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Sortase

Sortase refers to a group of prokaryotic peptidases that modify surface proteins by recognizing and cleaving a carboxyl-terminal sorting signal. For most substrates of sortase enzymes, the recognition signal consists of the motif LPXTG (Leu-Pro-any-Thr-Gly), then a highly hydrophobic transmembrane sequence, followed by a cluster of basic residues such as…

Applications, Pharmaceutic Applications & Structure

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AlphaFold
IPR005754 · PF04203
Available protein structures:
IPR005754 · PF04203
CDD
cd00004
InterPro
IPR005754
OPM protein
1rz2
OPM superfamily
294

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Biological role

Pharmaceutic Applications

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Map overview Semantic statistics

Sortase

Nodes36
Edges35
Triples55
Avg. degree1.94
Density0.055556
Components1

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Sortase

Top relations

related to Structural Variants · 12
Sortase → Another, Different, LAXTG, LPXSG, LPXTG, NPQTN, SrtA, SrtB, The, These, This, To
related to Use in structural biology · 8
Sortase → C-terminus, LPXTG, N-terminus, NMR, The, This, Upon, X-ray
related to Biological role · 7
Sortase → In, It, Sec, Substrate, Surface, The, These
related to Structure · 5
Sortase → Another, C60, C60B, MEROPS, This
related to Antibody Drug Conjugates · 4
Sortase → ADCs, Antibody, Due, Using
related to Reaction · 4
Sortase → Gly, LPXTG, The Staphylococcus, Thr
AlphaFold · 2
Sortase → IPR005754, PF04203
Available protein structures: · 2
Sortase → IPR005754, PF04203
CDD · 1
Sortase → cd00004
InterPro · 1
Sortase → IPR005754

Important terminology Word statistics

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Important terminology

proteins protein surface motif sortases enzyme cell variants aureus binding bacteria wall srta adcs lpxtg site signal reaction group used

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
SortaseAlphaFoldIPR0057541.00infobox
SortaseAlphaFoldPF042031.00infobox
SortaseAvailable protein structures:IPR0057541.00infobox
SortaseAvailable protein structures:PF042031.00infobox
SortaseCDDcd000041.00infobox
SortaseInterProIPR0057541.00infobox
SortaseOPM protein1rz21.00infobox
SortaseOPM superfamily2941.00infobox
SortasePDBIPR005754 PF04203 (ECOD; PDBsum)1.00infobox
SortasePfamPF042031.00infobox
SortaseSCOP21ija / SCOPe / SUPFAM1.00infobox
SortaseSymbolSortase1.00infobox
Sortaseis atranspeptidase that attaches surface proteins to the cell wall0.90text

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