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Surrogate endpoint

In clinical trials, a surrogate endpoint (also called a surrogate measure or surrogate marker) is a measure of effect of a specific treatment that may correlate with a real clinical endpoint but does not necessarily have a guaranteed relationship. The National Institutes of Health (USA) defines surrogate endpoint as "a biomarker intended to substitute…

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Overview

Examples

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Map overview Semantic statistics

Surrogate endpoint

Nodes37
Edges36
Triples39
Avg. degree1.95
Density0.054054
Components1

How this topic connects Entity context

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Surrogate endpoint

Top relations

related to Cancer · 10
Surrogate endpoint → Avastin, Bevacizumab, Drug Administration, Food, In, More, Oncology, Overall Treatment Utility, Progression Free Survival, There
related to Cardiovascular disease · 9
Surrogate endpoint → AstraZeneca, Crestor, Death, In, Proof, The, While, Zocor, Zocor's
related to Infectious disease · 6
Surrogate endpoint → CD4, Direct Acting Antivirals, In, In HIV/AIDS, Sustained Virological Response, The
related to Criticism · 4
Surrogate endpoint → Aduhelm, FDA, In, There
related to Reporting Guidelines · 4
Surrogate endpoint → CONSORT, Reporting, SPIRIT, This
see also · 1
Surrogate endpoint → FDA Accelerated Approval Program

Important terminology Word statistics

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Important terminology

surrogate endpoint clinical used endpoints trials markers correlate disease cholesterol drug approval show trial meaningful fda called marker treatment may

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Overall Treatment Utility.Infectious diseaseIn HIV/AIDS medicineinstance ofMore patient focused surrogate endpoints may offer a more meaningful alternative0.80text
CD4 countsinstance ofMore patient focused surrogate endpoints may offer a more meaningful alternative0.80text
viral loads are used as surrogate markers for drug approval for clinical trials.In hepatitis C medicineinstance ofMore patient focused surrogate endpoints may offer a more meaningful alternative0.80text
the surrogate endpointinstance ofMore patient focused surrogate endpoints may offer a more meaningful alternative0.80text
Overall Treatment Utilityinstance ofMore patient focused surrogate endpoints may offer a more meaningful alternative0.80text
Surrogate endpointrelated to CancerProgression Free Survival0.60section
Surrogate endpointrelated to CancerOncology0.60section
Surrogate endpointrelated to CancerThere0.60section
Surrogate endpointrelated to CancerIn0.60section
Surrogate endpointrelated to CancerBevacizumab0.60section
Surrogate endpointrelated to CancerAvastin0.60section
Surrogate endpointrelated to CancerFood0.60section

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    Min side: 3
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