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In biology, a substitution model, also called models of sequence evolution, are Markov models that describe changes over evolutionary time. These models describe evolutionary changes in macromolecules, such as DNA sequences or protein sequences, that can be represented as a sequence of symbols (e.g., A, C, G, and T in the case of DNA or the 20 "standard"…
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model models parameters substitution displaystyle data matrix sequence using amino used evolution also time tree rate number dna equilibrium frequencies
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| neighbor joining | instance of | evolutionary distances are used as input for distance methods | 0.80 | text |
| the presence or absence of a morphological innovation.Amino acid substitution modelsFor many analyses | instance of | but can matter a lot for other types of binary data | 0.80 | text |
| particularly for longer evolutionary distances | instance of | but can matter a lot for other types of binary data | 0.80 | text |
| the evolution is modeled on the amino acid level | instance of | but can matter a lot for other types of binary data | 0.80 | text |
| PAM250 | instance of | known under names | 0.80 | text |
| Moore's law | instance of | reflecting factors | 0.80 | text |
| nuclear proteins | instance of | These substitution models are derived from protein sequences of different taxonomic groups and protein families | 0.80 | text |
| chloroplast proteins | instance of | These substitution models are derived from protein sequences of different taxonomic groups and protein families | 0.80 | text |
| mitochondrial proteins | instance of | These substitution models are derived from protein sequences of different taxonomic groups and protein families | 0.80 | text |
| and viral proteins | instance of | These substitution models are derived from protein sequences of different taxonomic groups and protein families | 0.80 | text |
| among others.A singular empirical model assume a constant set of amino acid frequencies over the entire evolutionary tree | instance of | These substitution models are derived from protein sequences of different taxonomic groups and protein families | 0.80 | text |
| which is often not the case over wide-spanning trees | instance of | These substitution models are derived from protein sequences of different taxonomic groups and protein families | 0.80 | text |
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