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Substitution model

In biology, a substitution model, also called models of sequence evolution, are Markov models that describe changes over evolutionary time. These models describe evolutionary changes in macromolecules, such as DNA sequences or protein sequences, that can be represented as a sequence of symbols (e.g., A, C, G, and T in the case of DNA or the 20 "standard"…

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Substitution model

Nodes103
Edges102
Triples53
Avg. degree1.98
Density0.019417
Components1

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Substitution model

Top relations

related to Sequence data · 12
Substitution model → DNA, DNA/RNA, GGGG, However, If, In, Jukes-Cantor, Models, Most, RNA, The, This
related to Morphological data · 10
Substitution model → However, In, Karl Popper, Many, MP, The, There, This, Typically, Using
related to Stationarity, reversibility, and homogeneity · 8
Substitution model → Formally, Homogeneity, In, Reversibility, Stationarity, Substitution, These, This
related to Phylogenetic tree topologies and other parameters · 5
Substitution model → For, However, Other, Phylogenetic, The Ka/Ks
related to Time-reversible and stationary models · 5
Substitution model → However, Instead, Many, This, When

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Important terminology

model models parameters substitution displaystyle data matrix sequence using amino used evolution also time tree rate number dna equilibrium frequencies

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
neighbor joininginstance ofevolutionary distances are used as input for distance methods0.80text
the presence or absence of a morphological innovation.Amino acid substitution modelsFor many analysesinstance ofbut can matter a lot for other types of binary data0.80text
particularly for longer evolutionary distancesinstance ofbut can matter a lot for other types of binary data0.80text
the evolution is modeled on the amino acid levelinstance ofbut can matter a lot for other types of binary data0.80text
PAM250instance ofknown under names0.80text
Moore's lawinstance ofreflecting factors0.80text
nuclear proteinsinstance ofThese substitution models are derived from protein sequences of different taxonomic groups and protein families0.80text
chloroplast proteinsinstance ofThese substitution models are derived from protein sequences of different taxonomic groups and protein families0.80text
mitochondrial proteinsinstance ofThese substitution models are derived from protein sequences of different taxonomic groups and protein families0.80text
and viral proteinsinstance ofThese substitution models are derived from protein sequences of different taxonomic groups and protein families0.80text
among others.A singular empirical model assume a constant set of amino acid frequencies over the entire evolutionary treeinstance ofThese substitution models are derived from protein sequences of different taxonomic groups and protein families0.80text
which is often not the case over wide-spanning treesinstance ofThese substitution models are derived from protein sequences of different taxonomic groups and protein families0.80text

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