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Semaphorin-4D (SEMA4D) also known as Cluster of Differentiation 100 (CD100), is a protein of the semaphorin family that in humans is encoded by the SEMA4D gene.
The analysis highlights Function and Overview as prominent areas in the source structure around SEMA4D.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
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The extracted context around SEMA4D shows recurring relationship patterns in the source. For example, SEMA4D → cell adhesion, cell differentiation, chemorepellent activity, extracellular space, identical protein binding, immune response, integral component of membrane, integral component of plasma membrane, leukocyte aggregation, membrane, multicellular organism development, negative chemotaxis, negative regulation of alkaline phosphatase activity, negative regulation of apoptotic process, negative regulation of axon extension involved in axon guidance, negative regulation of cell adhesion, negative regulation of osteoblast differentiation, negative regulation of peptidyl-tyrosine phosphorylation, negative regulation of transcription by RNA polymerase II, nervous system development Another extracted example is SEMA4D → blood, C1 segment, corpus callosum, cumulus cell, dentate gyrus of hippocampal formation granule cell, granulocyte, inferior ganglion of vagus nerve, internal globus pallidus, lumbar subsegment of spinal cord, lymph node, mesenteric lymph nodes, monocyte, muscle of thigh, spleen, substantia nigra, thymus, tibiofemoral joint. Use these groups to spot repeated connection types before inspecting the individual relationships.
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bp human chr band gene semaphorin chromosome protein system differentiation cd100 location also mouse nervous axon function external cluster search
TTTA extracted 99 structured relationships around SEMA4D. Examples in this analysis include SEMA4D → Aliases → SEMA4D, C9orf164, CD100, M-sema-G, SEMAJ, coll-4, semaphorin 4D, COLL4, A8, GR3, BB18 and SEMA4D → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1OLZ, 3OL2. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| SEMA4D | Aliases | SEMA4D, C9orf164, CD100, M-sema-G, SEMAJ, coll-4, semaphorin 4D, COLL4, A8, GR3, BB18 | 1.00 | infobox |
| SEMA4D | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1OLZ, 3OL2 | 1.00 | infobox |
| SEMA4D | Band | 9q22.2 | 1.00 | infobox |
| SEMA4D | Band | 13|13 A5 | 1.00 | infobox |
| SEMA4D | Bgee | C1 segment | 1.00 | infobox |
| SEMA4D | Bgee | granulocyte | 1.00 | infobox |
| SEMA4D | Bgee | corpus callosum | 1.00 | infobox |
| SEMA4D | Bgee | blood | 1.00 | infobox |
| SEMA4D | Bgee | monocyte | 1.00 | infobox |
| SEMA4D | Bgee | inferior ganglion of vagus nerve | 1.00 | infobox |
| SEMA4D | Bgee | lymph node | 1.00 | infobox |
| SEMA4D | Bgee | muscle of thigh | 1.00 | infobox |
| SEMA4D | Bgee | internal globus pallidus | 1.00 | infobox |
| SEMA4D | Bgee | substantia nigra | 1.00 | infobox |
| SEMA4D | Bgee | mesenteric lymph nodes | 1.00 | infobox |
| SEMA4D | Bgee | thymus | 1.00 | infobox |
| SEMA4D | Bgee | lumbar subsegment of spinal cord | 1.00 | infobox |
| SEMA4D | Bgee | cumulus cell | 1.00 | infobox |
| SEMA4D | Bgee | tibiofemoral joint | 1.00 | infobox |
| SEMA4D | Bgee | dentate gyrus of hippocampal formation granule cell | 1.00 | infobox |
| SEMA4D | Bgee | spleen | 1.00 | infobox |
| SEMA4D | BioGPS | More reference expression data | 1.00 | infobox |
| SEMA4D | Chr. | Chromosome 9 (human) | 1.00 | infobox |
| SEMA4D | Chr. | Chromosome 13 (mouse) | 1.00 | infobox |
| SEMA4D | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| SEMA4D | End | 89,498,130 bp | 1.00 | infobox |
| SEMA4D | End | 51,793,747 bp | 1.00 | infobox |
| SEMA4D | Ensembl | ENSG00000187764 | 1.00 | infobox |
| SEMA4D | Entrez | 10507 | 1.00 | infobox |
| SEMA4D | External IDs | OMIM: 601866; MGI: 109244; GeneCards: SEMA4D | 1.00 | infobox |
The concept neighborhoods around SEMA4D bring nearby vocabulary together. In this analysis, examples include Differentiation, Semaphorin and Gene. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For SEMA4D, one of the stronger structural bridges in this analysis connects SEMA4D with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around SEMA4D to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — SEMA4D · EN edition · Analysis: TopicsToTalkAbout
