diet induced thermogenesis, integral component of membrane, ion transport, long-chain fatty acid binding, membrane, mitochondrial envelope, mitochondrial inner membrane, mitochondrial membranes, mitochondrial transmembrane transport, mitochondrial transport, mitochondrion, oxidative phosphorylation uncoupler activity, positive regulation of cold-induced thermogenesis, proton transmembrane transport
Bgee · 20
Thermogenin → ascending aorta, brown adipose tissue, carotid body, face, intercostal muscle, lactiferous gland, mammary gland, mucosa of nose, olfactory zone of nasal mucosa, parietal pleura, parotid gland, placenta, sternocleidomastoid muscle, superior surface of tongue, testicle, trachea, tunica adventitia of aorta, tunica media of zone of aorta, Ventricular system of neuraxis, ventricular zone
RNA expression pattern · 20
Thermogenin → ascending aorta, brown adipose tissue, carotid body, face, intercostal muscle, lactiferous gland, mammary gland, mucosa of nose, olfactory zone of nasal mucosa, parietal pleura, parotid gland, placenta, sternocleidomastoid muscle, superior surface of tongue, testicle, trachea, tunica adventitia of aorta, tunica media of zone of aorta, Ventricular system of neuraxis, ventricular zone
related to Mechanism · 12
Thermogenin → Active, ADP, AMP, ATP, Beta-3, Fatty, GDP, Norepinephrine, Sympathetic, UCP, UCP1, UCP1-mediated
related to Evolution · 4
Thermogenin → Recent, The UCP1, UCP1, While UCP1
Band · 2
Thermogenin → 4q31.1, 8 C2|8 39.65 cM
Chr. · 2
Thermogenin → Chromosome 4 (human), Chromosome 8 (mouse)
End · 2
Thermogenin → 140,568,961 bp, 84,025,081 bp
Aliases · 1
Thermogenin → UCP1, SLC25A7, UCP, uncoupling protein 1
BioGPS · 1
Thermogenin → More reference expression data

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

ucp1 protein brown bp membrane gene human thermogenesis uncoupling mitochondrial adipose tissue chr band proton heat chromosome fatty placental acids

Thermogenin relationships Subject–Predicate–Object triples

TTTA extracted 105 structured relationships around Thermogenin. Examples in this analysis include Thermogenin → Aliases → UCP1, SLC25A7, UCP, uncoupling protein 1 and Thermogenin → Band → 4q31.1. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
ThermogeninAliasesUCP1, SLC25A7, UCP, uncoupling protein 11.00infobox
ThermogeninBand4q31.11.00infobox
ThermogeninBand8 C2|8 39.65 cM1.00infobox
ThermogeninBgeetesticle1.00infobox
ThermogeninBgeeparietal pleura1.00infobox
ThermogeninBgeeface1.00infobox
ThermogeninBgeemucosa of nose1.00infobox
ThermogeninBgeeVentricular system of neuraxis1.00infobox
ThermogeninBgeeplacenta1.00infobox
ThermogeninBgeeventricular zone1.00infobox
ThermogeninBgeeolfactory zone of nasal mucosa1.00infobox
ThermogeninBgeemammary gland1.00infobox
ThermogeninBgeelactiferous gland1.00infobox
ThermogeninBgeeintercostal muscle1.00infobox
ThermogeninBgeeparotid gland1.00infobox
ThermogeninBgeesuperior surface of tongue1.00infobox
ThermogeninBgeetunica adventitia of aorta1.00infobox
ThermogeninBgeetrachea1.00infobox
ThermogeninBgeebrown adipose tissue1.00infobox
ThermogeninBgeesternocleidomastoid muscle1.00infobox
ThermogeninBgeetunica media of zone of aorta1.00infobox
ThermogeninBgeecarotid body1.00infobox
ThermogeninBgeeascending aorta1.00infobox
ThermogeninBioGPSMore reference expression data1.00infobox
ThermogeninChr.Chromosome 4 (human)1.00infobox
ThermogeninChr.Chromosome 8 (mouse)1.00infobox
ThermogeninDatabasesNCBI: entry; OMA: entry1.00infobox
ThermogeninEnd140,568,961 bp1.00infobox
ThermogeninEnd84,025,081 bp1.00infobox
ThermogeninEnsemblENSG000001094241.00infobox

Related concept clusters Related term clusters

The concept neighborhoods around Thermogenin bring nearby vocabulary together. In this analysis, examples include Thermogenesis, Carrier and Cell. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • uncoupling protein
    • Protein
    • Uncoupling
    • Location
    • Structure
    • Carrier
    • Chromosome
    • Human
    • Ucp1
    • Bp
    • Chr
    • Adipose
    • Mitochondrial
  • mitochondrial carrier
    • Inner
    • Matrix
    • Membrane
    • Proton
    • Allowing
    • Protein
    • Adipose
    • Ant
    • Atp
    • Tissue
    • Uncoupling
    • Brown
  • brown adipose tissue
    • Tissue
    • Adipose
    • Brown
    • Found
    • Fat
    • Heat
    • Ucp1
    • Cell
    • Mitochondrial
    • Uncoupling
    • Fatty
    • Mouse
  • mitochondrial inner membrane
    • Inner
    • Matrix
    • Mitochondrial
    • Membrane
    • Proton
    • Allowing
    • Proteins
    • Substrate
    • Surface
    • Adipose
    • Mouse
    • Protein
  • mitochondrial matrix
    • Inner
    • Matrix
    • Mitochondrial
    • Membrane
    • Proton
    • Allowing
    • Adipose
    • Protein
    • Tissue
    • Uncoupling
    • Brown
    • Proteins
  • protein kinase a
    • Uncoupling
    • Carrier
    • Ucp1
    • Mitochondrial
    • Membrane
    • Atp
    • Location
    • Structure
    • Surface
    • Chromosome
    • Human
    • Bp
  • uncoupling protein two
    • Protein
    • Uncoupling
    • Location
    • Structure
    • Carrier
    • Chromosome
    • Human
    • Ucp1
    • Bp
    • Chr
    • Adipose
    • Mitochondrial
  • plasma membrane
    • Mitochondrial
    • Inner
    • Matrix
    • Proton
    • Proteins
    • Substrate
    • Surface
    • Allowing
    • Acids
    • Protein
    • Ucp1
    • Mouse

Connections between topic areas Semantic bridges

For Thermogenin, one of the stronger structural bridges in this analysis connects Thermogenin with Mechanism. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Thermogenin — Mechanism · splits 30 ⟂ 21
Thermogenin — Evolution · splits 35 ⟂ 16
Thermogenin — History · splits 45 ⟂ 6
Thermogenin — Overview · splits 46 ⟂ 5

Map overview Semantic statistics

Thermogenin

Nodes51
Edges50
Triples105
Avg. degree1.96
Density0.039216
Components1

Source & methodology

TTTA analyzes the structure around Thermogenin to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Mechanism & Evolution, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Thermogenin · EN edition · Analysis: TopicsToTalkAbout

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