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Protoxin-I

Protoxin-I, also known as ProTx-I, or Beta/omega-theraphotoxin-Tp1a, is a 35-amino-acid peptide neurotoxin extracted from the venom of the tarantula Thrixopelma pruriens. Protoxin-I belongs to the inhibitory cystine knot (ICK) family of peptide toxins, which have been known to potently inhibit voltage-gated ion channels. Protoxin-I selectively blocks low…

Applications, Structure and active site & Toxicodynamics

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Overview

Origin

Structure and active site

Toxicodynamics

Therapeutic uses

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Map overview Semantic statistics

Protoxin-I

Nodes37
Edges36
Triples63
Avg. degree1.95
Density0.054054
Components1

How this topic connects Entity context

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Protoxin-I

Top relations

related to Structure and active site · 29
Protoxin-I → As, By, Cys15-Cys28, Cys2-Cys16, Cys9-Cys21, D31A, F34A, G31A, Gating-modifier, Glu-Cys-Arg-Tyr-Trp-Leu-Gly-Gly-Cys-Ser-Ala-Gly-Gln-Thr-Cys-Cys-Lys-His-Leu-Val-Cys-Ser-Arg-Arg-His-Gly-Trp-Cys-Val-Trp-Asp-Gly-Thr-Phe-Ser, K17E, L19A, L6A, Lastly, NaV1, Nuclear Magnetic Resonance Spectroscopy, Q13A, R23A, R3A, S22A
related to Voltage-gated sodium channels · 9
Protoxin-I → ICK, II, IV, Nav1, Research, Similar, The, This, TTX-resistant
related to Origin · 7
Protoxin-I → Beta/omega-theraphotoxin-Bp1a, Bumba, It, Peruvian, The, Theraphosinae, Thrixopelma
related to Voltage-Gated T-type calcium channels · 6
Protoxin-I → CaV3, In, IV, S3-S4, T-type, Through
related to Therapeutic uses · 5
Protoxin-I → In, Modifications, NaV1, This, TRPA1
related to Transient receptor potential ankyrin 1 (TRPA1) · 5
Protoxin-I → NaV1, Protoxin, S1-S4, These, TRPA1
related to Toxicodynamics · 2
Protoxin-I → After, Like

Important terminology Word statistics

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Important terminology

channels trpa1 sodium voltage binding channel peptide nav1 voltage-gated t-type calcium residues domain toxins ion bind spider also potently pain

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Protoxin-Irelated to OriginThrixopelma0.60section
Protoxin-Irelated to OriginPeruvian0.60section
Protoxin-Irelated to OriginIt0.60section
Protoxin-Irelated to OriginThe0.60section
Protoxin-Irelated to OriginBeta/omega-theraphotoxin-Bp1a0.60section
Protoxin-Irelated to OriginBumba0.60section
Protoxin-Irelated to OriginTheraphosinae0.60section
Protoxin-Irelated to Structure and active siteGlu-Cys-Arg-Tyr-Trp-Leu-Gly-Gly-Cys-Ser-Ala-Gly-Gln-Thr-Cys-Cys-Lys-His-Leu-Val-Cys-Ser-Arg-Arg-His-Gly-Trp-Cys-Val-Trp-Asp-Gly-Thr-Phe-Ser0.60section
Protoxin-Irelated to Structure and active siteTable0.60section
Protoxin-Irelated to Structure and active siteCys2-Cys160.60section
Protoxin-Irelated to Structure and active siteCys9-Cys210.60section
Protoxin-Irelated to Structure and active siteCys15-Cys280.60section

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    Min side: 3
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