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Eosinophil cationic protein

Eosinophil cationic protein (ECP) also known as ribonuclease 3 is a basic protein located in the eosinophil primary matrix. In humans, the eosinophil cationic protein is encoded by the RNASE3 gene.

Measurement, Clinical significance & Function

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Clinical significance

12 related topics

Function

6 related topics

Ribonuclease activity and cytotoxicity

4 related topics

ECP-induced apoptosis

2 related topics

Key facts & relationships

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Aliases
RNASE3, ECP, RNS3, RAF1, ribonuclease A family member 3
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4A2O, 4X08, 1DYT, 4OXB, 2LVZ, 2KB5, 4OXF, 1QMT, 4OWZ, 1H1H, 4A2Y
Band
14q11.2
Bgee
trabecular bone · bone marrow · bone marrow cell · testicle · mononuclear cell
BioGPS
n/a
Chr.
Chromosome 14 (human)

Topics to explore

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Overview

Function

Ribonuclease activity and cytotoxicity

ECP-induced apoptosis

Clinical significance

Advanced semantic analysis

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Map overview Semantic statistics

Eosinophil cationic protein

Nodes34
Edges33
Triples64
Avg. degree1.94
Density0.058824
Components1

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Eosinophil cationic protein

Top relations

Gene ontology · 18
Eosinophil cationic protein → antimicrobial humoral immune response mediated by antimicrobial peptide, antimicrobial humoral response, azurophil granule lumen, defense response to bacterium, endonuclease activity, extracellular region, extracellular space, hydrolase activity, innate immune response, innate immune response in mucosa, lipopolysaccharide binding, neutrophil degranulation, nuclease activity, nucleic acid binding, nucleic acid phosphodiester bond hydrolysis, ribonuclease activity, RNA catabolic process, RNA phosphodiester bond hydrolysis
Bgee · 10
Eosinophil cationic protein → blood, bone marrow, bone marrow cell, gonad, granulocyte, monocyte, mononuclear cell, spleen, testicle, trabecular bone
RNA expression pattern · 10
Eosinophil cationic protein → blood, bone marrow, bone marrow cell, gonad, granulocyte, monocyte, mononuclear cell, spleen, testicle, trabecular bone
related to Function · 4
Eosinophil cationic protein → Both, Eosinophil, Ribonuclease, RNASE2
Aliases · 1
Eosinophil cationic protein → RNASE3, ECP, RNS3, RAF1, ribonuclease A family member 3
Available structures · 1
Eosinophil cationic protein → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4A2O, 4X08, 1DYT, 4OXB, 2LVZ, 2KB5, 4OXF, 1QMT, 4OWZ, 1H1H, 4A2Y
Band · 1
Eosinophil cationic protein → 14q11.2
BioGPS · 1
Eosinophil cationic protein → n/a
Chr. · 1
Eosinophil cationic protein → Chromosome 14 (human)
Databases · 1
Eosinophil cationic protein → NCBI: entry; OMA: entry

Important terminology Word statistics

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Important terminology

ecp protein ribonuclease eosinophil activity also human apoptosis cells cationic eosinophils rnase3 asthma cell bp gene levels cytotoxicity chr chromosome

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Eosinophil cationic proteinAliasesRNASE3, ECP, RNS3, RAF1, ribonuclease A family member 31.00infobox
Eosinophil cationic proteinAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4A2O, 4X08, 1DYT, 4OXB, 2LVZ, 2KB5, 4OXF, 1QMT, 4OWZ, 1H1H, 4A2Y1.00infobox
Eosinophil cationic proteinBand14q11.21.00infobox
Eosinophil cationic proteinBgeetrabecular bone1.00infobox
Eosinophil cationic proteinBgeebone marrow1.00infobox
Eosinophil cationic proteinBgeebone marrow cell1.00infobox
Eosinophil cationic proteinBgeetesticle1.00infobox
Eosinophil cationic proteinBgeemononuclear cell1.00infobox
Eosinophil cationic proteinBgeemonocyte1.00infobox
Eosinophil cationic proteinBgeeblood1.00infobox
Eosinophil cationic proteinBgeegranulocyte1.00infobox
Eosinophil cationic proteinBgeespleen1.00infobox
Eosinophil cationic proteinBgeegonad1.00infobox
Eosinophil cationic proteinBioGPSn/a1.00infobox
Eosinophil cationic proteinChr.Chromosome 14 (human)1.00infobox
Eosinophil cationic proteinDatabasesNCBI: entry; OMA: entry1.00infobox
Eosinophil cationic proteinEnd20,892,348 bp1.00infobox
Eosinophil cationic proteinEnsemblENSG000001693971.00infobox
Eosinophil cationic proteinEntrez60371.00infobox
Eosinophil cationic proteinExternal IDsOMIM: 131398; MGI: 3528616; GeneCards: RNASE31.00infobox
Eosinophil cationic proteinGene location (Human)Gene location (Human)Chr.Chromosome 14 (human)Band14q11.2Start20,891,385 bpEnd20,892,348 bp1.00infobox
Eosinophil cationic proteinGene ontologynuclease activity1.00infobox
Eosinophil cationic proteinGene ontologyendonuclease activity1.00infobox
Eosinophil cationic proteinGene ontologyribonuclease activity1.00infobox
Eosinophil cationic proteinGene ontologyhydrolase activity1.00infobox
Eosinophil cationic proteinGene ontologynucleic acid binding1.00infobox
Eosinophil cationic proteinGene ontologylipopolysaccharide binding1.00infobox
Eosinophil cationic proteinGene ontologyextracellular region1.00infobox
Eosinophil cationic proteinGene ontologyextracellular space1.00infobox
Eosinophil cationic proteinGene ontologyazurophil granule lumen1.00infobox

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