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Split gene theory

The split gene theory offers an explanation for the origin of eukaryotic introns. It suggests that random primordial DNA sequences would only permit short (< 600bp) open reading frames (ORFs) due to frequent stop codons. The short ORFs could have contained the short protein-coding exons observed in eukaryotic genes, whereas the intervening sequences with…

History, Background & Testing the hypothesis

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Overview

Background

History

Hypothesis

Testing the hypothesis

Short exons/long introns

Eukaryotes

Corroborating evidence

Selected publications

  • Doi Doi (identifier)
  • PMC PMC (identifier)
  • PMID PMID (identifier)
  • Bibcode Bibcode (identifier)
  • ISBN ISBN (identifier)

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Map overview Semantic statistics

Split gene theory

Nodes52
Edges51
Triples60
Avg. degree1.96
Density0.038462
Components1

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Split gene theory

Top relations

related to Short exons/long introns · 14
Split gene theory → CNTNAP2, DLG2, DNA, Frequent, Furthermore, If, In, ORFs, PTPRD, RBFOX1, Research, Senapathy, The, These
related to Origin of splice junctions · 12
Split gene theory → AG, As, GT, If, In, It, ORF, ORFs, This, Thus, Under, When Senapathy
related to Bacterial genes · 10
Split gene theory → According, Based, DNA, Genes, However, It, ORFs, Senapathy, These, Thus
related to Spliceosomal machinery and eukaryotic nucleus · 9
Split gene theory → Blake, DNA, If, It, RNA, Senapathy, The, Thus, Work
related to Corroborating evidence · 8
Split gene theory → Actually, DNA, ORF, RNA, The, These, This, With
related to Stop codons are key parts of every genetic element in the eukaryotic gene · 4
Split gene theory → DNA, Senapathy, The, This

Important terminology Word statistics

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Important terminology

introns genes eukaryotic sequences exons stop split sequence codons theory random gene senapathy splice dna rna organisms short origin splicing

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Amoeboflagellatainstance ofconsidered to be primitive eukaryotic organisms0.80text
Diplomonadidainstance ofconsidered to be primitive eukaryotic organisms0.80text
and Parabasaliainstance ofconsidered to be primitive eukaryotic organisms0.80text
Split gene theoryrelated to Bacterial genesGenes0.60section
Split gene theoryrelated to Bacterial genesHowever0.60section
Split gene theoryrelated to Bacterial genesIt0.60section
Split gene theoryrelated to Bacterial genesORFs0.60section
Split gene theoryrelated to Bacterial genesAccording0.60section
Split gene theoryrelated to Bacterial genesDNA0.60section
Split gene theoryrelated to Bacterial genesThese0.60section
Split gene theoryrelated to Bacterial genesSenapathy0.60section
Split gene theoryrelated to Bacterial genesThus0.60section

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