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SEMA4A: Clinical significance, Function & Overview

Semaphorin-4A is a protein that in humans is encoded by the SEMA4A gene.

Language: English [EN]
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SEMA4A topic overview

The analysis highlights Clinical significance, Function and Overview as prominent areas in the source structure around SEMA4A.

Related topics
5
Source areas
3
Connected nodes
8
Extracted relationships
92
Concept neighborhoods
7
Bridge connections
8

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Clinical significance · 2 topics
Overview · 2 topics
Function · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
SEMA4A, CORD10, RP35, SEMAB, SEMB, semaphorin 4A
Band
1q22 · 3|3 F1
Bgee
monocyte · granulocyte · bone marrow cell · blood · amygdala
BioGPS
More reference expression data
Chr.
Chromosome 1 (human) · Chromosome 3 (mouse)
Databases
NCBI: entry; OMA: entry

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How SEMA4A connects Entity context

The extracted context around SEMA4A shows recurring relationship patterns in the source. For example, SEMA4A → adaptive immune response, angiogenesis, axonogenesis, cell differentiation, chemorepellent activity, cytosol, extracellular space, immune system process, integral component of membrane, integral component of plasma membrane, intracellular membrane-bounded organelle, membrane, multicellular organism development, negative chemotaxis, negative regulation of angiogenesis, negative regulation of axon extension involved in axon guidance, nervous system development, neural crest cell migration, neuropilin binding, nucleus Another extracted example is SEMA4A → amygdala, arcuate nucleus, blood, bone marrow cell, cingulate gyrus, duodenum, granulocyte, ileum, jejunum, left lobe of thyroid gland, monocyte, nucleus accumbens, Paneth cell, paraventricular nucleus of hypothalamus, prostate, retinal pigment epithelium, skin of abdomen, ventromedial nucleus. Use these groups to spot repeated connection types before inspecting the individual relationships.

SEMA4A

Top relations

Gene ontology · 31
SEMA4A → adaptive immune response, angiogenesis, axonogenesis, cell differentiation, chemorepellent activity, cytosol, extracellular space, immune system process, integral component of membrane, integral component of plasma membrane, intracellular membrane-bounded organelle, membrane, multicellular organism development, negative chemotaxis, negative regulation of angiogenesis, negative regulation of axon extension involved in axon guidance, nervous system development, neural crest cell migration, neuropilin binding, nucleus
Bgee · 18
SEMA4A → amygdala, arcuate nucleus, blood, bone marrow cell, cingulate gyrus, duodenum, granulocyte, ileum, jejunum, left lobe of thyroid gland, monocyte, nucleus accumbens, Paneth cell, paraventricular nucleus of hypothalamus, prostate, retinal pigment epithelium, skin of abdomen, ventromedial nucleus
RNA expression pattern · 18
SEMA4A → amygdala, arcuate nucleus, blood, bone marrow cell, cingulate gyrus, duodenum, granulocyte, ileum, jejunum, left lobe of thyroid gland, monocyte, nucleus accumbens, Paneth cell, paraventricular nucleus of hypothalamus, prostate, retinal pigment epithelium, skin of abdomen, ventromedial nucleus
related to Clinical significance · 3
SEMA4A → Multiple, Recently, V78M
Band · 2
SEMA4A → 1q22, 3|3 F1
Chr. · 2
SEMA4A → Chromosome 1 (human), Chromosome 3 (mouse)
End · 2
SEMA4A → 156,177,752 bp, 88,368,489 bp
related to Function · 2
SEMA4A → OMIM, Semaphorins
Aliases · 1
SEMA4A → SEMA4A, CORD10, RP35, SEMAB, SEMB, semaphorin 4A
BioGPS · 1
SEMA4A → More reference expression data

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

bp chr human band gene chromosome location semaphorin protein mouse function 177 752 end 156 368 489 omim immune development

SEMA4A relationships Subject–Predicate–Object triples

TTTA extracted 92 structured relationships around SEMA4A. Examples in this analysis include SEMA4A → Aliases → SEMA4A, CORD10, RP35, SEMAB, SEMB, semaphorin 4A and SEMA4A → Band → 1q22. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
SEMA4AAliasesSEMA4A, CORD10, RP35, SEMAB, SEMB, semaphorin 4A1.00infobox
SEMA4ABand1q221.00infobox
SEMA4ABand3|3 F11.00infobox
SEMA4ABgeemonocyte1.00infobox
SEMA4ABgeegranulocyte1.00infobox
SEMA4ABgeebone marrow cell1.00infobox
SEMA4ABgeeblood1.00infobox
SEMA4ABgeeamygdala1.00infobox
SEMA4ABgeenucleus accumbens1.00infobox
SEMA4ABgeeskin of abdomen1.00infobox
SEMA4ABgeeleft lobe of thyroid gland1.00infobox
SEMA4ABgeeretinal pigment epithelium1.00infobox
SEMA4ABgeecingulate gyrus1.00infobox
SEMA4ABgeePaneth cell1.00infobox
SEMA4ABgeeventromedial nucleus1.00infobox
SEMA4ABgeejejunum1.00infobox
SEMA4ABgeeparaventricular nucleus of hypothalamus1.00infobox
SEMA4ABgeearcuate nucleus1.00infobox
SEMA4ABgeeprostate1.00infobox
SEMA4ABgeeileum1.00infobox
SEMA4ABgeeduodenum1.00infobox
SEMA4ABioGPSMore reference expression data1.00infobox
SEMA4AChr.Chromosome 1 (human)1.00infobox
SEMA4AChr.Chromosome 3 (mouse)1.00infobox
SEMA4ADatabasesNCBI: entry; OMA: entry1.00infobox
SEMA4AEnd156,177,752 bp1.00infobox
SEMA4AEnd88,368,489 bp1.00infobox
SEMA4AEnsemblENSG000001961891.00infobox
SEMA4AEntrez642181.00infobox
SEMA4AExternal IDsOMIM: 607292; MGI: 107560; GeneCards: SEMA4A1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around SEMA4A bring nearby vocabulary together. In this analysis, examples include Gene, Development and Function. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • gene
    • Location
    • Chromosome
    • Human
    • Sema4a
    • Bp
    • Chr
    • End
    • Function
    • Mouse
    • Protein
    • Semaphorin
    • Band
  • SEMA4A
    • Gene
    • Development
    • Function
    • Guidance
    • Immune
    • Involved
    • Migration
    • Omim
    • Semaphorin
    • Location
    • Chromosome
    • Human
  • sema4a
    • Gene
    • Development
    • Function
    • Guidance
    • Immune
    • Involved
    • Migration
    • Omim
    • Semaphorin
    • Location
    • Chromosome
    • Human
  • function
    • Semaphorin
    • Location
    • Chromosome
    • Gene
    • Human
    • Reading
    • References
    • Sema4a
    • Significance
    • Bp
    • Chr
    • Development
  • protein
    • Encoded
    • Gene
    • Humans
    • Sema4a
    • Semaphorin-4a
    • Development
    • End
    • Function
    • Guidance
    • Immune
    • Involved
    • Migration
  • clinical significance
    • Clinical
    • Reading
    • References
    • Significance
    • Function
    • Omim
    • Semaphorin
    • Location
    • Chromosome
    • Gene
    • Human
    • Sema4a
  • semaphorin
    • Location
    • Human
    • Significance
    • Development
    • End
    • Guidance
    • Immune
    • Involved
    • Migration
    • Mouse
    • Omim
    • Band

Connections between topic areas Semantic bridges

For SEMA4A, one of the stronger structural bridges in this analysis connects SEMA4A with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
SEMA4AOverview · splits 6 ⟂ 3
SEMA4AClinical significance · splits 6 ⟂ 3

Map overview Semantic statistics

SEMA4A

Nodes9
Edges8
Triples92
Avg. degree1.78
Density0.222222
Components1

Source & methodology

TTTA analyzes the structure around SEMA4A to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Clinical significance, Function & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — SEMA4A · EN edition · Analysis: TopicsToTalkAbout

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