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SRGAP2: Evolution & Overview
SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2), also known as formin-binding protein 2 (FNBP2), is a mammalian protein that in humans is encoded by the SRGAP2 gene. It is involved in neuronal migration and differentiation and plays a critical role in synaptic development, brain mass and number of cortical neurons. Downregulation of srGAP2 inhibits…
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SRGAP2 topic overview
The analysis highlights Evolution and Overview as prominent areas in the source structure around SRGAP2.
Related topics
22
Source areas
2
Connected nodes
24
Extracted relationships
110
Concept neighborhoods
11
Bridge connections
24
What this topic covers Research coverage
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Evolution · 12 topics
Overview · 10 topics
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
Key facts & relationships
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4RTT, 4RUG, 2DL8
Band
1q32.1 · 1|1 E4
Bgee
cerebellar hemisphere · right hemisphere of cerebellum · sural nerve · paraflocculus of cerebellum · ventricular zone
BioGPS
n/a
Chr.
Chromosome 1 (human) · Chromosome 1 (mouse)
Explore all related topics Closing gaps
A structured outline of related entities, concepts and subtopics. Open any item to build a new map centered on it.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
How SRGAP2 connects Entity context
Entity context groups extracted connections by relationship type. Counts show recurrence in the analyzed source; the examples are research signals, not claims about importance.
The extracted context around SRGAP2 shows recurring relationship patterns in the source. For example, SRGAP2 → actin filament severing, cell junction, cell population proliferation, cell projection, cytoplasm, cytoplasmic vesicle, cytosol, dendritic spine, dendritic spine development, dendritic spine head, extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration, filopodium assembly, GTPase activator activity, identical protein binding, lamellipodium, lamellipodium assembly involved in ameboidal cell migration, membrane, negative regulation of cell death, negative regulation of cell migration, negative regulation of neuron migration Another extracted example is SRGAP2 → C1 segment, cerebellar cortex, cerebellar hemisphere, cerebellar vermis, dentate gyrus of hippocampal formation granule cell, ganglionic eminence, lip, lobe of cerebellum, lumbar subsegment of spinal cord, monocyte, paraflocculus of cerebellum, right hemisphere of cerebellum, Rostral migratory stream, skin of abdomen, skin of leg, stroma of bone marrow, superior frontal gyrus, sural nerve, tail of embryo, ventricular zone. Use these groups to spot repeated connection types before inspecting the individual relationships.
SRGAP2
Top relations
Gene ontology· 35
SRGAP2 → actin filament severing, cell junction, cell population proliferation, cell projection, cytoplasm, cytoplasmic vesicle, cytosol, dendritic spine, dendritic spine development, dendritic spine head, extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration, filopodium assembly, GTPase activator activity, identical protein binding, lamellipodium, lamellipodium assembly involved in ameboidal cell migration, membrane, negative regulation of cell death, negative regulation of cell migration, negative regulation of neuron migration
Bgee· 20
SRGAP2 → C1 segment, cerebellar cortex, cerebellar hemisphere, cerebellar vermis, dentate gyrus of hippocampal formation granule cell, ganglionic eminence, lip, lobe of cerebellum, lumbar subsegment of spinal cord, monocyte, paraflocculus of cerebellum, right hemisphere of cerebellum, Rostral migratory stream, skin of abdomen, skin of leg, stroma of bone marrow, superior frontal gyrus, sural nerve, tail of embryo, ventricular zone
RNA expression pattern· 20
SRGAP2 → C1 segment, cerebellar cortex, cerebellar hemisphere, cerebellar vermis, dentate gyrus of hippocampal formation granule cell, ganglionic eminence, lip, lobe of cerebellum, lumbar subsegment of spinal cord, monocyte, paraflocculus of cerebellum, right hemisphere of cerebellum, Rostral migratory stream, skin of abdomen, skin of leg, stroma of bone marrow, superior frontal gyrus, sural nerve, tail of embryo, ventricular zone
related to Evolution· 12
SRGAP2 → All, Denisovans, F-box, Neanderthals, Not, RhoGAP, SH3, SRGAP2A, SRGAP2B, SRGAP2C, SRGAP2D, They
Relationships are represented as Subject → Predicate → Object triples. Confidence describes extraction strength, not the real-world importance of a relationship; lower-confidence rows may be contextual rather than explicit.
TTTA extracted 110 structured relationships around SRGAP2. Examples in this analysis include SRGAP2 → Aliases → SRGAP2, ARHGAP34, FNBP2, SRGAP2A, SRGAP3, SLIT-ROBO Rho GTPase activating protein 2 and SRGAP2 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4RTT, 4RUG, 2DL8. The table shows each extracted connection, where it came from and its confidence.
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4RTT, 4RUG, 2DL8
1.00
infobox
SRGAP2
Band
1q32.1
1.00
infobox
SRGAP2
Band
1|1 E4
1.00
infobox
SRGAP2
Bgee
cerebellar hemisphere
1.00
infobox
SRGAP2
Bgee
right hemisphere of cerebellum
1.00
infobox
SRGAP2
Bgee
sural nerve
1.00
infobox
SRGAP2
Bgee
paraflocculus of cerebellum
1.00
infobox
SRGAP2
Bgee
ventricular zone
1.00
infobox
SRGAP2
Bgee
skin of leg
1.00
infobox
SRGAP2
Bgee
ganglionic eminence
1.00
infobox
SRGAP2
Bgee
skin of abdomen
1.00
infobox
SRGAP2
Bgee
C1 segment
1.00
infobox
SRGAP2
Bgee
monocyte
1.00
infobox
SRGAP2
Bgee
lumbar subsegment of spinal cord
1.00
infobox
SRGAP2
Bgee
cerebellar cortex
1.00
infobox
SRGAP2
Bgee
tail of embryo
1.00
infobox
SRGAP2
Bgee
lobe of cerebellum
1.00
infobox
SRGAP2
Bgee
cerebellar vermis
1.00
infobox
SRGAP2
Bgee
stroma of bone marrow
1.00
infobox
SRGAP2
Bgee
Rostral migratory stream
1.00
infobox
SRGAP2
Bgee
superior frontal gyrus
1.00
infobox
SRGAP2
Bgee
dentate gyrus of hippocampal formation granule cell
1.00
infobox
SRGAP2
Bgee
lip
1.00
infobox
SRGAP2
BioGPS
n/a
1.00
infobox
SRGAP2
Chr.
Chromosome 1 (human)
1.00
infobox
SRGAP2
Chr.
Chromosome 1 (mouse)
1.00
infobox
SRGAP2
Databases
NCBI: entry; OMA: entry
1.00
infobox
SRGAP2
End
206,464,436 bp
1.00
infobox
SRGAP2
End
131,455,090 bp
1.00
infobox
No triples extracted yet.
Related concept clusters Concept neighborhoods
Concept neighborhoods group terms that sit near one another in the extracted graph. They are useful for discovering adjacent language and context, but proximity does not by itself imply a factual relationship.
The concept neighborhoods around SRGAP2 bring nearby vocabulary together. In this analysis, examples include Srgap2b, Srgap2d and Srgap2c. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
protein
Gene
Fnbp2
Gtpase
Known
Rho
Search
Slit-robo
Location
Srgap2
Chromosome
Bp
Chr
gene
Location
Protein
Chromosome
Bp
Chr
End
Gtpase
Human
Known
Mouse
Rho
Search
synaptic development
Involved
Migration
Neurons
Inhibits
Maturation
Neuronal
Cell
Density
Development
End
Gtpase
Known
neuronal migration
Neurons
Synaptic
Density
Maturation
Spine
Cell
End
Gtpase
Inhibits
Mouse
Neuronal
Search
human genome
Location
Band
End
Mouse
Search
Protein
Srgap2
Known
Rho
Slit-robo
Spine
Involved
f-bar domain
Domain
F-bar
Shortened
Srgap2c
Humans
Srgap2
srgap2d
Srgap2b
Srgap2c
Human
Humans
Srgap2
SRGAP2
Srgap2b
Srgap2d
Srgap2c
Connections between topic areas Semantic bridges
Semantic bridges connect parts of the graph that would otherwise be more separate. A bridge is a structural signal in this analysis, not a claim that the two topic areas are equivalent.
For SRGAP2, one of the stronger structural bridges in this analysis connects SRGAP2 with Evolution. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
Number of nodes, edges, triples, density and central hubs. Use it to gauge the size and connectivity of the map.
SRGAP2
Nodes25
Edges24
Triples110
Avg. degree1.92
Density0.08
Components1
Source & methodology
TTTA analyzes the structure around SRGAP2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Evolution & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
