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SRGAP2

SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2), also known as formin-binding protein 2 (FNBP2), is a mammalian protein that in humans is encoded by the SRGAP2 gene. It is involved in neuronal migration and differentiation and plays a critical role in synaptic development, brain mass and number of cortical neurons. Downregulation of srGAP2 inhibits…

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Aliases
SRGAP2, ARHGAP34, FNBP2, SRGAP2A, SRGAP3, SLIT-ROBO Rho GTPase activating protein 2
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4RTT, 4RUG, 2DL8
Band
1q32.1 · 1|1 E4
Bgee
cerebellar hemisphere · right hemisphere of cerebellum · sural nerve · paraflocculus of cerebellum · ventricular zone
BioGPS
n/a
Chr.
Chromosome 1 (human) · Chromosome 1 (mouse)

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SRGAP2

Nodes25
Edges24
Triples110
Avg. degree1.92
Density0.08
Components1

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SRGAP2

Top relations

Gene ontology · 35
SRGAP2 → actin filament severing, cell junction, cell population proliferation, cell projection, cytoplasm, cytoplasmic vesicle, cytosol, dendritic spine, dendritic spine development, dendritic spine head, extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration, filopodium assembly, GTPase activator activity, identical protein binding, lamellipodium, lamellipodium assembly involved in ameboidal cell migration, membrane, negative regulation of cell death, negative regulation of cell migration, negative regulation of neuron migration
Bgee · 20
SRGAP2 → C1 segment, cerebellar cortex, cerebellar hemisphere, cerebellar vermis, dentate gyrus of hippocampal formation granule cell, ganglionic eminence, lip, lobe of cerebellum, lumbar subsegment of spinal cord, monocyte, paraflocculus of cerebellum, right hemisphere of cerebellum, Rostral migratory stream, skin of abdomen, skin of leg, stroma of bone marrow, superior frontal gyrus, sural nerve, tail of embryo, ventricular zone
RNA expression pattern · 20
SRGAP2 → C1 segment, cerebellar cortex, cerebellar hemisphere, cerebellar vermis, dentate gyrus of hippocampal formation granule cell, ganglionic eminence, lip, lobe of cerebellum, lumbar subsegment of spinal cord, monocyte, paraflocculus of cerebellum, right hemisphere of cerebellum, Rostral migratory stream, skin of abdomen, skin of leg, stroma of bone marrow, superior frontal gyrus, sural nerve, tail of embryo, ventricular zone
related to Evolution · 12
SRGAP2 → All, Denisovans, F-box, Neanderthals, Not, RhoGAP, SH3, SRGAP2A, SRGAP2B, SRGAP2C, SRGAP2D, They
Band · 2
SRGAP2 → 1q32.1, 1|1 E4
Chr. · 2
SRGAP2 → Chromosome 1 (human), Chromosome 1 (mouse)
End · 2
SRGAP2 → 131,455,090 bp, 206,464,436 bp
Aliases · 1
SRGAP2 → SRGAP2, ARHGAP34, FNBP2, SRGAP2A, SRGAP3, SLIT-ROBO Rho GTPase activating protein 2
Available structures · 1
SRGAP2 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4RTT, 4RUG, 2DL8
BioGPS · 1
SRGAP2 → n/a

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Important terminology

bp human chr band humans gene srgap2c chromosome involved development protein also neurons domain migration density location neuronal f-bar srgap2b

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
SRGAP2AliasesSRGAP2, ARHGAP34, FNBP2, SRGAP2A, SRGAP3, SLIT-ROBO Rho GTPase activating protein 21.00infobox
SRGAP2Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4RTT, 4RUG, 2DL81.00infobox
SRGAP2Band1q32.11.00infobox
SRGAP2Band1|1 E41.00infobox
SRGAP2Bgeecerebellar hemisphere1.00infobox
SRGAP2Bgeeright hemisphere of cerebellum1.00infobox
SRGAP2Bgeesural nerve1.00infobox
SRGAP2Bgeeparaflocculus of cerebellum1.00infobox
SRGAP2Bgeeventricular zone1.00infobox
SRGAP2Bgeeskin of leg1.00infobox
SRGAP2Bgeeganglionic eminence1.00infobox
SRGAP2Bgeeskin of abdomen1.00infobox
SRGAP2BgeeC1 segment1.00infobox
SRGAP2Bgeemonocyte1.00infobox
SRGAP2Bgeelumbar subsegment of spinal cord1.00infobox
SRGAP2Bgeecerebellar cortex1.00infobox
SRGAP2Bgeetail of embryo1.00infobox
SRGAP2Bgeelobe of cerebellum1.00infobox
SRGAP2Bgeecerebellar vermis1.00infobox
SRGAP2Bgeestroma of bone marrow1.00infobox
SRGAP2BgeeRostral migratory stream1.00infobox
SRGAP2Bgeesuperior frontal gyrus1.00infobox
SRGAP2Bgeedentate gyrus of hippocampal formation granule cell1.00infobox
SRGAP2Bgeelip1.00infobox
SRGAP2BioGPSn/a1.00infobox
SRGAP2Chr.Chromosome 1 (human)1.00infobox
SRGAP2Chr.Chromosome 1 (mouse)1.00infobox
SRGAP2DatabasesNCBI: entry; OMA: entry1.00infobox
SRGAP2End206,464,436 bp1.00infobox
SRGAP2End131,455,090 bp1.00infobox

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