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Protamine

Protamines are small, arginine-rich, nuclear proteins that replace histones late in the haploid phase of spermatogenesis and are believed essential for sperm head condensation via genomic DNA compaction and stabilization. They may allow for denser packaging of DNA in the spermatozoon than histones, but they must be decompressed before the genetic data…

Applications, Species distribution and isoforms & Medical uses

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Species distribution and isoforms

PRM1PRM2TNP2Gene clusterEutherian
11 related topics

Medical uses

InsulinNPH insulinHeparinProtamine sulfateAntigenicity
10 related topics

Spermatogenesis

ToroidTransition nuclear proteinsMus
3 related topics

Structure

Disulfide bondsDityrosineGlycosaminoglycans
3 related topics

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Domains
InterPro
HGNC
9447
Locus
Chr. 16 p13.13
NCBI gene
5619
OMIM
182880
RefSeq
NM_002761

Topics to explore

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Overview

Spermatogenesis

Medical uses

Species distribution and isoforms

Structure

Advanced semantic analysis

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Map overview Semantic statistics

Protamine

Nodes43
Edges42
Triples56
Avg. degree1.95
Density0.046512
Components1

How this topic connects Entity context

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Protamine

Top relations

related to Spermatogenesis · 11
Protamine → Before, DNA, During, However, Human, In, Mus, N-terminal, O-shaped, Prm1/Prm2, The
related to Mammals · 8
Protamine → Eutherian, In, Metatherians, P1, PRM1, PRM2, The, TNP2
related to Structure · 8
Protamine → After, Another, By, DNA, P1, The, These, When
related to External links · 6
Protamine → Medicine Medical Subject Headings, MeSH, National Library, Protamines, V03AB14, WHO
related to Sequence · 4
Protamine → DNA, P1, The, This
related to Medical uses · 3
Protamine → Adverse, NPH, When
related to Species distribution and isoforms · 3
Protamine → In, Mice, PRM2
related to Fish · 2
Protamine → Examples, Fish
Domains · 1
Protamine → InterPro
HGNC · 1
Protamine → 9447

Important terminology Word statistics

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Important terminology

dna sperm proteins structure protamines histones prm2 humans prm1 nuclear head may pl fish gene p1 arginine-rich used domain mammals

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
ProtamineDomainsInterPro1.00infobox
ProtamineHGNC94471.00infobox
ProtamineLocusChr. 16 p13.131.00infobox
ProtamineNCBI gene56191.00infobox
ProtamineOMIM1828801.00infobox
ProtamineRefSeqNM_0027611.00infobox
ProtamineSearch forSearch forStructuresSwiss-modelDomainsInterPro1.00infobox
ProtamineStructuresSwiss-model1.00infobox
ProtamineSymbolPRM11.00infobox
ProtamineUniProtP045531.00infobox
Protamineused forpackaging DNA in sperm cells0.80text
Protaminerelated to External linksProtamines0.60section

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    Min side: 3
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