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Polygenic score

In genetics, a polygenic score (PGS) is a number that summarizes the estimated effect of many genetic variants on an individual's phenotype. The PGS is also called the polygenic index (PGI) or genome-wide score; in the context of disease risk, it is called a polygenic risk score (PRS or PR score) or genetic risk score. The score reflects an individual's…

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Overview

Background

Calculation with genome-wide association study

Application to humans

Applications in non-human species

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Polygenic score

Nodes60
Edges59
Triples99
Avg. degree1.97
Density0.033333
Components1

How this topic connects Entity context

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Polygenic score

Top relations

has application · 18
Polygenic score → Additionally, Although, Because, Conceptually, Despite, EBV, For, GEBV, GEBVs, In, Mendelian, PGS, Polygenic, PRS, SNP-based, SNPs, The, While
related to Benefits in humans · 17
Polygenic score → Celiac, Diabetes, DNA, Familial Hypercholesterolemia, For, Likewise, Moreover, Polygenic, Population, Recognizing, Several, The, This, Thus, Type, Unlike, While
related to Clinical utility and current usage · 14
Polygenic score → Alzheimer's, As, Color Genomics, Consumers, Impute, It, January, Most, Polygenic, PRS, Scripps Health, Since, The, This
related to Predictive performance in humans · 12
Polygenic score → African, Although, BMI, Chinese, European, Europeans, For, GWAS, However, Other, Significant, The
related to background · 10
Polygenic score → Although, DNA, Genome-wide, GWASes, Human DNA, Improvements, Learning, Similar, SNPs, The
related to Calculation with genome-wide association study · 6
Polygenic score → GWAS, In, PRS, SNP, SNPs, The
related to Key considerations · 5
Polygenic score → Methods, SNP, SNPs, The, Two
related to Application to humans · 4
Polygenic score → As, For, However, It
related to External links · 3
Polygenic score → Catalog, PGS, Polygenic Risk ScoresPolygenic Score

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Important terminology

polygenic genetic scores risk score disease prediction clinical trait humans association individuals snps prs variants use may diseases many used

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
learning algorithms for genomic predictioninstance ofThey are an active area of research spanning topics0.80text
poorer predictive performance in individuals of non-European ancestry limit widespread useinstance ofThe clinical utility may therefore still be large even if average measures of prediction performance are moderate.Although issues0.80text
several authors have noted that some causal variants for some conditionsinstance ofThe clinical utility may therefore still be large even if average measures of prediction performance are moderate.Although issues0.80text
but not othersinstance ofThe clinical utility may therefore still be large even if average measures of prediction performance are moderate.Although issues0.80text
are shared between Europeansinstance ofThe clinical utility may therefore still be large even if average measures of prediction performance are moderate.Although issues0.80text
other groups across different continents forinstance ofThe clinical utility may therefore still be large even if average measures of prediction performance are moderate.Although issues0.80text
ageinstance ofincluding additional information0.80text
sex often greatly improves the predictionsinstance ofincluding additional information0.80text
heightinstance ofas a means to assess group differences in a trait0.80text
or to examine changes in a trait over time due to natural selection indicative of a soft selective sweepinstance ofas a means to assess group differences in a trait0.80text
Polygenic scorehas applicationIn0.60section
Polygenic scorehas applicationAdditionally0.60section

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